scholarly journals Evaluation of Cyclosporine and Tacrolimus Dose Changes During Post-transplantation Period and Their Association with Endomyocardial Biopsy Grading

2021 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Kambiz Mozaffari ◽  
Ahmad Amin ◽  
Mohammad Ahangarani Farahani ◽  
Nasim Naderi ◽  
Sepideh Taghavi ◽  
...  
Keyword(s):  
Endomyocardial Biopsy ◽  
Immunosuppressive Drugs ◽  
Tacrolimus Concentration ◽  
Cardiac Transplant ◽  
Post Transplantation ◽  
Potential Predictor ◽  
Transplant Patients ◽  
Reverse Relationship ◽  
Tacrolimus Dose

Background: Changes in the dosage of immunosuppressive drugs following organ transplantation, especially the heart, can be a potential predictor of long-term post-transplant outcomes. It may also be related to the degree of histopathological involvement of endomyocardium. Objectives: We aimed to evaluate cyclosporine and tacrolimus dose changes during post-transplantation biopsies and their association with endomyocardial biopsy grades. Methods: This retrospective study was performed on 100 cardiac transplant patients who underwent endomyocardial biopsies to assess graft stability. In the present study, the patients were divided into two groups receiving cyclosporine (13 cases) and tacrolimus (87 cases). The data was collected by reviewing the recorded files. Results: Regarding the administration of cyclosporine, at different times after biopsy, there was no significant relationship between the plasma level of the drug and the grade of biopsy. Concerning tacrolimus, there was a significant reverse association between serum concentration and biopsy grade at the first biopsy after transplantation (about one month after transplantation), although this relationship was not observed in the subsequent steps of biopsy. Also, the Quilty effect frequency was not significantly associated with biopsy grade in different biopsies for both drugs. Conclusions: There is a lack of association between endocardial biopsy grade in the heart and the serum level of cyclosporine after transplantation. However there is a significant reverse relationship between endomyocardial biopsy grade and serum Tacrolimus concentration in the first weeks after transplantation and thus monitoring serum Tacrolimus after transplantation may play an important role in predicting acute rejection.

scholarly journals Serum Creatine Kinase Kinetics after Endomyocardial Biopsy in Cardiac Transplant Patients

1997 ◽  
Vol 162 (1) ◽  
pp. 51-54
Author(s):  
Timothy R. Malinowski ◽  
Armistead L. Wellford ◽  
Nancy Khan ◽  
Bernard J. Rubal
Keyword(s):  
Creatine Kinase ◽  
Endomyocardial Biopsy ◽  
Serum Creatine Kinase ◽  
Cardiac Transplant ◽  
Transplant Patients

Long-term follow-up of cardiac transplant patients

1970 ◽  
Vol 25 (1) ◽  
pp. 88-89
Author(s):  
David A. Clark ◽  
Edward B. Stinson ◽  
John S. Schroeder ◽  
Norman E. Shumway ◽  
Donald C. Harrison
Keyword(s):  
Cardiac Transplant ◽  
Transplant Patients ◽  
Long Term Follow Up

Prognostic Significance of Heart Rate and its Long-term Trend in Cardiac Transplant Patients

2015 ◽  
Vol 68 (11) ◽  
pp. 943-950 ◽  
Author(s):  
Eduardo Barge-Caballero ◽  
Jesús Jiménez-López ◽  
Sergio Chávez-Leal ◽  
Gonzalo Barge-Caballero ◽  
María Jesús Paniagua-Martin ◽  
...  
Keyword(s):  
Heart Rate ◽  
Prognostic Significance ◽  
Cardiac Transplant ◽  
Term Trend ◽  
Transplant Patients ◽  
Long Term Trend

Eprosartan in the Primary Prevention of Cardiac Allograft Vascular Disease: A Double-Blind Prospectively Randomized Study using Intravascular Ultrasound

2008 ◽  
Vol 36 (5) ◽  
pp. 1022-1031 ◽  
Author(s):  
K Pethig ◽  
B Hornig ◽  
C Bara ◽  
B Schieffer ◽  
A Haverich ◽  
...  
Keyword(s):  
Randomized Study ◽  
Cardiac Allograft ◽  
Post Transplantation ◽  
Double Blind ◽  
Once Daily ◽  
Transplant Patients ◽  
Flow Reserve ◽  
Vessel Volume ◽  
Preventive Role

The angiotensin blocker (ARB) eprosartan (600 mg once daily) and the calcium antagonist diltiazem (90 mg twice daily) were studied in a 24-month prospective, randomized, double-blind trial involving 53 heart transplant patients. The study compared their effects on the development of post-transplant cardiac allograft vasculopathy, a condition that frequently impairs long-term post-transplantation survival and where angiotensin blockers might be expected to play a preventive role. From baseline to month 12, the mean plaque volume increased by 7.7 mm3 for eprosartan-treated patients and by 34.4 mm3 for diltiazem-treated patients, but the eprosartan-related trend for reduced myointimal hyperplasia was not statistically significant. The trend in favour of eprosartan for secondary parameters (mean intimal index, vessel volume, lumen volume and coronary flow reserve) also failed to reach significance. The lack of effect might be due to a lower than planned sample size and observation periods due to recruitment difficulties. A larger study is required to confirm these preliminary findings.

scholarly journals Long-Term Impact of Different Immunosuppressive Drugs on QT and PR Intervals in Renal Transplant Patients

2014 ◽  
Vol 20 (5) ◽  
pp. 426-432 ◽  
Author(s):  
Baris Ikitimur ◽  
Kahraman Cosansu ◽  
Bilgehan Karadag ◽  
Huseyin Altug Cakmak ◽  
Burcak Kilickiran Avci ◽  
...  
Keyword(s):  
Renal Transplant ◽  
Immunosuppressive Drugs ◽  
Transplant Patients ◽  
Renal Transplant Patients ◽  
Long Term Impact

scholarly journals Long-term hemodynamic follow-up of cardiac transplant patients treated with cyclosporine and prednisone.

Circulation ◽  
1985 ◽  
Vol 71 (3) ◽  
pp. 487-494 ◽  
Author(s):  
M L Greenberg ◽  
B F Uretsky ◽  
P S Reddy ◽  
R L Bernstein ◽  
B P Griffith ◽  
...  
Keyword(s):  
Cardiac Transplant ◽  
Transplant Patients

Development of Proteinuria After Switch to Sirolimus-Based Immunosuppression in Long-Term Cardiac Transplant Patients

2008 ◽  
Vol 8 (4) ◽  
pp. 854-861 ◽  
Author(s):  
A. Z. Aliabadi ◽  
E. Pohanka ◽  
G. Seebacher ◽  
D. Dunkler ◽  
D. Kammerstätter ◽  
...  
Keyword(s):  
Cardiac Transplant ◽  
Transplant Patients

scholarly journals Quantitative cardiac magnetic resonance T2 imaging offers ability to non-invasively predict acute allograft rejection in children

2020 ◽  
Vol 30 (6) ◽  
pp. 852-859
Author(s):  
Neeta Sethi ◽  
Ashish Doshi ◽  
Tina Doshi ◽  
Russell Cross ◽  
Ileen Cronin ◽  
...  
Keyword(s):  
Cardiac Magnetic Resonance ◽  
Magnetic Resonance ◽  
Acute Rejection ◽  
Endomyocardial Biopsy ◽  
Allograft Rejection ◽  
T2 Mapping ◽  
Left Ventricular ◽  
Cardiac Transplant ◽  
Acute Allograft Rejection ◽  
Transplant Patients

AbstractBackground:Monitoring for acute allograft rejection improves outcomes after cardiac transplantation. Endomyocardial biopsy is the gold standard test defining rejection, but carries risk and has limitations. Cardiac magnetic resonance T2 mapping may be able to predict rejection in adults, but has not been studied in children. Our aim was to evaluate T2 mapping in identifying paediatric cardiac transplant patients with acute rejection.Methods:Eleven paediatric transplant patients presenting 18 times were prospectively enrolled for non-contrast cardiac magnetic resonance at 1.5 T followed by endomyocardial biopsy. Imaging included volumetry, flow, and T2 mapping. Regions of interest were manually selected on the T2 maps using the middle-third technique in the left ventricular septal and lateral wall in a short-axis and four-chamber slice. Mean and maximum T2 values were compared with Student’s t-tests analysis.Results:Five cases of acute rejection were identified in three patients, including two cases of grade 2R on biopsy and three cases of negative biopsy treated for clinical symptoms attributed to rejection (new arrhythmia, decreased exercise capacity). A monotonic trend between increasing T2 values and higher biopsy grades was observed: grade 0R T2 53.4 ± 3 ms, grade 1R T2 54.5 ms ± 3 ms, grade 2R T2 61.3 ± 1 ms. The five rejection cases had significantly higher mean T2 values compared to cases without rejection (58.3 ± 4 ms versus 53 ± 2 ms, p = 0.001).Conclusions:Cardiac magnetic resonance with quantitative T2 mapping may offer a non-invasive method for screening paediatric cardiac transplant patients for acute allograft rejection. More data are needed to understand the relationship between T2 and rejection in children.

Sign in / Sign up

Export Citation Format

Share Document