scholarly journals Association of single nucleotide polymorphisms in genes coding insulin-like growth factor 1 system and milk production traits in Montbeliarde cows

2016 ◽  
Vol 46 (2) ◽  
pp. 191
Author(s):  
M Szewczuk
Keyword(s):  
Growth Factor ◽  
Single Nucleotide Polymorphisms ◽  
Milk Production ◽  
Insulin Like Growth Factor ◽  
Nucleotide Polymorphisms ◽  
Production Traits ◽  
Milk Production Traits ◽  
Single Nucleotide

Association between single nucleotide polymorphisms (SNPs) and milk production traits in Italian Brown cattle

2013 ◽  
Vol 157 (1) ◽  
pp. 93-99 ◽  
Author(s):  
G. Mancini ◽  
E.L. Nicolazzi ◽  
A. Valentini ◽  
G. Chillemi ◽  
P. Ajmone Marsan ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Milk Production ◽  
Nucleotide Polymorphisms ◽  
Production Traits ◽  
Milk Production Traits ◽  
Single Nucleotide ◽  
Brown Cattle

Single nucleotide polymorphisms in bovine PRL gene and their associations with milk production traits in Chinese Holsteins

2009 ◽  
Vol 37 (1) ◽  
pp. 547-551 ◽  
Author(s):  
Aijun Lü ◽  
Xiucai Hu ◽  
Hong Chen ◽  
Jihong Jiang ◽  
Chunlei Zhang ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Milk Production ◽  
Nucleotide Polymorphisms ◽  
Production Traits ◽  
Milk Production Traits ◽  
Single Nucleotide ◽  
Prl Gene

Association of polymorphisms in exons 2 and 10 of the insulin-like growth factor 2 (IGF2) gene with milk production traits in Polish Holstein-Friesian cattle

2009 ◽  
Vol 77 (1) ◽  
pp. 37-42 ◽  
Author(s):  
Emilia Bagnicka ◽  
Eulalia Siadkowska ◽  
Nina Strzałkowska ◽  
Beata Żelazowska ◽  
Krzysztof Flisikowski ◽  
...  
Keyword(s):  
Growth Factor ◽  
Milk Production ◽  
Insulin Like Growth Factor ◽  
Nucleotide Polymorphisms ◽  
Production Traits ◽  
Milk Production Traits ◽  
Milk Traits ◽  
Exon 2 ◽  
Holstein Friesian ◽  
Exon 10

Insulin-like growth factor 2 (IGF2) is considered to be a regulator of post-natal growth and differentiation of the mammary gland. In the present work, associations of two single nucleotide polymorphisms in the bovine IGF2 gene with milk production traits were studied in dairy Holstein-Friesian cows: the already described g.8656C>T transition in exon 2 (RFLP-BsrI) and the newly found g.24507G>T transversion in exon 10 (RFLP-HaeIII), found by sequencing 273-bp exon 10 of the IGF2 gene in six individuals. Associations were analysed individually and in combination with the multi-trait repeatability test-day animal model. The CT/GT haplotype appeared to be associated with most of the milk traits studied (differences were significant at P⩽0·001). The most frequent CT/GG haplotype seemed inferior to others in fat and protein content and daily yield of fat and protein but superior (together with the TT/GG genotype) when the daily milk yield is considered.

scholarly journals Association between single-nucleotide polymorphisms and milk production traits in buffalo

2014 ◽  
Vol 13 (4) ◽  
pp. 10256-10268 ◽  
Author(s):  
G.C. Venturini ◽  
D.F. Cardoso ◽  
F. Baldi ◽  
A.C. Freitas ◽  
R.R. Aspilcueta-Borquis ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Milk Production ◽  
Nucleotide Polymorphisms ◽  
Production Traits ◽  
Milk Production Traits ◽  
Single Nucleotide

scholarly journals Validation of single nucleotide polymorphisms associated with milk production traits in dairy cattle

2012 ◽  
Vol 95 (2) ◽  
pp. 864-875 ◽  
Author(s):  
A.J. Chamberlain ◽  
B.J. Hayes ◽  
K. Savin ◽  
S. Bolormaa ◽  
H.C. McPartlan ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Dairy Cattle ◽  
Milk Production ◽  
Nucleotide Polymorphisms ◽  
Production Traits ◽  
Milk Production Traits ◽  
Single Nucleotide

scholarly journals Identification of single nucleotide polymorphisms of PIK3R1 and DUSP1 genes and their genetic associations with milk production traits in dairy cows

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Bo Han ◽  
Yuwei Yuan ◽  
Lijun Shi ◽  
Yanhua Li ◽  
Lin Liu ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Dairy Cows ◽  
Milk Production ◽  
Nucleotide Polymorphisms ◽  
Production Traits ◽  
Genetic Associations ◽  
Milk Production Traits ◽  
Single Nucleotide ◽  
Association Analyses ◽  
Flanking Region

Abstract Background Previously, phosphoinositide-3-kinase regulatory subunit 1 (PIK3R1) and dual specificity phosphatase 1 (DUSP1) were identified as promising candidate genes for milk production traits due to their being differentially expressed between the dry period and the peak of lactation in livers of dairy cows. Hence, in this study, the single nucleotide polymorphisms (SNPs) of PIK3R1 and DUSP1 genes were identified and their genetic associations with milk yield, fat yield, fat percentage, protein yield, and protein percentage, were investigated using 1067 Chinese Holstein cows from 40 sire families. Results By re-sequencing the entire coding region and 2000 bp of the 5′ and 3′ flanking regions of the two genes, one SNP in the 5′ untranslated region (UTR), three in the 3′ UTR, and two in the 3′ flanking region of PIK3R1 were identified, and one in the 5′ flanking region, one in the 3′ UTR, and two in the 3′ flanking region of DUSP1 were found. Subsequent single-locus association analyses showed that five SNPs in PIK3R1, rs42590258, rs210389799, rs208819656, rs41255622, rs133655926, and rs211408208, and four SNPs in DUSP1, rs207593520, rs208460068, rs209154772, and rs210000760, were significantly associated with milk, fat and protein yields in the first or second lactation (P values ≤ 0.0001 and 0.0461). In addition, by the Haploview 4.2 software, the six and four SNPs in PIK3R1 and DUSP1 respectively formed one haplotype block, and the haplotype-based association analyses showed significant associations between their haplotype combinations and the milk traits in both two lactations (P values ≤ 0.0001 and 0.0364). One SNP, rs207593520(T/G), was predicted to alter the transcription factor binding sites (TFBSs) in the 5′ flanking region of DUSP1. Further, the dual-luciferase assay showed that the transcription activity of allele T in rs207593520 was significantly higher than that of allele G, suggesting the activation of transcriptional activity of DUSP1 gene by allele T of rs207593520. Thus, the rs207593520 SNP was highlighted as a potential causal mutation that should be further verified. Conclusions We demonstrated novel and significant genetic effects of the PIK3R1 and DUSP1 genes on milk production traits in dairy cows, and our findings provide information for use in dairy cattle breeding.

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