Rhesus Blood Group System

Rhnull human erythrocytes lack the antigens of the Rhesus blood-group system, have an abnormal shape, have an increased osmotic fragility, and are associated with mild chronic haemolytic anaemia. Rhnull erythrocytes also lack all antigens of the LW blood-group system, but the functional significance of this deficiency is unknown. We have identified, by immunoblotting with two mouse monoclonal antibodies (BS46 and BS56), the LW-active component(s) in normal human erythrocytes as a broad band of Mr 37 000-47 000 on SDS/polyacrylamide-gel electrophoresis. Treatment of intact human erythrocytes with endoglycosidase F preparation destroyed the epitopes recognized by antibodies BS46 and BS56, suggesting that one or more N-glycosidically linked oligosaccharides are required for the formation of the LW antigens. Estimation of the number of LW antigen sites per erythrocyte by using radioiodinated purified antibody BS46 gave average values of 4400 molecules/cell for Rh(D)-positive adult erythrocytes and 2835 molecules/cell for Rh(D)-negative adult erythrocytes. Like the Rh(D) polypeptide, the LW polypeptide(s) is (are) associated with the cytoskeleton of normal erythrocytes. These results suggest the possibility that the absence of the LW polypeptide may also contribute to the functional and/or morphological abnormalities of Rhnull erythrocytes.

Download Full-text

A selection model for the rhesus blood-group system

Journal of Human Evolution ◽

10.1016/s0047-2484(77)80118-8 ◽

1977 ◽

Vol 6 (2) ◽

pp. 135-140 ◽

Cited By ~ 1

Author(s):

G. Flatz ◽

H.-B. Brinkmann

Keyword(s):

Blood Group ◽

Selection Model ◽

Blood Group System ◽

Group System ◽

Rhesus Blood Group ◽

Rhesus Blood Group System

Download Full-text

Rhesus blood group system

Dictionary of Rheumatology ◽

10.1007/978-3-211-79280-3_980 ◽

2009 ◽

pp. 185-185

Keyword(s):

Blood Group ◽

Blood Group System ◽

Group System ◽

Rhesus Blood Group ◽

Rhesus Blood Group System

Download Full-text

Physiology of ABO and Rhesus Blood Group System and its Prevalence and Correlation with Possible Transmission of Infections During Screening in Hassan District

International Journal of Physiology ◽

10.5958/2320-608x.2017.00081.6 ◽

2017 ◽

Vol 5 (2) ◽

pp. 173

Author(s):

T R Yathish ◽

R Purushotham ◽

S Sudhanva ◽

C R Sudharshan

Keyword(s):

Blood Group ◽

Blood Group System ◽

Group System ◽

Rhesus Blood Group ◽

Rhesus Blood Group System

Download Full-text

Genetic Analysis of ABO and Rh Blood Groups in Backward Caste Population of Uttar Pradesh, India

Notulae Scientia Biologicae ◽

10.15835/nsb336073 ◽

2011 ◽

Vol 3 (3) ◽

pp. 07-14 ◽

Cited By ~ 2

Author(s):

Vandana RAI ◽

Pradeep KUMAR

Keyword(s):

Blood Group ◽

Uttar Pradesh ◽

Blood Groups ◽

Blood Type ◽

Allele Frequency Distribution ◽

Blood Group System ◽

Blood Group Antigens ◽

Group System ◽

Rhesus Blood Group ◽

Rhesus Blood Group System

A series of glycoproteins and glycolipids on red blood cell surface constitute blood group antigens. These are AB, A, B and O in ABO blood group system and Rh in rhesus blood group system. A total of 1065 unrelated Backward Caste (OBC) individuals from Uttar Pradesh were studied for the phenotype and allele frequency distribution of ABO and Rh (D) blood groups. Total 1065 samples analyzed, phenotype B blood type has the highest frequency 36.81% (n=392), followed by O (32.68%; n=348), A (23.66%; n=252) and AB (6.85%; n=73). The overall phenotypic frequencies of ABO blood groups were B>O>A>AB. The allelic frequencies of O, A, and B alleles were 0.5819, 0.1674 and 0.2506 respectively. Out of total 1065 samples, 1018 (95.59%) samples were Rh-positive and 47 (4.41%) were Rh-negative. Phenotypic frequency of Rh-negative in Koari, Yadav, Kurmi and Maurya samples were 0.99%, 4%, 1.4% and 7.6% respectively.

Download Full-text