Role of Tumor Suppressor Protein p53 in Apoptosis and Cancer Therapy

2011 ◽  
Vol 03 (06) ◽  
Author(s):  
Naga Deepthi CH ◽  
VVL Pavan Kumar ◽  
Ramesh babu ◽  
U Indirapriya darshini
Keyword(s):  
Cancer Therapy ◽  
Tumor Suppressor ◽  
Tumor Suppressor Protein ◽  
Tumor Suppressor Protein P53 ◽  
Protein P53

scholarly journals Distinct modulatory role of RNA in the aggregation of the tumor suppressor protein p53 core domain

2017 ◽  
Vol 292 (22) ◽  
pp. 9345-9357 ◽  
Author(s):  
Petar Stefanov Kovachev ◽  
Debapriya Banerjee ◽  
Luciana Pereira Rangel ◽  
Jonny Eriksson ◽  
Murilo M. Pedrote ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Tumor Suppressor Protein ◽  
Core Domain ◽  
Tumor Suppressor Protein P53 ◽  
Protein P53

scholarly journals Rewired Notch/p53 by Numb’ing Mdm2

2018 ◽  
Vol 217 (2) ◽  
pp. 445-446 ◽  
Author(s):  
Hyungsoo Kim ◽  
Ze’ev A. Ronai
Keyword(s):  
Breast Cancer ◽  
Tumor Suppressor ◽  
Therapeutic Intervention ◽  
Splice Variant ◽  
Tumor Suppressor Protein ◽  
Tumor Suppressor Protein P53 ◽  
Protein P53 ◽  
Cell Biol ◽  
Coordinated Regulation

Although numerous pathways are known to control the tumor suppressor protein p53, coordinated regulation of the p53–Notch axis by Numb may have an even more remarkable impact. In this issue, Colaluca at al. (2018. J. Cell Biol. https://doi.org/10.1083/jcb.201709092) reveal an unexpected role of a newly characterized Numb splice variant in the regulation of p53, which may have significant implications for therapeutic intervention in breast cancer.

Human Metalloproteinase-1 (Collagenase-1) Is a Tumor Suppressor Protein p53 Target Gene

1999 ◽  
Vol 878 (1 INHIBITION OF) ◽  
pp. 638-641 ◽  
Author(s):  
YUBO SUN ◽  
YI SUN ◽  
LEONOR WENGER ◽  
JONI L. RUTTER ◽  
CONSTANCE E. BRINCKERHOFF ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Target Gene ◽  
Tumor Suppressor Protein ◽  
Tumor Suppressor Protein P53 ◽  
Protein P53 ◽  
P53 Target Gene
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