scholarly journals Late Onset Systemic Lupus Erythematosus in an Afro-Caribbean Patient: A Diagnostic Challenge

2018 ◽  
Vol 1 (2) ◽  
pp. 84-89
Author(s):  
Barrett-Campbell Odeth ◽  
◽  
James-Goulbourne Tracian ◽  
Shapira Iuliana ◽  
◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Elderly Population ◽  
Late Onset ◽  
The Elderly ◽  
Chronic Illnesses ◽  
Systemic Lupus ◽  
Diagnostic Challenge ◽  
Caribbean Woman ◽  
Onset Systemic Lupus Erythematosus

Systemic Lupus Erythematosus may be missed in the elderly population as the clinical features may resemble more common conditions. Treatment remains a challenge in this group given the co-existing chronic illnesses and drug-related toxicities. Herein, we report a case of a 72-year-old Afro-Caribbean woman diagnosed with systemic lupus erythematosus after having pulmonary and renal manifestations.

scholarly journals Features of late-onset systemic lupus erythematosus

2021 ◽  
Vol 30 (3) ◽  
pp. 121-124
Author(s):  
Alexandra Constantinescu ◽  
◽  
Claudia Cobilinschi ◽  
Elena Gradinaru ◽  
Ioana Saulescu ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Late Onset ◽  
Systemic Lupus ◽  
Diagnostic Challenge ◽  
Disease Subtype ◽  
Distinct Disease ◽  
Physician Awareness ◽  
Chronic Autoimmune Disease ◽  
Onset Systemic Lupus Erythematosus

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease, characterized by multiorgan involvement, most commonly targeting the skin, joints and kidneys. Late-onset disease occurs in patients over the age of 50 and represents a diagnostic challenge, as it is less frequently encountered and it may exhibit a more unusual clinical and paraclinical picture. The aim of this paper is to highlight two cases of SLE diagnosed in female patients of considerably advanced ages, 81 and 72 years respectively, in order to enhance physician awareness with regard to this distinct disease subtype.

Autoimmune hepatitis complicated by late-onset systemic lupus erythematosus

2007 ◽  
Vol 37 (9) ◽  
pp. 771-774 ◽  
Author(s):  
Atsushi Takahashi ◽  
Tsuyoshi Rai ◽  
Michio Onizawa ◽  
Kyoko Monoe ◽  
Yukiko Kanno ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Autoimmune Hepatitis ◽  
Lupus Erythematosus ◽  
Late Onset ◽  
Systemic Lupus ◽  
Onset Systemic Lupus Erythematosus

scholarly journals Severe pleuritis and pericarditis associated with very-late-onset systemic lupus erythematosus

2018 ◽  
Vol 19 (2) ◽  
pp. 53-56
Author(s):  
Hiroaki Ikushima ◽  
Akihiko Mitsutake ◽  
Takuto Hideyama ◽  
Tatsuya Sato ◽  
Junko Katsumata ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Late Onset ◽  
Systemic Lupus ◽  
Onset Systemic Lupus Erythematosus

scholarly journals Diffuse Bullous Eruptions in an Elderly Woman: Late-Onset Bullous Systemic Lupus Erythematosus

2016 ◽  
Vol 8 (3) ◽  
pp. 278-282 ◽  
Author(s):  
Prajwal Boddu ◽  
Mojtaba Nadiri ◽  
Owais Malik
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Late Onset ◽  
Clinical History ◽  
The Elderly ◽  
Direct Immunofluorescence ◽  
Systemic Lupus ◽  
Diverse Range ◽  
American College Of Rheumatology ◽  
Type Vii Collagen

Vesiculobullous eruptions in the elderly represent a diverse range of varying pathophysiologies and can present a significant clinical dilemma to the diagnostician. Diagnosis requires a careful review of clinical history, attention to detail on physical and histomorphological examination, and appropriate immunofluorescence testing. We describe the case of a 73-year-old female who presented to our hospital with a painful blistering skin rash developed over 2 days. Examination of the skin was remarkable for numerous flaccid hemorrhagic bullae on a normal-appearing nonerythematous skin involving both the upper and lower extremities. Histopathology of the biopsy lesion showed interface change at the epidermo-dermal region with subepidermal blister formation, mild dermal fibrosis, and sparse interstitial neutrophilic infiltrate. Immunohistological analysis was significant for positive IgG basement membrane zone antibodies with a dermal pattern of localization on direct immunofluorescence and positive IgG antinuclear antibodies on indirect immunofluorescence. Evidence of antibodies to type VII collagen suggested the diagnosis of epidermolysis bullosa acquisita versus bullous systemic lupus erythematosus (BSLE). A diagnosis of BSLE was made based on positive American College of Rheumatology criteria, acquired vesiculo-bullous eruptions with compatible histopathological and immunofluorescence findings. This case illustrates one of many difficulties a physician encounters while arriving at a diagnosis from a myriad of immunobullous dermatoses. Also, it is important for internists and dermatologists alike to be aware of and differentiate this uncommon and nonspecific cutaneous SLE manifestation from a myriad of disorders presenting with vesiculobullous skin eruptions in the elderly.

Late-onset systemic lupus erythematosus in Latin Americans: a distinct subgroup?

Lupus ◽  
2014 ◽  
Vol 24 (8) ◽  
pp. 788-795 ◽  
Author(s):  
L J Catoggio ◽  
E R Soriano ◽  
P M Imamura ◽  
D Wojdyla ◽  
S Jacobelli ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Late Onset ◽  
Systemic Lupus ◽  
Latin Americans ◽  
Distinct Subgroup ◽  
Onset Systemic Lupus Erythematosus
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