Percutaneous Intervention Post Coronary Artery Graft Surgery in Patients with Saphenous Vein Graft Disease – State of the Art

Purpose: Saphenous vein graft disease (SVGD), defined as an occlusion of 50% or more of the SVG excluding distal anastomotic occlusion, is an important predictor of morbidity after coronary artery bypass grafting (CABG). Late graft occlusion is a serious complication that often limits the use of the saphenous vein as a coronary bypass graft. Late graft occlusion is particularly common in old, degenerated venous grafts with advanced atherosclerotic plaques. Adropin has been implicated in the homeostatic control of metabolism. The purpose of this study was to investigate whether serum adropin levels are associated with late SVGD following CABG. Methods: Thirty-eight patients with SVGD involving at least one graft (occluded group; 14 females, 24 males) and 42 patients with a patent saphenous vein graft (patent group; 15 females, 27 males) were enrolled in this study. Venous blood samples were taken from all of the participants to measure plasma adropin levels using an enzyme-linked immunsorbent assay kit. Results: The mean adropin level was significantly lower in the occluded group than in the patent group (3.2 ± 0.71 vs. 4.9 ± 1.51 ng/mL, p < 0.001). Multivariate regression analysis showed that the adropin level was the independent predictor of late saphenous vein graft occlusion. Conclusions: Adropin levels are lower in patients with late saphenous vein graft occlusion and these reduced adropin levels, together with other factors, may lead to saphenous vein graft occlusion. Larger and prospective studies are needed to determine if adropin plays a role in the pathogenesis of SVGD.

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Letter: Potential Predictors of Saphenous Vein Graft Disease After Coronary Artery Bypass Operations

Angiology ◽

10.1177/00033197211065559 ◽

2022 ◽

pp. 000331972110655

Author(s):

Senol Yavuz ◽

Mesut Engin ◽

Elif Yazgan ◽

Omer Furkan Demir ◽

Tamer Turk

Keyword(s):

Coronary Artery ◽

Coronary Artery Bypass ◽

Saphenous Vein ◽

Vein Graft ◽

Saphenous Vein Graft ◽

Artery Bypass ◽

Vein Graft Disease ◽

Graft Disease ◽

Saphenous Vein Graft Disease

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Management of Saphenous Vein Graft Disease in Patients with Prior Coronary Artery Bypass Surgery

Current Treatment Options in Cardiovascular Medicine ◽

10.1007/s11936-019-0714-7 ◽

2019 ◽

Vol 21 (2) ◽

Cited By ~ 4

Author(s):

Neda Dianati Maleki ◽

Arash Ehteshami Afshar ◽

Puja B. Parikh

Keyword(s):

Coronary Artery ◽

Saphenous Vein ◽

Vein Graft ◽

Coronary Artery Bypass Surgery ◽

Bypass Surgery ◽

Saphenous Vein Graft ◽

Artery Bypass ◽

Vein Graft Disease ◽

Graft Disease ◽

Saphenous Vein Graft Disease

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Immediate and One-Year Outcome of Percutaneous Intervention of Saphenous Vein Graft Disease With Paclitaxel-Eluting Stents

The American Journal of Cardiology ◽

10.1016/j.amjcard.2005.03.084 ◽

2005 ◽

Vol 96 (3) ◽

pp. 395-398 ◽

Cited By ~ 21

Author(s):

Keiichi Tsuchida ◽

Andrew T.L. Ong ◽

Jiro Aoki ◽

Carlos A.G. van Mieghem ◽

Gastón A. Rodriguez-Granillo ◽

...

Keyword(s):

Saphenous Vein ◽

Vein Graft ◽

Saphenous Vein Graft ◽

Percutaneous Intervention ◽

Vein Graft Disease ◽

One Year ◽

Graft Disease ◽

Saphenous Vein Graft Disease

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The roles of CHA2DS2-VASc score and blood inflammatory parameters in predicting the patency of saphenous vein grafts in patients with coronary artery bypass graft surgery

Medical Science and Discovery ◽

10.36472/msd.v8i10.617 ◽

2021 ◽

Vol 8 (10) ◽

pp. 601-607

Author(s):

Cihan Aydın ◽

Mustafa Abanoz

Keyword(s):

Coronary Artery ◽

Saphenous Vein ◽

Vein Graft ◽

Saphenous Vein Graft ◽

Bypass Graft ◽

Vein Graft Disease ◽

Group 2 ◽

Graft Disease ◽

Saphenous Vein Graft Disease ◽

Group 1

Objective: Coronary artery bypass graft (CABG) surgery is a common treatment method in which saphenous vein grafts (SVG) and arterial grafts are used together in severe coronary artery disease. The CHA2DS2-VASc score is used to predict thromboembolic events in nonvalvular atrial fibrillation as well as to predict prognosis in cardiovascular events. In this study, we planned to research the relation between CHA2DS2-VASc score and postoperative SVG patency rates in patients undergoing CABG. Materials and Methods: One hundred seventeen patients with angina after CABG surgery who underwent coronary angiography were analyzed retrospectively. Stenosis of 50% or more in at least one saphenous vein graft was accepted as saphenous vein graft disease (SVGD). We compared these patients in two groups concerning the presence of 50% or more stenosis in the SVG. These two groups were; Group 1 (n = 66); with saphenous vein graft disease, Group 2 (n = 51) without saphenous vein graft disease, respectively. Results: A total of 117 patients participating in the study. Sixty-six patients in group 1 had SVGD (Mean age: 68,13±8,22, 60,6% male). Fifty-one patients in group 2 did not have SVGD (Mean age: 66,92±9,44, 72,5% male ). The mean CHA2DS2-VASc score was significantly higher in group 1 compared to group 2. [5 (2-7) vs. 2 (1-7), respectively, P<0,001]. As a result of multivariate analysis, CHA2DS2-VASc score (OR: 5,263, CI 95%: 2,176- 12,728, P<0.001) and SII (OR: 1,236, CI 95%: 1,120-2,955, P=0.007) were determined as independent predictors for predicting SVGD Conclusion: In the light of the results we have found, the CHA2DS2-VASc score and SII, which are easy to calculate in daily practice, can help us in predicting SVGD.

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