scholarly journals Acute Autonomic, Sensory and Motor Neuropathy Associated with Meningoencephalitis

2009 ◽  
Vol 2 ◽  
pp. CCRep.S2194 ◽  
Author(s):  
Satoko Kinoshita ◽  
Kazuma Sugie ◽  
Hiroshi Kataoka ◽  
Miho Sugie ◽  
Makito Hirano ◽  
...  
Keyword(s):  
Medial Temporal Lobe ◽  
Sensory Neuropathy ◽  
Immunoglobulin Therapy ◽  
Magnetic Resonance Images ◽  
Motor Neuropathy ◽  
Neck Stiffness ◽  
Intravenous Immunoglobulin Therapy ◽  
Fluid Analysis ◽  
First Case ◽  
Immunological Therapy

We report the first case of acute autonomic, motor and sensory neuropathy (AASMN) associated with meningoencephalitis. A 62-year-old man presented with fever, neck stiffness, and coma. Respiratory failure developed. Magnetic resonance images showed an abnormality in the medial temporal lobe. Cerebrospinal fluid analysis revealed pleocytosis with a high protein level. Intensive care gradually improved the consciousness level, but paralysis of the four extremities persisted. Nerve conduction studies revealed demyelinating sensory and motor polyneuropathy. Severe orthostatic hypotension, urinary retention, and constipation were also present. Clinical autonomic tests suggested both sympathetic and parasympathetic dysfunction. After intravenous immunoglobulin therapy, motor and sensory symptoms resolved rapidly; dysautonomia resolved gradually over the next 2 months. The response to immunological therapy and the presence of antecedent infection suggest that AASMN is a postinfectious, immune-mediated, autonomic, sensory and motor nervous system dysfunction.

Meningitis and Hepatitis Complicating Intravenous Immunoglobulin Therapy

1996 ◽  
Vol 30 (10) ◽  
pp. 1115-1116 ◽  
Author(s):  
Andrew F. Shorr ◽  
Kent E. Kester
Keyword(s):  
African American Woman ◽  
American Woman ◽  
Ivig Therapy ◽  
Immunoglobulin Therapy ◽  
Intravenous Immunoglobulin Therapy ◽  
Autoimmune Syndrome ◽  
First Case ◽  
Acute Meningitis ◽  
Direct Toxicity ◽  
Infectious Etiology

OBJECTIVE: To report a case of concomitant meningitis and hepatitis complicating the use of intravenous immune globulin (IVIG). CASE SUMMARY: A 39-year-old African-American woman with an autoimmune syndrome developed both acute meningitis and hepatitis following administration of IVIG. These resolved over several days and left no sequellae. DISCUSSION: This represents the first case of concomitant acute meningitis and hepatitis associated with IVIG. Thorough microbiologic and serologic evaluation of the patient failed to demonstrate an infectious etiology. We postulate that our patient's syndrome resulted from direct toxicity of IVIG. CONCLUSIONS: Both acute meningitis and hepatitis may simultaneously complicate IVIG therapy. The specific mechanism remains unclear.

scholarly journals Intravenous immunoglobulin therapy in multifocal motor neuropathy: A double-blind, placebo-controlled study

Brain ◽  
2001 ◽  
Vol 124 (1) ◽  
pp. 145-153 ◽  
Author(s):  
J.-M. Leger ◽  
B. Chassande ◽  
L. Musset ◽  
V. Meininger ◽  
P. Bouche ◽  
...  
Keyword(s):  
Intravenous Immunoglobulin ◽  
Immunoglobulin Therapy ◽  
Multifocal Motor Neuropathy ◽  
Controlled Study ◽  
Motor Neuropathy ◽  
Double Blind ◽  
Intravenous Immunoglobulin Therapy ◽  
Double Blind Placebo

Varicella zoster meningitis in a pregnant woman with uncontrolled type 1 diabetes mellitus

2021 ◽  
Vol 14 (2) ◽  
pp. e236644
Author(s):  
Laura Mroue ◽  
Harpreet Brar ◽  
Bernard Gonik
Keyword(s):  
Medical Literature ◽  
Pregnant Patient ◽  
Cerebrospinal Fluid Analysis ◽  
Neck Stiffness ◽  
Varicella Zoster ◽  
Fluid Analysis ◽  
First Case ◽  
The Us ◽  
History Of

We report the case of retrograde varicella zoster virus (VZV) reactivation presenting as aseptic meningitis without rash in a generally healthy pregnant patient. A 27-year-old nulliparous woman at 25 weeks of gestation presented to the emergency department with a 1-day history of severe headache associated with nausea, photophobia and neck stiffness. After ruling out a space-occupying lesion by brain imaging, lumbar puncture was performed. Cerebrospinal fluid analysis by PCR revealed the presence of VZV, making the diagnosis of acute varicella meningitis. The patient had immunoglobulin studies consistent with a history of primary VZV infection, thus confirming reactivation of VZV rather than primary infection. The patient was treated with acyclovir for 14 days and recovered fully. Her neonate was delivered full term without any evidence of vertical transmission. This is only the second reported case of VZV meningitis in a pregnant patient in the medical literature, and the first case in the US that was reported.

Multiphasic acute disseminated encephalomyelitis associated with atypical rubella virus infection

2014 ◽  
Vol 21 (2) ◽  
pp. 252-254 ◽  
Author(s):  
Koji Shinoda ◽  
Hideaki Asahara ◽  
Taira Uehara ◽  
Katsue Miyoshi ◽  
Satoshi O Suzuki ◽  
...  
Keyword(s):  
Virus Infection ◽  
Rubella Virus ◽  
Immunoglobulin Therapy ◽  
Acute Disseminated Encephalomyelitis ◽  
Pulse Therapy ◽  
Unknown Etiology ◽  
Intravenous Immunoglobulin Therapy ◽  
First Case ◽  
History Of ◽  
Rubella Virus Infection

We report the first case of an occurrence of multiphasic acute disseminated encephalomyelitis (ADEM) associated with atypical rubella virus infection with no rash and long-term increased titers of serum anti-rubella IgM in a 17-year-old male who had no history of rubella vaccination. He suffered from at least six clinical exacerbations with disseminated hyperintense lesions on FLAIR MR images during the course of 18 months. Repeated methylprednisolone pulse therapy and intravenous immunoglobulin therapy resolved the exacerbations. In patients with multiphasic ADEM of unknown etiology, clinicians should also consider the possibility of preceding infection with rubella virus.

scholarly journals High-dose intravenous immunoglobulin therapy in multifocal motor neuropathy

Neurology ◽  
1993 ◽  
Vol 43 (3, Part 1) ◽  
pp. 537-537 ◽  
Author(s):  
E. Nobile-Orazio ◽  
N. Meucci ◽  
S. Barbieri ◽  
M. Carpo ◽  
G. Scarlato
Keyword(s):  
Intravenous Immunoglobulin ◽  
Immunoglobulin Therapy ◽  
Multifocal Motor Neuropathy ◽  
High Dose ◽  
Motor Neuropathy ◽  
Intravenous Immunoglobulin Therapy

scholarly journals How We Treat Autoimmune Small Fiber Polyneuropathy with Immunoglobulin Therapy

2018 ◽  
Vol 80 (5-6) ◽  
pp. 304-310 ◽  
Author(s):  
Jill R. Schofield ◽  
Kamal R. Chemali
Keyword(s):  
Intravenous Immunoglobulin ◽  
Chronic Inflammatory Demyelinating Polyneuropathy ◽  
Immunoglobulin Therapy ◽  
Multifocal Motor Neuropathy ◽  
Motor Neuropathy ◽  
Intravenous Immunoglobulin Therapy ◽  
Small Fiber ◽  
Immune Mediated ◽  
Inflammatory Demyelinating Polyneuropathy ◽  
Significant Efficacy

Intravenous immunoglobulin therapy is FDA approved for the immune-mediated peripheral nerve disorders Guillain-Barre syndrome, chronic inflammatory demyelinating polyneuropathy, and multifocal motor neuropathy. Immunoglobulin therapy has been used increasingly with significant efficacy in the treatment of patients with disabling autoimmune forms of dysautonomia, which are most often small fiber (autonomic and/or sensory) polyneuropathies. It is recognized by most who treat these disorders, however, that patients with autonomic dysfunction treated with intravenous immunoglobulin therapy develop aseptic meningitis or severe lingering headache more frequently than other patient populations when this therapy is dosed in the traditional fashion. We discuss our combined 27 years of experience with the use of immunoglobulin and other immune modulatory therapy in patients with autoimmune small fiber polyneuropathy.

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