scholarly journals In Vitro Dissolution Test for Benzoic Acid Tablets and Prednisolone Tablets in Column-type Method

1976 ◽  
Vol 2 (2) ◽  
pp. 73-83
Author(s):  
OSAMU UMEZAWA ◽  
SACHIKO YAMAMOTO
Keyword(s):  
Benzoic Acid ◽  
In Vitro Dissolution ◽  
Dissolution Test ◽  
Type Method ◽  
Column Type

scholarly journals Development and Validation of an Eco-friendly HPLC-UV-DAD Method for the Determination of Allopurinol in Pharmaceuticals with Application to In vitro Dissolution Studies

2021 ◽  
Vol 11 (5) ◽  
pp. 13089-13101
Keyword(s):  
Factorial Design ◽  
Matrix Effects ◽  
Dissolution Kinetics ◽  
In Vitro Dissolution ◽  
Dissolution Test ◽  
Dissolution Studies ◽  
Dissolution Tests ◽  
Development And Validation

In this study, a sustainable HPLC-UV-DAD method was developed and validated for the determination of allopurinol in tablets and optimization of the dissolution test using factorial design. The separation of the analyte from the sample matrix was achieved in 3.01 minutes in a C8 column (4.6 mm X 150 mm X 5 μm), using mobile phase 0.1 mol L-1 HCl (25%) + ethanol (50%) + ultrapure water (25%) by UV detection at 249 nm. The method presented satisfactory analytical parameters of validation (specificity, selectivity, linearity, stability, precision, accuracy, and robustness), showing no matrix effects. The dissolution test was optimized by complete factorial design 23 and, the optimal conditions were: HCl 0.001 mol L-1, apparatus II (paddle) and 75 rpm. The analytical procedures and dissolution tests were applied to allopurinol tablets marketed in Bahia, Brazil, to evaluate the dissolution studies. The pharmaceuticals had similar dissolution profiles and first-order dissolution kinetics. This new and sustainable HPLC-UV-DAD method is friendly to the environment and can be used for the routine pharmaceutical analysis of allopurinol in fixed dosage forms.

Development of a Two-Compartment System In vitro Dissolution Test and Correlation with In vivo Pharmacokinetic Studies for Celecoxib

2020 ◽  
Vol 21 (2) ◽  
Author(s):  
Shan Jiang ◽  
Guoqing Zhang ◽  
Lei Wang ◽  
Ye Zeng ◽  
Wenjie Liu ◽  
...  
Keyword(s):  
In Vitro Dissolution ◽  
Pharmacokinetic Studies ◽  
Dissolution Test ◽  
Compartment System
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