Hypochlorous Acid Versus Saline Nasal Irrigation in Allergic Rhinitis: A Multicenter, Randomized, Double-Blind, Placebo-controlled Study

Background Low concentrations of hypochlorous acid (HOCl) have proven antipruritic, anti-inflammatory, and antimicrobial effects without toxicity, although the mechanism has not been fully elucidated. Objective The aim of this study was to evaluate the effectiveness of HOCl nasal irrigation to reduce allergic rhinitis (AR) symptoms compared with saline nasal irrigation. Methods This was multicenter, randomized, double-blind, placebo-controlled study. Initially, 139 patients with perennial AR were enrolled; however, 25 did not successfully complete the study. Patients were randomly assigned to the nasal irrigation with low-concentration HOCl (n = 55) or normal saline (n = 59) treatment groups for the 4-week study period. Participants completed the Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ) at every visit (baseline, Weeks 2 and 4), and Total Nasal Symptom Score (TNSS) was determined before and after nasal irrigation every morning and evening. Results We found that RQLQ scores significantly decreased after 4 weeks in the HOCl and placebo groups, but the decrement of the RQLQ score was similar between the 2 groups. Additionally, TNSS improved in both groups between baseline and Week 4, whereas there were no significant differences in the change of TNSS between the 2 groups. The HOCl group did not show any clinical side effects related to nasal irrigation. Conclusion Allergic symptoms significantly decreased with low-concentration HOCl nasal irrigation, without significant adverse events. However, HOCl showed no additional improvement in symptoms compared with saline nasal irrigation for patients with perennial AR.

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Loratadine/Pseudoephedrine for Nasal Symptoms in Seasonal Allergic Rhinitis: A Double-Blind, Placebo-Controlled Study

Ear Nose & Throat Journal ◽

10.1177/014556130007900410 ◽

2000 ◽

Vol 79 (4) ◽

pp. 254-267 ◽

Cited By ~ 11

Author(s):

Edith A. McFadden ◽

Anil Gungor ◽

Bernard Ng ◽

Bülent Mamikoglu ◽

Rizwan Moinuddin ◽

...

Keyword(s):

Allergic Rhinitis ◽

Seasonal Allergic Rhinitis ◽

Fixed Combination ◽

Nasal Congestion ◽

Inferior Turbinate ◽

Controlled Study ◽

Life Questionnaire ◽

Double Blind ◽

Double Blind Placebo ◽

Nasal Symptoms

In this double-blind, placebo-controlled, crossover, parallel study, we treated 20 adults who had seasonal allergic rhinitis with once-daily fixed-combination loratadine/pseudoephedrine sulfate to observe its effect on relieving symptoms, primarily nasal congestion. Acoustic rhinometry detected a trend toward improvement in nasal patency, although the difference between pre- and post-treatment measures was not statistically significant. Endoscopic inferior turbinate photography documented that treatment led to statistically significant reductions in the amount of nasal edema and nasal secretions. The results of a quality-of-life questionnaire suggested that treatment alleviated nasal and ocular symptoms of rhinoconjunctivitis. An analysis of subjective visual analog scale scores showed a trend toward improvement in most but not all nasal symptoms. We conclude that once-a-day fixed-combination loratadine/pseudoephedrine is effective in relieving nasal congestion in patients with seasonal allergic rhinitis.

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Intralymphatic immunotherapy with tyrosine-adsorbed allergens: a double-blind, placebo-controlled trial

Respiratory Research ◽

10.1186/s12931-021-01766-0 ◽

2021 ◽

Vol 22 (1) ◽

Author(s):

Hye Jung Park ◽

Sae-Hoon Kim ◽

Yoo Seob Shin ◽

Chul Hwan Park ◽

Eun-Suk Cho ◽

...

Keyword(s):

Allergic Rhinitis ◽

Injection Site ◽

Symptom Score ◽

Therapeutic Efficacy ◽

Controlled Trial ◽

Life Questionnaire ◽

Double Blind ◽

Double Blind Placebo ◽

Medication Score ◽

Allergen Extracts

Abstract Background Most previous studies used aluminum hydroxide-absorbed allergen extracts in evaluating the potential therapeutic roles of intralymphatic allergen-specific immunotherapy (ILAIT). In this study, we evaluated the therapeutic efficacy and safety of ILAIT with L-tyrosine-adsorbed allergen extracts of Dermatophagoides farinae, D. pteronyssinus, cat, dog, or mixtures thereof, in patients with allergic rhinitis induced by these allergens. Methods In this randomized, double-blind, placebo-controlled trial, study subjects received three intralymphatic injections of L-tyrosine-adsorbed allergen extracts (active group) or saline (placebo group) at 4-week intervals. Results Although ILAIT reduced daily medication use and skin reactivity to HDM and cat allergens at 4 months after treatment, overall symptom score on a visual analog scale (VAS), sinonasal outcome test-20 (SNOT-20), rhinoconjunctivitis quality of life questionnaire (RQLQ), daily symptom score (dSS), daily medication score (dMS), daily symptom medication score (dSMS), nasal reactivity to HDM allergen, and basophil activity to HDM, cat, and dog allergens at 4 months and 1 year after treatment were similar between the treatment and control groups. Intralymphatic injection was more painful than a venous puncture, and pain at the injection site was the most frequent local adverse event (12.8%); dyspnea and wheezing were the most common systemic adverse events (5.3%). Conclusions ILAIT with L-tyrosine-adsorbed allergen extracts does not exhibit profound therapeutic efficacy in allergic rhinitis and can provoke moderate-to-severe systemic reactions and cause pain at the injection site. Trial registration: clinicaltrials.gov: NCT02665754; date of registration: 28 January 2016

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Nebulized Beclomethasone In The Treatment Of Childhood Mild Intermittent Asthma With Seasonal Allergic Rhinitis. A Randomized, Double-Blind, Placebo-Controlled Study

10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a4433 ◽

2011 ◽

Author(s):

Mirella Profita ◽

Loredana Riccobono ◽

Anna Bonanno ◽

Rosalia Gagliardo ◽

Mark Gjomarkaj ◽

...

Keyword(s):

Allergic Rhinitis ◽

Seasonal Allergic Rhinitis ◽

Controlled Study ◽

Double Blind ◽

Double Blind Placebo ◽

Intermittent Asthma

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Rupatadine oral solution in children with persistent allergic rhinitis: A randomized, double-blind, placebo-controlled study

Pediatric Allergy and Immunology ◽

10.1111/pai.12036 ◽

2013 ◽

Vol 24 (2) ◽

pp. 144-150 ◽

Cited By ~ 15

Author(s):

Paul Potter ◽

Jorge F. Maspero ◽

Jan Vermeulen ◽

László Barkai ◽

Ildikó Németh ◽

...

Keyword(s):

Allergic Rhinitis ◽

Oral Solution ◽

Controlled Study ◽

Double Blind ◽

Double Blind Placebo ◽

Persistent Allergic Rhinitis

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Oral Desensitization in Papular Urticaria in Children

Tropical Doctor ◽

10.1177/004947550203200307 ◽

2002 ◽

Vol 32 (3) ◽

pp. 142-145 ◽

Cited By ~ 2

Author(s):

Susana Giraldi ◽

Ramón Ruiz-Maldonado ◽

Lourdes Tamayo ◽

Cristina Sosa-de-Martínez

Keyword(s):

Vaccine Efficacy ◽

Oral Vaccine ◽

Effective Means ◽

Controlled Study ◽

Double Blind ◽

Double Blind Placebo ◽

Before And After ◽

Insect Bites ◽

Oral Desensitization

Papular urticaria (PU) is among the commonest skin ailments in children. Induced specific desensitization to insect bites is theoretically an effective means of prevention of PU. In this double blind placebo controlled study, an oral vaccine prepared from insect saliva was compared with placebo (stable vaccine solvent). Vaccine and placebo effectiveness were tested by counting active PU lesions, serum eosinophils, and IgE, before and after 4 months of treatment. Statistically significant differences between oral vaccine and placebo were not found in the clinical or the immunological variables tested. We conclude that, although a lack of oral vaccine efficacy was suspected, larger study samples are needed to strengthen our conclusion.

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