Long non-coding RNA and Notch regulation in non-small cell lung cancer

2020 ◽  
Vol 10 (1) ◽  
pp. 108-122
Author(s):  
Joanna Pancewicz
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Signaling Pathways ◽  
Cancer Progression ◽  
Cell Lung Cancer ◽  
Notch Pathway ◽  
Current Data ◽  
Small Cell ◽  
Small Cell Lung ◽  
Cancer Pathogenesis

Non-small cell lung cancer is one of the most commonly diagnosed cancer with a very high mortality rate. Trying to understand the mechanisms underlying the progression of this type of cancer, it is necessary to evaluate the changes occurring at molecular level in cancer cells. Besides the widely studied signaling pathways and genes which are dysregulated in NSCLC, there is a large group of non-coding RNAs involved in cancer pathogenesis. Those RNAs are tissue specific heterogeneous class of RNAs that play many functions in physiological condition in cells, nevertheless current data has shown that lncRNAs are also functional in different types of cancer. Moreover, it has been suggest that lncRNAs are involved in cancer progression by controlling key signaling pathways involved in diverse types of tumors. Notch signaling is one of those pathways, very often deregulated in NSCLC. Therefore in this review I summarized recent outcomes according the importance of lncRNAs in regulation of Notch pathway in the pathogenesis of NSCLC.

scholarly journals Elevation of EIF4G1 promotes non‐small cell lung cancer progression by activating mTOR signalling

2021 ◽  
Vol 25 (6) ◽  
pp. 2994-3005
Author(s):  
Ying Lu ◽  
Shanshan Yu ◽  
Guangxue Wang ◽  
Zuan Ma ◽  
Xuelian Fu ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cancer Progression ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung ◽  
Mtor Signalling

Autophagy-related signaling pathways in non-small cell lung cancer

2021 ◽  
Author(s):  
Jing Wang ◽  
Mei Gong ◽  
Xirong Fan ◽  
Dalu Huang ◽  
Jinshu Zhang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Signaling Pathways ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung

scholarly journals Interleukin-35 Expression in Non-Small Cell Lung Cancer is Associated with Tumor Progression

2018 ◽  
Vol 51 (4) ◽  
pp. 1839-1851 ◽  
Author(s):  
Mingfei Sun ◽  
Xianjie Zheng ◽  
Qingjiang Meng ◽  
Yanjun Dong ◽  
Guoyu Zhang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cancer Progression ◽  
Cell Lung Cancer ◽  
Disease Free Survival ◽  
Prognostic Indicator ◽  
Small Cell ◽  
Inflammatory Factor ◽  
Small Cell Lung ◽  
Chemotherapy Drugs

Background/Aims: Lung cancer continues to be the leading cause of cancer related deaths worldwide due to its high incidence, malignant behavior and lack of major advancements in treatment strategy. The occurrence and development of lung cancer is closely related to inflammation. Thus, we conducted the present study to investigate the effects of IL-35 (Interleukin 35), a newly identified anti-inflammatory factor, on non-small cell lung cancer (NSCLC), which accounts for about 85% of all lung cancers. Methods: We first evaluated the IL-35 expression in 384 pairs of NSCLC samples and their adjacent normal mucosa by realtime PCR, ELISA (Enzyme-linked immunoassay) and tissue microarrays. Then the role of IL-35 on patient survival rates, cancer progression and their sensitivity to chemotherapy drugs were assessed. Results: IL-35 was barely expressed in the NSCLC tissues but highly expressed in the adjacent normal tissues. The down-regulation of IL-35 was significantly correlated with the results of American Joint Committee on Cancer stage, differentiation and it was also shown to be an independent prognostic indicator of disease-free survival and overall survival for patients with NSCLC. Overexpression of IL-35 in NSCLC cells suppressed cell migration, invasion, proliferation, colony formation through suppressing β-catenin. IL-35 inhibited NSCLC formation in the mice model and sensitize the cancer cells to chemotherapy drugs. Conclusion: Our results showed that IL-35 plays an inhibitory role in NSCLC development and function as a novel prognostic indicator and a potential therapeutic target.

The overexpression of 14-3-3ζ and Hsp27 promotes non-small cell lung cancer progression

Cancer ◽  
2013 ◽  
Vol 120 (5) ◽  
pp. 652-663 ◽  
Author(s):  
Guang-Yin Zhao ◽  
Jian-Yong Ding ◽  
Jie Gu ◽  
Chun-Lai Lu ◽  
Zong-Wu Lin ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cancer Progression ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung

scholarly journals Circular RNA circ_0020123 Promotes Non-Small Cell Lung Cancer Progression Through miR-384/TRIM44 Axis

2021 ◽  
Vol Volume 13 ◽  
pp. 75-87
Author(s):  
Qingshan Ma ◽  
Baogang Huai ◽  
Yuting Liu ◽  
Zhongyao Jia ◽  
Qilong Zhao
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cancer Progression ◽  
Cell Lung Cancer ◽  
Circular Rna ◽  
Small Cell ◽  
Small Cell Lung

scholarly journals YAP1 promotes multidrug resistance of small cell lung cancer by CD74‐related signaling pathways

2019 ◽  
Vol 9 (1) ◽  
pp. 259-268 ◽  
Author(s):  
Yongchun Song ◽  
Yanqin Sun ◽  
Yingying Lei ◽  
Kui Yang ◽  
Ruixiang Tang
Keyword(s):  
Lung Cancer ◽  
Multidrug Resistance ◽  
Small Cell Lung Cancer ◽  
Signaling Pathways ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung
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