scholarly journals History of the Use of Nitroxides (Aminoxyl Radicals) in Biochemistry: Past, Present and Future of Spin Label and Probe Method

10.5772/45779 ◽  
2012 ◽  
Author(s):  
Lawrence J.
Keyword(s):  
Spin Label ◽  
Probe Method ◽  
History Of ◽  
Aminoxyl Radicals

Synthesis of a Dihydroxy-Substituted Aminoxyl Spin Label and its Crown Ether and Cyclic Diester Derivatives

1993 ◽  
Vol 48 (4) ◽  
pp. 505-510 ◽  
Author(s):  
Yong-Kang Zhang ◽  
De-Kang Shen
Keyword(s):  
Crown Ether ◽  
Intramolecular Cyclization ◽  
Spin Label ◽  
Cyclic Ether ◽  
Synthetic Approach ◽  
Aminoxyl Radicals

A novel dihydroxy-substituted aminoxyl spin label, 4-hydroxy-3-(3'-hydroxypropyl)-2,2,6,6-tetramethylpiperidine-1-oxy (5), has been prepared. From this aminoxyl radical, a spin-labeled crown ether, 16,16,18,18-tetramethyl-2,5,8,11-tetraoxa-17-azabicyclo[ 13,4,0]-nonadecane-17-oxy (12), and a spin-labeled cyclic diester, 16,16,18,18-tetramethyl-3,10-dioxo-2,5,8,11-tetraoxa-17-azabicyclo[13,4,o]nonadecane-17-oxy (13), have been acquired. Other four new stable aminoxyl radicals 8,9,10, and 11 have also been obtained within the synthetic approach. It has been demonstrated that the cyclic ether compound (7) is generated by the reduction of its corresponding lactone which is sidely derived from the oxo-reduced species of 3 by intramolecular cyclization.

ENDOR DETERMINATION OF PROTON HYPERFINE SPLITTING CONSTANTS OF AMINOXYL RADICALS FREQUENTLY USED IN SPIN-PROBE-SPIN-LABEL METHOD

1984 ◽  
Vol 13 (1) ◽  
pp. 83-86 ◽  
Author(s):  
Yashige Kotake ◽  
Keiji Kuwata
Keyword(s):  
Spin Label ◽  
Hyperfine Splitting ◽  
Spin Probe ◽  
Label Method ◽  
Probe Spin ◽  
Aminoxyl Radicals
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