Single nucleotide polymorphisms in bovine PRL gene and their associations with milk production traits in Chinese Holsteins

2009 ◽  
Vol 37 (1) ◽  
pp. 547-551 ◽  
Author(s):  
Aijun Lü ◽  
Xiucai Hu ◽  
Hong Chen ◽  
Jihong Jiang ◽  
Chunlei Zhang ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Milk Production ◽  
Nucleotide Polymorphisms ◽  
Production Traits ◽  
Milk Production Traits ◽  
Single Nucleotide ◽  
Prl Gene

Association between single nucleotide polymorphisms (SNPs) and milk production traits in Italian Brown cattle

2013 ◽  
Vol 157 (1) ◽  
pp. 93-99 ◽  
Author(s):  
G. Mancini ◽  
E.L. Nicolazzi ◽  
A. Valentini ◽  
G. Chillemi ◽  
P. Ajmone Marsan ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Milk Production ◽  
Nucleotide Polymorphisms ◽  
Production Traits ◽  
Milk Production Traits ◽  
Single Nucleotide ◽  
Brown Cattle

scholarly journals Association between single-nucleotide polymorphisms and milk production traits in buffalo

2014 ◽  
Vol 13 (4) ◽  
pp. 10256-10268 ◽  
Author(s):  
G.C. Venturini ◽  
D.F. Cardoso ◽  
F. Baldi ◽  
A.C. Freitas ◽  
R.R. Aspilcueta-Borquis ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Milk Production ◽  
Nucleotide Polymorphisms ◽  
Production Traits ◽  
Milk Production Traits ◽  
Single Nucleotide

scholarly journals Validation of single nucleotide polymorphisms associated with milk production traits in dairy cattle

2012 ◽  
Vol 95 (2) ◽  
pp. 864-875 ◽  
Author(s):  
A.J. Chamberlain ◽  
B.J. Hayes ◽  
K. Savin ◽  
S. Bolormaa ◽  
H.C. McPartlan ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Dairy Cattle ◽  
Milk Production ◽  
Nucleotide Polymorphisms ◽  
Production Traits ◽  
Milk Production Traits ◽  
Single Nucleotide

scholarly journals Identification of single nucleotide polymorphisms of PIK3R1 and DUSP1 genes and their genetic associations with milk production traits in dairy cows

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Bo Han ◽  
Yuwei Yuan ◽  
Lijun Shi ◽  
Yanhua Li ◽  
Lin Liu ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Dairy Cows ◽  
Milk Production ◽  
Nucleotide Polymorphisms ◽  
Production Traits ◽  
Genetic Associations ◽  
Milk Production Traits ◽  
Single Nucleotide ◽  
Association Analyses ◽  
Flanking Region

Abstract Background Previously, phosphoinositide-3-kinase regulatory subunit 1 (PIK3R1) and dual specificity phosphatase 1 (DUSP1) were identified as promising candidate genes for milk production traits due to their being differentially expressed between the dry period and the peak of lactation in livers of dairy cows. Hence, in this study, the single nucleotide polymorphisms (SNPs) of PIK3R1 and DUSP1 genes were identified and their genetic associations with milk yield, fat yield, fat percentage, protein yield, and protein percentage, were investigated using 1067 Chinese Holstein cows from 40 sire families. Results By re-sequencing the entire coding region and 2000 bp of the 5′ and 3′ flanking regions of the two genes, one SNP in the 5′ untranslated region (UTR), three in the 3′ UTR, and two in the 3′ flanking region of PIK3R1 were identified, and one in the 5′ flanking region, one in the 3′ UTR, and two in the 3′ flanking region of DUSP1 were found. Subsequent single-locus association analyses showed that five SNPs in PIK3R1, rs42590258, rs210389799, rs208819656, rs41255622, rs133655926, and rs211408208, and four SNPs in DUSP1, rs207593520, rs208460068, rs209154772, and rs210000760, were significantly associated with milk, fat and protein yields in the first or second lactation (P values ≤ 0.0001 and 0.0461). In addition, by the Haploview 4.2 software, the six and four SNPs in PIK3R1 and DUSP1 respectively formed one haplotype block, and the haplotype-based association analyses showed significant associations between their haplotype combinations and the milk traits in both two lactations (P values ≤ 0.0001 and 0.0364). One SNP, rs207593520(T/G), was predicted to alter the transcription factor binding sites (TFBSs) in the 5′ flanking region of DUSP1. Further, the dual-luciferase assay showed that the transcription activity of allele T in rs207593520 was significantly higher than that of allele G, suggesting the activation of transcriptional activity of DUSP1 gene by allele T of rs207593520. Thus, the rs207593520 SNP was highlighted as a potential causal mutation that should be further verified. Conclusions We demonstrated novel and significant genetic effects of the PIK3R1 and DUSP1 genes on milk production traits in dairy cows, and our findings provide information for use in dairy cattle breeding.

Study on candidate genes for milk production traits of Red Chittagong Cattle

2020 ◽  
Vol 26 (1-2) ◽  
pp. 1-7
Author(s):  
MP Mostari ◽  
MYA Khan
Keyword(s):  
Candidate Genes ◽  
Milk Production ◽  
Milk Fat ◽  
Nucleotide Polymorphisms ◽  
Production Traits ◽  
Milk Production Traits ◽  
Single Nucleotide ◽  
Lactating Cows ◽  
Pooled Dna ◽  
Fat Yield

The study was carried out on Stearoyl-CoA desaturase (SCD,) diacylglycerolacyltransferase-1 (DGAT1) and ATP-binding cassette G2 (ABCG2) genes which are responsible for variation in milk production traits (milk yield, fat yield, protein yield, and SNF yield) in cattle. These genes were used as candidate genes in Red Chittagong Cattle (RCC) breed of Bangladesh Livestock Research Institute (BLRI) herd for detection of single nucleotide polymorphisms (SNPs) causing variation in milk production traits. Focusing on the effects of SNPs on milk production traits, phenotypic variation within RCC breed was identified and categorized based on milk production traits. Average lactation yield varied from 527 to 1436 kg (n=29) per lactation. About 18% of lactating cows showed an average of >1000 kg per lactation. Average fat percent ranged from 4.71 to 6.25 (n=15). Eighteen (18) set of primers were designed to amplify targeted regions of SCD, DGAT1 and ABCG2 genes, where 8 set from DGAT1, 6 set from SCD and 4 set from ABCG2 gene. Pooled DNA from 50 RCC cows and 5 RCC bulls were used in sequencing. In sequence analysis, the SCD, DGAT1 and ABCG2 alleles found fixed in RCC. This study suggests an evidence that RCC breed has fixed alleles with respect to SCD, DGAT1 and ABCG2 genes reported to be responsible for higher milk fat yield, higher fat and protein percent. Bang. J. Livs. Res. Vol. 26 (1&2), 2019: P. 1-7

Molecular characterisation of the buffalo SCAP gene and its association with milk production traits in water buffaloes

2018 ◽  
Vol 85 (2) ◽  
pp. 133-137
Author(s):  
Tingxian Deng ◽  
Xiaoya Ma ◽  
Chunying Pang ◽  
Shasha Liang ◽  
Xingrong Lu ◽  
...  
Keyword(s):  
Milk Production ◽  
Gene Expression Analysis ◽  
Open Reading Frame ◽  
Molecular Characterisation ◽  
Early Lactation ◽  
Nucleotide Polymorphisms ◽  
Production Traits ◽  
Milk Production Traits ◽  
Single Nucleotide ◽  
Reading Frame

The study reported in this Research Communication was conducted to investigate the molecular characterisation of buffalo SCAP gene, expression analysis, and the association between single nucleotide polymorphisms and milk production traits in 384 buffaloes. Sequence analysis revealed the SCAP gene had an open reading frame of 3837 bp encoding 1279 amino acids. A ubiquitous expression profile of SCAP gene was detected in various tissues with extreme predominance in the mammary gland during early lactation. Moreover, eleven SNPs in buffalo SCAP gene were identified, six of them (g.1717600A>G, g.1757922C>T, g.1758953G>A, g.1759142C>T, g.1760740G>A, and g.1766036T>C) were found to be significantly associated with 305-day milk yield. Thus, buffalo SCAP could sever as a candidate gene affecting milk production traits in buffalo and the identified SNPs might potentially be genetic markers.

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