scholarly journals Efficacy of low-concentration hypochlorous acid spray in acute sore throat relief

2018 ◽  
Vol 6 (3) ◽  
Author(s):  
Taylan Gun
Keyword(s):  
Sore Throat ◽  
Hypochlorous Acid ◽  
Low Concentration

Effects of a Low Concentration Hypochlorous Acid Nasal Irrigation Solution on Bacteria, Fungi, and Virus

2008 ◽  
Vol 118 (10) ◽  
pp. 1862-1867 ◽  
Author(s):  
Hyun Jik Kim ◽  
Jeung-Gweon Lee ◽  
Ju Wan Kang ◽  
Hyung-Ju Cho ◽  
Hyun Su Kim ◽  
...  
Keyword(s):  
Hypochlorous Acid ◽  
Low Concentration ◽  
Nasal Irrigation ◽  
Irrigation Solution

scholarly journals Allergic Potency of Japanese Cedar Pollen Cry j 1 Is Reduced by a Low Concentration of Hypochlorous Acid Generated by Electolysis

2009 ◽  
Vol 58 (2) ◽  
pp. 255-260 ◽  
Author(s):  
Tetsuya Terada ◽  
Yoko Akimoto ◽  
Sawako Hyo ◽  
Daisuke Suzuki ◽  
Kazuhiko Tanaka ◽  
...  
Keyword(s):  
Hypochlorous Acid ◽  
Japanese Cedar ◽  
Low Concentration ◽  
Japanese Cedar Pollen ◽  
Cedar Pollen

Improved outcomes after low-concentration hypochlorous acid nasal irrigation in pediatric chronic sinusitis

2015 ◽  
Vol 126 (4) ◽  
pp. 791-795 ◽  
Author(s):  
Hyung-Ju Cho ◽  
Hyun Jin Min ◽  
Hyo Jin Chung ◽  
Do-Yang Park ◽  
Sang Yeob Seong ◽  
...  
Keyword(s):  
Hypochlorous Acid ◽  
Chronic Sinusitis ◽  
Low Concentration ◽  
Nasal Irrigation ◽  
Improved Outcomes

scholarly journals Action of hypochlorous acid on the antioxidant protective enzymes superoxide dismutase, catalase and glutathione peroxidase

1987 ◽  
Vol 248 (3) ◽  
pp. 973-976 ◽  
Author(s):  
O I Aruoma ◽  
B Halliwell
Keyword(s):  
Superoxide Dismutase ◽  
Glutathione Peroxidase ◽  
Reperfusion Injury ◽  
Hypochlorous Acid ◽  
Low Concentration ◽  
Inflammatory Agent ◽  
Cuzn Superoxide Dismutase ◽  
Protective Enzymes ◽  
Anti Inflammatory

The neutrophil enzyme myeloperoxidase generates hypochlorous acid (HOCl) at sites of inflammation. Glutathione peroxidase is very quickly inactivated by low concentration of HOCl. Inactivation of catalase is also rapid, but requires higher HOCl concentrations and the haem appears to be degraded. Inactivation of bovine CuZn superoxide dismutase is slower. Hence superoxide dismutase should not be easily inactivated by HOCl at sites of inflammation, which may contribute to its effectiveness as an anti-inflammatory agent and in minimizing reperfusion injury.

Hypochlorous Acid Versus Saline Nasal Irrigation in Allergic Rhinitis: A Multicenter, Randomized, Double-Blind, Placebo-controlled Study

2021 ◽  
pp. 194589242110294
Author(s):  
Ho Chan Kim ◽  
Dong-Kyu Kim ◽  
Ji Sun Kim ◽  
Ho Jun Lee ◽  
Mi Rye Bae ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Hypochlorous Acid ◽  
Nasal Symptom ◽  
Controlled Study ◽  
Life Questionnaire ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Low Concentration ◽  
Nasal Irrigation ◽  
Before And After

Background Low concentrations of hypochlorous acid (HOCl) have proven antipruritic, anti-inflammatory, and antimicrobial effects without toxicity, although the mechanism has not been fully elucidated. Objective The aim of this study was to evaluate the effectiveness of HOCl nasal irrigation to reduce allergic rhinitis (AR) symptoms compared with saline nasal irrigation. Methods This was multicenter, randomized, double-blind, placebo-controlled study. Initially, 139 patients with perennial AR were enrolled; however, 25 did not successfully complete the study. Patients were randomly assigned to the nasal irrigation with low-concentration HOCl (n = 55) or normal saline (n = 59) treatment groups for the 4-week study period. Participants completed the Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ) at every visit (baseline, Weeks 2 and 4), and Total Nasal Symptom Score (TNSS) was determined before and after nasal irrigation every morning and evening. Results We found that RQLQ scores significantly decreased after 4 weeks in the HOCl and placebo groups, but the decrement of the RQLQ score was similar between the 2 groups. Additionally, TNSS improved in both groups between baseline and Week 4, whereas there were no significant differences in the change of TNSS between the 2 groups. The HOCl group did not show any clinical side effects related to nasal irrigation. Conclusion Allergic symptoms significantly decreased with low-concentration HOCl nasal irrigation, without significant adverse events. However, HOCl showed no additional improvement in symptoms compared with saline nasal irrigation for patients with perennial AR.

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