scholarly journals Immunosuppressant therapeutic drug monitoring and trough level stabilisation after paediatric liver or kidney transplantation

2019 ◽  
Author(s):  
Klara M. Posfay-Barbe ◽  
Henri Baudet ◽  
Valrie A. McLin ◽  
Paloma Parvex ◽  
Hassib Chehade ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Therapeutic Drug Monitoring ◽  
Drug Monitoring ◽  
Trough Level ◽  
Therapeutic Drug

Therapeutic drug monitoring of tacrolimus in kidney transplantation: 9-month follow–up

1998 ◽  
Vol 30 (8) ◽  
pp. 4068-4069 ◽  
Author(s):  
M Brunet ◽  
J.V Torregrosa ◽  
F Oppenheimer ◽  
J Corbella
Keyword(s):  
Kidney Transplantation ◽  
Therapeutic Drug Monitoring ◽  
Drug Monitoring ◽  
Therapeutic Drug

Therapeutic drug monitoring of mycophenolates in kidney transplantation: report of The Transplantation Society consensus meeting

2011 ◽  
Vol 25 (2) ◽  
pp. 58-64 ◽  
Author(s):  
Yannick Le Meur ◽  
Richard Borrows ◽  
Mark D. Pescovitz ◽  
Klemens Budde ◽  
Josep Grinyo ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Therapeutic Drug Monitoring ◽  
Drug Monitoring ◽  
Consensus Meeting ◽  
Therapeutic Drug ◽  
Transplantation Society

Tacrolimus Therapeutic Drug Monitoring in Stable Kidney Transplantation and Individuation of CYP3A5 Genotype

2019 ◽  
Vol 51 (9) ◽  
pp. 2917-2920 ◽  
Author(s):  
L. Allegri ◽  
F. Baldan ◽  
C. Vallone ◽  
P. Tulissi ◽  
M. Gropuzzo ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Therapeutic Drug Monitoring ◽  
Drug Monitoring ◽  
Therapeutic Drug ◽  
Cyp3a5 Genotype

The role of therapeutic drug monitoring in the treatment of cytomegalovirus disease in kidney transplantation

2012 ◽  
Vol 45 (6) ◽  
pp. 1809-1813 ◽  
Author(s):  
Giulia Bedino ◽  
Pasquale Esposito ◽  
Francesca Bosio ◽  
Valeria Corradetti ◽  
Teresa Valsania ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Therapeutic Drug Monitoring ◽  
Drug Monitoring ◽  
Therapeutic Drug ◽  
Cytomegalovirus Disease

A Therapeutic Drug Monitoring Algorithm for Refining the Imatinib Trough Level Obtained at Different Sampling Times

2009 ◽  
Vol 31 (5) ◽  
pp. 579-584 ◽  
Author(s):  
Yanfeng Wang ◽  
Yen Lin Chia ◽  
Jerry Nedelman ◽  
Horst Schran ◽  
Francois-Xavier Mahon ◽  
...  
Keyword(s):  
Therapeutic Drug Monitoring ◽  
Drug Monitoring ◽  
Trough Level ◽  
Therapeutic Drug ◽  
Sampling Times ◽  
Monitoring Algorithm

scholarly journals Recommended initial loading dose of teicoplanin, established by therapeutic drug monitoring, and outcome in terms of optimal trough level

2006 ◽  
Vol 12 (4) ◽  
pp. 185-189 ◽  
Author(s):  
Masaki Sato ◽  
Kingo Chida ◽  
Takafumi Suda ◽  
Hitoshi Gemma ◽  
Hirotoshi Nakamura ◽  
...  
Keyword(s):  
Therapeutic Drug Monitoring ◽  
Drug Monitoring ◽  
Trough Level ◽  
Therapeutic Drug ◽  
Loading Dose ◽  
Initial Loading

Therapeutic Drug Monitoring of Belatacept in Kidney Transplantation

2015 ◽  
Vol 37 (5) ◽  
pp. 560-567 ◽  
Author(s):  
Gretchen N. de Graav ◽  
Stein Bergan ◽  
Carla C. Baan ◽  
Willem Weimar ◽  
Teun van Gelder ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Therapeutic Drug Monitoring ◽  
Drug Monitoring ◽  
Therapeutic Drug

Voriconazole Autoinduction and Saturable Metabolism After Cessation of Rifampin in a Patient With Invasive Central Nervous System Aspergillus: Importance of Therapeutic Drug Monitoring

2018 ◽  
Vol 32 (5) ◽  
pp. 589-594 ◽  
Author(s):  
Salia Farrokh ◽  
Edina Avdic
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Therapeutic Drug Monitoring ◽  
Drug Monitoring ◽  
Critically Ill Patients ◽  
Trough Level ◽  
Therapeutic Drug ◽  
High Dose ◽  
Frequent Dose ◽  
Intrapatient Variability

Purpose: Optimization of antifungal therapy with voriconazole can be challenging due to inter- and intrapatient variability in voriconazole pharmacokinetics (PK). In this case, we introduce challenges in voriconazole therapy due to drug–drug interactions, autoinduction, and saturable metabolism. Summary: A 32-year-old male on chronic prednisone developed central nervous system (CNS) aspergillosis. He was started on high-dose intravenous (IV) voriconazole 8.5 mg/kg every 12 hours due to concerns for lasting induction effects of recent rifampin therapy. The initial voriconazole trough was 2 μg/mL. Frequent dose adjustments were made to maintain the therapeutic trough goal. On day 24 of voriconazole therapy, his trough was undetectable on IV voriconazole 5.5 mg/kg every 12 hours. His dose was escalated to 8.5 mg/kg every 12 hours to avoid subtherapeutic levels and therapeutic failure. On day 48, his trough level was 1.1 μg/mL on the same dose. His regimen was changed to 6.5 mg/kg every 8 hours at this point. Sixteen days after this regimen on day 74 of voriconazole therapy, his trough was 27.2 μg/mL indicating saturable PK of voriconazole in the absence of interacting drugs. Conclusion: Our findings highlight the unpredictable PK of voriconazole and reinforce the importance of continuous therapeutic drug monitoring in critically ill patients.

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