scholarly journals Vgkc Encephalitis With Low-Titer Antibodies: Case Report

2020 ◽  
pp. 1-3
Author(s):  
Sena Aksoy ◽  
◽  
Mina Uzülmez ◽  
Aysun Soysal ◽  
◽  
...  
Keyword(s):  
Case Report ◽  
Potassium Channel ◽  
Memory Impairment ◽  
Psychiatric Symptoms ◽  
Autoimmune Encephalitis ◽  
Voltage Gated ◽  
With Memory

Voltage-gated potassium channel (VGKC) encephalitis is a type of autoimmune encephalitis, that presents with memory impairment, headache, psychiatric symptoms and seizures. Although contactin-associated protein 2 (CASPR2) and leucine-rich glioma inactivated 1 (LGI1) are clearly identifed as components of the VGKC complex, additional subtypes are known to exist. In this report, we present a case of 64-year-old patient with VGKC antibodies, negative for CASPR2 and LGI1

scholarly journals Psychiatric presentation of voltage-gated potassium channel antibody-associated encephalopathy

2006 ◽  
Vol 189 (2) ◽  
pp. 182-183 ◽  
Author(s):  
U. D. Parthasarathi ◽  
T. Harrower ◽  
M. Tempest ◽  
J. R. Hodges ◽  
C. Walsh ◽  
...  
Keyword(s):  
Potassium Channels ◽  
Potassium Channel ◽  
Memory Impairment ◽  
Psychiatric Symptoms ◽  
Epileptic Seizures ◽  
Complete Recovery ◽  
Panic Attacks ◽  
Voltage Gated ◽  
With Memory

SummaryVoltage-gated potassium channel antibody encephalopathy, a rare cause of limbic encephalopathy, typically presents with memory impairment and seizures. Psychiatric symptoms have not been emphasised in the literature. Here we describe a 58-year-old man who presented with panic attacks and psychogenic non-epileptic seizures and, later on, developed delusions and hallucinations and then confusion. He was found to have antibodies to voltage-gated potassium channels. Treatment with immuno-modulatory therapy resulted in almost complete recovery.

Voltage-gated potassium channel limbic encephalitis presenting as functional cognitive impairment

2020 ◽  
Vol 13 (12) ◽  
pp. e233179
Author(s):  
Eric Garrels ◽  
Fawziya Huq ◽  
Gavin McKay
Keyword(s):  
Cognitive Impairment ◽  
Case Report ◽  
Potassium Channel ◽  
Limbic Encephalitis ◽  
Psychiatric Symptoms ◽  
Differential Diagnoses ◽  
Visual Hallucinations ◽  
Voltage Gated ◽  
History Of ◽  
Impaired Cognition

Limbic encephalitis is often reported to present as seizures and impaired cognition with little focus on psychiatric presentations. In this case report, we present a 49-year-old man who initially presented to the Psychiatric Liaison Service with a several month history of confusion with the additional emergence of visual hallucinations and delusions. Due to the inconsistent nature of the symptoms in the context of a major financial stressor, a provisional functional cognitive impairment diagnosis was made. Investigations later revealed a positive titre of voltage-gated potassium channel (VGKC) antibodies, subtype leucine-rich glioma inactivated 1 accounting for his symptoms which dramatically resolved with steroids and immunoglobulins. This case highlighted the need for maintaining broad differential diagnoses in a patient presenting with unusual psychiatric symptoms.

Sporadic Creutzfeldt-Jakob disease mimic due to voltage gated potassium channel antibodies (VGKC) autoimmune encephalitis. (case report)

2019 ◽  
Vol 405 ◽  
pp. 91
Author(s):  
W. Trillo Alvarez ◽  
J.A. Medina Suarez ◽  
J.J. Molina Acosta ◽  
C.R. Ibañez Escalante ◽  
A.Z. Escalante Mercado
Keyword(s):  
Case Report ◽  
Potassium Channel ◽  
Autoimmune Encephalitis ◽  
Voltage Gated ◽  
Jakob Disease

scholarly journals Gain-of-function mutation in the voltage-gated potassium channel gene KCNQ1 and glucose-stimulated hypoinsulinemia - case report

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Jinyi Zhang ◽  
Christian R. Juhl ◽  
Louise Hylten-Cavallius ◽  
Morten Salling-Olsen ◽  
Allan Linneberg ◽  
...  
Keyword(s):  
Case Report ◽  
Potassium Channel ◽  
Gain Of Function ◽  
Voltage Gated ◽  
Channel Gene ◽  
Potassium Channel Gene

scholarly journals Anti-NMDA Encephalitis: A Rare Encephalitis in a Child- A Case Report

2020 ◽  
Vol 19 (2) ◽  
pp. 108-111
Author(s):  
Saurav Khetan ◽  
Nikhil Agrawal ◽  
Prakash Rajoli
Keyword(s):  
Case Report ◽  
Japanese Encephalitis ◽  
Viral Encephalitis ◽  
Psychiatric Symptoms ◽  
Autoimmune Encephalitis ◽  
High Index ◽  
First Case ◽  
High Index Of Suspicion

Anti-NMDA encephalitis is second commonest cause of autoimmune encephalitis among children; however, it is hardly diagnosed and often not considered as one of the differentials when a child presents with encephalitis-related symptoms. In children, it presents mostly with seizures or psychiatric symptoms without prodrome. Here we present a six years old girl who presented with seizures and inappropriate behaviour. We investigated her in the line of viral encephalitis such as Japanese Encephalitis, which is very common in our region. However, results were not suggestive of Japanese Encephalitis and further investigations subsequently lead to diagnosis of anti- NMDA encephalitis. This is probably one of the first case report of this disease in our country. We want to highlight the significance of high index of suspicion for looking out for an organic cause in any child who presents with psychiatric symptoms, along with seizures.

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