Sedative and antiepileptic activity studies on two alternate sources of Tagara

Spatula DD ◽  
2015 ◽  
Vol 5 (3) ◽  
pp. 139
Author(s):  
Jayashree M ◽  
Azharali M ◽  
V Madhavan ◽  
Anita Murali
Keyword(s):  
Antiepileptic Activity

scholarly journals Initial Human Experience with Ganaxolone, a Neuroactive Steroid with Antiepileptic Activity

Epilepsia ◽  
1997 ◽  
Vol 38 (9) ◽  
pp. 1026-1031 ◽  
Author(s):  
Edward P. Monaghan ◽  
Laura A. Navalta ◽  
Linyee Shum ◽  
Donald W. Ashbrook ◽  
David A. Lee
Keyword(s):  
Human Experience ◽  
Neuroactive Steroid ◽  
Antiepileptic Activity

The antiepileptic activity of Vitex agnus castus extract on amygdala kindled seizures in male rats

2008 ◽  
Vol 441 (2) ◽  
pp. 193-196 ◽  
Author(s):  
Mehdi Saberi ◽  
Alireza Rezvanizadeh ◽  
Azam Bakhtiarian
Keyword(s):  
Male Rats ◽  
Antiepileptic Activity ◽  
Agnus Castus ◽  
Kindled Seizures

scholarly journals Antiepileptic activity and subtype-selective action of flupirtine at GABAA receptors

2012 ◽  
Vol 13 (Suppl 1) ◽  
pp. A90
Author(s):  
Mirnes Bajrić ◽  
Felicia Klinger ◽  
Ulla Schandl ◽  
Helmut Kubista ◽  
Stefan Boehm
Keyword(s):  
Gabaa Receptors ◽  
Selective Action ◽  
Antiepileptic Activity ◽  
Subtype Selective

Pentoxifylline Potentiates Antiepileptic Activity of Diazepam on the Model of Treatment-Resistant Focal Epilepsy

2013 ◽  
Vol 154 (3) ◽  
pp. 326-328 ◽  
Author(s):  
L. S. Godlevsky ◽  
G. A. Drozdova ◽  
E. V. Kobolev ◽  
V. F. Mustyatsa ◽  
V. A. Polyasnyi
Keyword(s):  
Focal Epilepsy ◽  
Treatment Resistant ◽  
Antiepileptic Activity

Docking studies and pharmacological evaluation of antiepileptic activity of phytoconstituents

2015 ◽  
Vol 24 (8) ◽  
pp. 3296-3304 ◽  
Author(s):  
Harish S. Kundaikar ◽  
Jayant S. Sancheti ◽  
Pankaj D. Jain ◽  
Mariam S. Degani ◽  
Sadhana Sathaye
Keyword(s):  
Docking Studies ◽  
Antiepileptic Activity ◽  
Pharmacological Evaluation

scholarly journals Antiepileptic activity of preferential inhibitors of persistent sodium current

Epilepsia ◽  
2014 ◽  
Vol 55 (8) ◽  
pp. 1274-1283 ◽  
Author(s):  
Lyndsey L. Anderson ◽  
Christopher H. Thompson ◽  
Nicole A. Hawkins ◽  
Ravi D. Nath ◽  
Adam A. Petersohn ◽  
...  
Keyword(s):  
Sodium Current ◽  
Persistent Sodium Current ◽  
Antiepileptic Activity

scholarly journals Pharmacophoric Analysis of the Structure of a New 1,3,4-Thiadiazolylamide Derivative of Valproic Acid

Medicina ◽  
2020 ◽  
Vol 8 (3) ◽  
pp. 58-66
Author(s):  
A. S. Malygin ◽  
◽  
V. V. Yasnetsov ◽  
Keyword(s):  
Valproic Acid ◽  
Electron Donor ◽  
Amide Group ◽  
Antiepileptic Activity ◽  
Hydrophobic Moiety

Pharmacophoric analysis of the structure of valprazolamide, a 1,3,4-thiadiazolylamide derivative of valproic acid, was carried out. It was shown that the new valproate contains a substituted amide group, hydrophobic and electron-donor domеns – pharmacophores, determining its antiepileptic activity. Valproic acid has only a hydrophobic moiety. Modification of valproic acid by introducing an additional pharmacophore, 1,3,4-thiadiazole, into its structure leads to a decrease in toxicity and an increase in antiepileptic activity.

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