scholarly journals Mitral Annulus Calcification and Cardiac Conduction Disturbances: a DANCAVAS Sub-study

2022 ◽  
Vol 30 ◽  
Author(s):  
Jeppe Holm Rasmussen ◽  
Maise Hoeigaard Fredgart ◽  
Jes Sanddal Lindholt ◽  
Jens Brock Johansen ◽  
Niels Sandgaard ◽  
...  
Keyword(s):  
Mitral Annulus ◽  
Cardiac Conduction ◽  
Conduction Disturbances ◽  
Mitral Annulus Calcification

scholarly journals Correction to: Transcatheter Mitral Valve Implantation Systematic Review: Focuson Transseptal Approach and Mitral Annulus Calcification

2021 ◽  
Vol 23 (4) ◽  
Author(s):  
W. Ben-Ali ◽  
R. Ibrahim ◽  
J. Rodès-Cabeau ◽  
R. S. von Bardeleben ◽  
D. Mylotte ◽  
...  
Keyword(s):  
Systematic Review ◽  
Mitral Valve ◽  
Mitral Annulus ◽  
Mitral Annulus Calcification ◽  
Transseptal Approach ◽  
Valve Implantation

Mitral Annulus Calcification: Is It Benign?

1992 ◽  
Vol 40 (4) ◽  
pp. 427-427
Author(s):  
Moshe Algom ◽  
Zalman Zilber ◽  
Beni Habot ◽  
Jack Madjar ◽  
Zwi Schlesinger
Keyword(s):  
Mitral Annulus ◽  
Mitral Annulus Calcification

scholarly journals Regulation of Cardiac Conduction and Arrhythmias by Ankyrin/Spectrin-Based Macromolecular Complexes

2021 ◽  
Vol 8 (5) ◽  
pp. 48
Author(s):  
Drew Nassal ◽  
Jane Yu ◽  
Dennison Min ◽  
Cemantha Lane ◽  
Rebecca Shaheen ◽  
...  
Keyword(s):  
Ion Channels ◽  
Cardiac Disease ◽  
Conduction System ◽  
Cytoskeletal Proteins ◽  
Cardiac Conduction ◽  
Proper Function ◽  
Cardiac Conduction System ◽  
Loss Of Function ◽  
Macromolecular Complexes ◽  
Conduction Disturbances

The cardiac conduction system is an extended network of excitable tissue tasked with generation and propagation of electrical impulses to signal coordinated contraction of the heart. The fidelity of this system depends on the proper spatio-temporal regulation of ion channels in myocytes throughout the conduction system. Importantly, inherited or acquired defects in a wide class of ion channels has been linked to dysfunction at various stages of the conduction system resulting in life-threatening cardiac arrhythmia. There is growing appreciation of the role that adapter and cytoskeletal proteins play in organizing ion channel macromolecular complexes critical for proper function of the cardiac conduction system. In particular, members of the ankyrin and spectrin families have emerged as important nodes for normal expression and regulation of ion channels in myocytes throughout the conduction system. Human variants impacting ankyrin/spectrin function give rise to a broad constellation of cardiac arrhythmias. Furthermore, chronic neurohumoral and biomechanical stress promotes ankyrin/spectrin loss of function that likely contributes to conduction disturbances in the setting of acquired cardiac disease. Collectively, this review seeks to bring attention to the significance of these cytoskeletal players and emphasize the potential therapeutic role they represent in a myriad of cardiac disease states.

scholarly journals Liquefaction Necrosis of Mitral Annulus Calcification

Circulation ◽  
2008 ◽  
Vol 117 (12) ◽  
Author(s):  
Gianluca Di Bella ◽  
Pier Giorgi Masci ◽  
Javier Ganame ◽  
Steven Dymarkowski ◽  
Jan Bogaert
Keyword(s):  
Mitral Annulus ◽  
Mitral Annulus Calcification

scholarly journals Massive Myocardial Calcification—A Heart Of Stone!

2021 ◽  
Author(s):  
Mariana Tinoco ◽  
Pedro Von Hafe ◽  
Sérgio Leite ◽  
Margarida Oliveira ◽  
Olga Azevedo ◽  
...  
Keyword(s):  
Troponin I ◽  
Nyha Class ◽  
Mitral Annulus ◽  
Left Ventricular ◽  
Oral Rehydration ◽  
Myocardial Calcification ◽  
Septal Thickness ◽  
Mitral Annulus Calcification ◽  
History Of ◽  
History Of Obesity

Abstract A 71-year-old female was admitted in the emergency room after effort-related syncope. She had past medical history of obesity and hypertension treated with lercanidipine. No relevant family history. Physical examination revealed systolic murmur (grade 2/6). ECG showed sinus rhythm and left bundle brunch block (Supplementary figure). Lab results were unremarkable including troponin I. Transthoracic echocardiography (TTE) revealed moderate left ventricular (LV) hypertrophy [septal thickness 14 mm (normal: 6–9mm)], extensive mitral annulus calcification (MAC) with exuberant myocardial calcification at the level of posterior leaflet that invaded adjacent LV walls, systolic anterior motion of the anterior mitral leaflet causing LV outflow tract (LVOT) obstruction (maximum gradient 34 mmHg) and moderate mitral regurgitation (MR) (Panel A). Exercise echocardiogram provoked LVOT gradient >100mmHg and severe MR. Continuous ECG monitoring during 13 days demonstrated no arrhythmic events. Cardiac CT showed multiple calcifications extending from mitral annulus to LV anterior and lateral walls and cardiac MRI was compatible with caseous MAC (Panels B-F). Coronary angiography showed 50% stenosis of mid left anterior descending artery. Normal thoracic CT and ACE, and negative IGRA excluded sarcoidosis and tuberculosis. Comprehensive study, including calcium metabolism and autoantibodies, excluded metabolic and inflammatory aetiologies of myocardial calcification, which was assumed as dystrophic in the context of MAC. No syncope occurred after bisoprolol 2.5 mg, oral rehydration and discontinuation of lercanidipine. However, rest and exercise TTE failed to show improvement of LVOT gradient or MR and patient remained on NYHA class II-III, despite maximal tolerated dose of bisoprolol (5 mg), being therefore referred to cardiac surgery.

Successful surgical treatment for total circumferential aortic and mitral annulus calcification: application of half-and-half technique

2014 ◽  
Vol 64 (7) ◽  
pp. 418-421 ◽  
Author(s):  
Yosuke Takahashi ◽  
Yasuyuki Sasaki ◽  
Koji Hattori ◽  
Yasuyuki Kato ◽  
Manabu Motoki ◽  
...  
Keyword(s):  
Surgical Treatment ◽  
Mitral Annulus ◽  
Mitral Annulus Calcification

MITRAL ANNULUS CALCIFICATION AND CEREBRAL ISCHÆMIA

The Lancet ◽  
1979 ◽  
Vol 314 (8147) ◽  
pp. 860 ◽  
Author(s):  
T.A. Traill ◽  
N.J. Fortuin
Keyword(s):  
Cerebral Ischaemia ◽  
Mitral Annulus ◽  
Mitral Annulus Calcification

scholarly journals 4107Results of Transcatheter Mitral Valve Implantation in Patients with Bioprosthesis Or Annuloplasty Failure Or Mitral Annulus Calcification

2017 ◽  
Vol 38 (suppl_1) ◽  
Author(s):  
M. Urena ◽  
D. Himbert ◽  
E. Brochet ◽  
M. Lecomte ◽  
J.L. Carrasco ◽  
...  
Keyword(s):  
Mitral Valve ◽  
Mitral Annulus ◽  
Mitral Annulus Calcification ◽  
Valve Implantation
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