Retinal Nerve Fiber Layer Thickness by Stratus and Cirrus OCT in Retrobulbar Optic Neuritis and Nonarteritic Ischemic Optic Neuropathy

2016 ◽  
Vol 27 (1) ◽  
pp. 80-85 ◽  
Author(s):  
Barbara Giambene ◽  
Gianni Virgili ◽  
Ugo Menchini
Keyword(s):  
Confidence Interval ◽  
Optic Neuritis ◽  
Nerve Fiber ◽  
Layer Thickness ◽  
Optic Neuropathy ◽  
Ischemic Optic Neuropathy ◽  
Fiber Layer ◽  
Nerve Fiber Layer Thickness ◽  
Cirrus Oct ◽  
Retrobulbar Optic Neuritis

Purpose To compare retinal nerve fiber layer thickness (RNFLT) measurements by Stratus and Cirrus optical coherence tomography (OCT) and to evaluate agreement between the 2 instruments in retrobulbar optic neuritis (RON), nonarteritic ischemic optic neuropathy (NAION), and healthy controls. Methods A total of 89 eyes with RON, 92 with NAION (6 to 12 months after diagnosis of acute disease), and 159 control eyes were studied. Average RNFLT was measured by Stratus and Cirrus OCTs. Comparisons among groups were performed by analysis of variance. Agreement between the 2 instruments was assessed using intraclass correlation coefficient (ICC) with 95% confidence interval (CI) and Bland-Altman analysis. Statistical significance was set at p≤0.05. Results Average RNFLT was lower in NAION eyes than in RON and control ones using both OCT devices (60.0 ± 1.2, 69.9 ± 1.2, and 97.4 ± 0.9 μm, p<0.001 by Cirrus; 49.7 ± 1.5, 65.9 ± 1.9, and 99.2 ± 1.3 μm, p<0.001 by Stratus). The RNFLT values were higher with Cirrus than with Stratus in NAION (+10.30 μm, confidence interval [CI] 7.82-12.79 μm) and RON (+4.01 μm, CI 1.32-6.70 μm) eyes, and slightly lower in control ones (-1.75 μm, CI -3.51 to 0.01 μm). A stronger agreement between the 2 instruments was found in control and RON eyes than in NAION ones (ICC 0.682, CI 0.566-0.771; 0.635, CI 0.467-0.758; 0.321, CI 0.132-0.472, respectively). Conclusions Both Stratus and Cirrus OCT can identify RNFLT reduction in previous RON and NAION. Absolute RNFLT values differ between the 2 instruments; hence they are not to be considered interchangeable.

scholarly journals Optic Disc and Retinal Nerve Fiber Layer Thickness Evaluation of the Fellow Eyes in Non-Arteritic Ischemic Optic Neuropathy

2015 ◽  
Vol 45 (3) ◽  
pp. 111-114 ◽  
Author(s):  
Medine Yılmaz Dağ ◽  
Elif Demirkılınç Biler ◽  
Zerrin Alkan ◽  
Önder Üretmen ◽  
Süheyla Köse ◽  
...  
Keyword(s):  
Nerve Fiber ◽  
Layer Thickness ◽  
Optic Disc ◽  
Optic Neuropathy ◽  
Retinal Nerve Fiber Layer ◽  
Ischemic Optic Neuropathy ◽  
Fiber Layer ◽  
Nerve Fiber Layer Thickness ◽  
Thickness Evaluation ◽  
Fellow Eyes

Optic Disc Topography and Peripapillary Retinal Nerve Fiber Layer Thickness in Nonarteritic Ischemic Optic Neuropathy and Open-Angle Glaucoma

Ophthalmology ◽  
2006 ◽  
Vol 113 (8) ◽  
pp. 1340-1344 ◽  
Author(s):  
Hitomi Saito ◽  
Atsuo Tomidokoro ◽  
Eiichiro Sugimoto ◽  
Makoto Aihara ◽  
Goji Tomita ◽  
...  
Keyword(s):  
Nerve Fiber ◽  
Layer Thickness ◽  
Optic Disc ◽  
Optic Neuropathy ◽  
Retinal Nerve Fiber Layer ◽  
Open Angle Glaucoma ◽  
Ischemic Optic Neuropathy ◽  
Open Angle ◽  
Fiber Layer ◽  
Nerve Fiber Layer Thickness

Retinal nerve fiber layer thickness in nonarteritic anterior ischemic optic neuropathy: OCT characterization of the acute and resolving phases

2008 ◽  
Vol 246 (5) ◽  
pp. 641-647 ◽  
Author(s):  
Costantino Bellusci ◽  
Giacomo Savini ◽  
Michele Carbonelli ◽  
Valerio Carelli ◽  
Alfredo A. Sadun ◽  
...  
Keyword(s):  
Nerve Fiber ◽  
Layer Thickness ◽  
Optic Neuropathy ◽  
Retinal Nerve Fiber Layer ◽  
Anterior Ischemic Optic Neuropathy ◽  
Ischemic Optic Neuropathy ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Nerve Fiber Layer Thickness

Tracking retinal nerve fiber layer loss after optic neuritis: a prospective study using optical coherence tomography

2008 ◽  
Vol 14 (7) ◽  
pp. 893-905 ◽  
Author(s):  
F Costello ◽  
W Hodge ◽  
YI Pan ◽  
E Eggenberger ◽  
S Coupland ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Optic Neuritis ◽  
Nerve Fiber ◽  
Layer Thickness ◽  
Retinal Nerve Fiber Layer ◽  
Optical Coherence ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Nerve Fiber Layer Thickness ◽  
Retinal Nerve Fiber

Introduction Optic neuritis causes retinal nerve fiber layer damage, which can be quantified with optical coherence tomography. Optical coherence tomography may be used to track nerve fiber layer changes and to establish a time-dependent relationship between retinal nerve fiber layer thickness and visual function after optic neuritis. Methods This prospective case series included 78 patients with optic neuritis, who underwent optical coherence tomography and visual testing over a mean period of 28 months. The main outcome measures included comparing inter-eye differences in retinal nerve fiber layer thickness between clinically affected and non-affected eyes over time; establishing when RNFL thinning stabilized after optic neuritis; and correlating retinal nerve fiber layer thickness and visual function. Results The earliest significant inter-eye differences manifested 2-months after optic neuritis, in the temporal retinal nerve fiber layer. Inter-eye comparisons revealed significant retinal nerve fiber layer thinning in clinically affected eyes, which persisted for greater than 24 months. Retinal nerve fiber thinning manifested within 6 months and then stabilized from 7 to 12 months after optic neuritis. Regression analyses demonstrated a threshold of nerve fiber layer thickness (75μm), which predicted visual recovery after optic neuritis. Conclusions Retinal nerve fiber layer changes may be tracked and correlated with visual function within 12 months of an optic neuritis event.

Retinal nerve fiber layer and ganglion cell complex thickness as a diagnostic tool in early stage dysthyroid optic neuropathy

2021 ◽  
pp. 112067212110620
Author(s):  
Lihua Luo ◽  
Dongmei Li ◽  
Lixin Gao ◽  
Wei Wang
Keyword(s):  
Ganglion Cell ◽  
Nerve Fiber ◽  
Layer Thickness ◽  
Optic Neuropathy ◽  
Cell Complex ◽  
Ganglion Cell Complex ◽  
Fiber Layer ◽  
Dysthyroid Optic Neuropathy ◽  
Nerve Fiber Layer ◽  
Nerve Fiber Layer Thickness

Purpose To compare the diagnostic accuracy of peripapillary retinal nerve fiber layer with macular ganglion cell complex thickness as an auxiliary tool for the early diagnosis of dysthyroid optic neuropathy and help assess the effectiveness of the treatment. Methods In this retrospective case–control study, a total of 58 thyroid-associated opthalmopathy patients and 58 healthy participants were enrolled in the study. Thyroid-associated opthalmopathy patients were divided according to the European Group Graves’ Orbitopathy severity classification. The thicknesses of peripapillary nerve fiber layer and macular ganglion cell complex were measured using optical coherence tomography and their correlation with the severity of the disease as well as the effect of the treatment was investigated. Results No statistically significant differences were found between the mild thyroid-associated opthalmopathy group and the control group in both peripapillary nerve fiber layer and macular ganglion cell complex thickness. In the moderate-to-severe thyroid-associated opthalmopathy group, however, Temporal and Nasal peripapillary nerve fiber layer thicknesses were lower compared to the control group ( p = 0.041, p = 0.012), whereas in the sight-threatening thyroid-associated opthalmopathy group Temporal Inferior, Nasal Superior, and mean (G) peripapillary nerve fiber layer thicknesses were larger ( p = 0.000, p = 0.004, p = 0.000). No significant differences were observed in the macular ganglion cell complex thickness among the different severity groups and the control groups ( p > 0.05). After treatment, the mean peripapillary nerve fiber layer thickness decreased whereas mean macular ganglion cell complex thickness showed no significant change in the sight-threatening group. A correlation was established between exophthalmos, best corrected visual acuity, clinical activity score, disease course, and the mean peripapillary nerve fiber layer thickness. The area under curve analysis indicated that mean peripapillary nerve fiber layer thickness can be used as a powerful diagnostic tool in early stage dysthyroid optic neuropathy in thyroid-associated opthalmopathy patients. Conclusion Our study indicates that peripapillary nerve fiber layer act as an auxiliary tool for the early diagnosis of dysthyroid optic neuropathy and helps assess the effectiveness of the treatment.

OCT Retinal Nerve Fiber Layer Thickness Differentiates Acute Optic Neuritis from MOG Antibody-Associated Disease and Multiple Sclerosis

2022 ◽  
pp. 103525
Author(s):  
John J. Chen ◽  
Elias S. Sotirchos ◽  
Amanda D. Henderson ◽  
Eleni S. Vasileiou ◽  
Eoin P. Flanagan ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Optic Neuritis ◽  
Nerve Fiber ◽  
Layer Thickness ◽  
Retinal Nerve Fiber Layer ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Nerve Fiber Layer Thickness ◽  
Acute Optic Neuritis ◽  
Retinal Nerve Fiber
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