Clear Cell Adenocarcinoma of the Urinary Bladder: A Short Review

2009 ◽  
Vol 133 (6) ◽  
pp. 987-991 ◽  
Author(s):  
Adebowale J. Adeniran ◽  
Pheroze Tamboli
Keyword(s):  
Urinary Bladder ◽  
Patient Outcomes ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Short Review ◽  
Ca 125 ◽  
Clear Cell Adenocarcinoma ◽  
Gross Hematuria ◽  
Nephrogenic Adenoma ◽  
Clear Cytoplasm

Abstract In this short review, we discuss clear cell adenocarcinoma of the urinary bladder, a rare tumor that primarily affects women. The histogenesis of this neoplasm is uncertain; in some tumors the clinicopathologic and histologic features are suggestive of a müllerian origin. Clear cell adenocarcinoma consists of cells with abundant clear cytoplasm, arranged in solid, glandular, or tubulocystic patterns. These tumors are positive for pancytokeratin, cytokeratin 7, and CA 125 immunohistochemical stains. Patients typically present with gross hematuria, dysuria, and discharge. The natural history is poorly understood and patient outcomes remain unclear. Currently, surgery is the treatment of choice. Nephrogenic adenoma is the most important differential diagnostic consideration, followed by metastatic clear cell carcinoma.

scholarly journals Primary Clear Cell Carcinoma of the Urinary Bladder

2014 ◽  
Vol 2014 ◽  
pp. 1-15 ◽  
Author(s):  
Anthony Kodzo-Grey Venyo
Keyword(s):  
Urinary Bladder ◽  
Cell Carcinoma ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Primary Tumour ◽  
B Cell Lymphoma ◽  
Ca 125 ◽  
Eosinophilic Cytoplasm ◽  
Clear Cytoplasm ◽  
Immunohistochemistry Stain

Primary clear cell carcinoma of the urinary bladder (PCCUB) is rare. Literature review has revealed 47 cases of PCCUB which commonly affects women. The histogenesis of PCCUB is not certain and Müllerian origin and urotheilal origin have been postulated. The microscopic characteristics of PCCUB include cells with abundant clear cytoplasm, arranged in a solid, glandular, tubulocystic, or papillary pattern. The cells may be flat or cuboidal with abundant clear eosinophilic cytoplasm. Hobnailing may be evident. PCCUB, on immunohistochemistry, stain positively with pan-cytokeratin, cytokeratin 7, and CA 125. PCCUB may manifest with visible haematuria, lower urinary tract symptoms, and discharge. There is no consensus opinion regarding the best treatment option for PCCUBs and patient outcomes are not very clear. Surgery has been the adopted treatment of choice. Differential diagnoses of PCCUB include nephrogenic metaplasia, urothelial carcinoma with clear cell cytoplasm, diffuse large B-cell lymphoma, and metastatic clear cell carcinoma with the primary originating elsewhere. Conclusions. A thorough radiological imaging assessment is required in cases of PCCUB to exclude a primary tumour elsewhere. Urologists and oncologists should report cases of PCCUB they encounter and should enter them into a multicentric trial to ascertain the best management option.

Clear Cell Adenocarcinoma of Urinary Bladder and Urethra: Another Urinary Tract Lesion Immunoreactive for P504S

2008 ◽  
Vol 132 (9) ◽  
pp. 1417-1422 ◽  
Author(s):  
Katherine Sun ◽  
Youming Huan ◽  
Pamela D. Unger
Keyword(s):  
Urinary Tract ◽  
Urinary Bladder ◽  
Cell Carcinoma ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Female Genital Tract ◽  
Papillary Renal Cell Carcinoma ◽  
Ca 125 ◽  
Clear Cell Adenocarcinoma

Abstract Context.—Clear cell carcinoma of the urinary bladder/ urethra is a rare tumor histologically resembling the neoplasms in the female genital tract. Adequate characterization of this tumor has been hampered by its rarity. α-Methylacyl-CoA racemase (AMACR)/P504S has been reported to be positive in prostatic adenocarcinoma, papillary renal cell carcinoma, and gastrointestinal neoplasmas; however, it has never been studied in clear cell carcinoma of the lower urinary tract. Objective.—To investigate the immunohistochemical staining profile in 4 primary clear cell carcinomas of the urinary tract, including P504S, which has not been previously evaluated in these tumors. Design.—Four cases of clear cell adenocarcinoma were retrieved from our archives: 2 cases from the urinary bladder (one each from a man and a woman) and 2 cases from the urethra (both from women, 1 in a diverticulum). Immunohistochemistry performed on the cases were P504S, K903, cytokeratin (CK) 7, CK20, CA 125, and p63. Results.—We found that clear cell carcinomas had a distinct immunoreactive profile: strongly positive for P504S, K903, and CK7, and negative for p63. Two cases were also positive for CA 125 and CK20. Conclusion.—The immunohistochemical profile of clear cell carcinomas shares some similarity to conventional urothelial carcinoma; however, it deviates from those tumors in being positive for P504S and negative for p63. This staining profile may suggest a nonurothelial origin for these tumors, may serve as a useful tool in the differential diagnosis of this tumor, and may reflect its etiology. Because similar expression of P504S is also seen in nephrogenic adenomas, this marker should not be used to differentiate nephrogenic adenomas from clear cell adenocarcinomas.

Clear cell adenocarcinoma and nephrogenic adenoma of the urethra and urinary bladder: A histopathologic and immunohistochemical comparison

1998 ◽  
Vol 29 (12) ◽  
pp. 1451-1456 ◽  
Author(s):  
Michael Z Gilcrease ◽  
Ruby Delgado ◽  
Frank Vuitch ◽  
Jorge Albores-Saavedra
Keyword(s):  
Urinary Bladder ◽  
Clear Cell ◽  
Clear Cell Adenocarcinoma ◽  
Nephrogenic Adenoma

scholarly journals Nephrogenic Adenoma of the Urinary Bladder: A Review of the Literature

2015 ◽  
Vol 2015 ◽  
pp. 1-15 ◽  
Author(s):  
Anthony Kodzo-Grey Venyo
Keyword(s):  
Urinary Bladder ◽  
Urothelial Carcinoma ◽  
Dna Analysis ◽  
Single Layer ◽  
Clear Cell Adenocarcinoma ◽  
Positive Staining ◽  
Nephrogenic Adenoma ◽  
Intravesical Bcg ◽  
Clear Cytoplasm ◽  
Rare Lesion

Background. Nephrogenic adenoma of the urinary bladder (NAUB) is a rare lesion associated with nonspecific symptoms and could inadvertently be misdiagnosed. Aim. To review the literature. Methods. Various internet search engines were used. Results. NAUB is a benign tubular and papillary lesion of the bladder, is more common in men and adults, and has been associated with chronic inflammation/irritation, previous bladder surgery, diverticula, renal transplantation, and intravesical BCG; recurrences and malignant transformations have been reported. Differential diagnoses include clear cell adenocarcinoma, endocervicosis, papillary urothelial carcinoma, prostatic adenocarcinoma of bladder, and nested variant of urothelial carcinoma; most NAUBs have both surface papillary and submucosal tubular components; both the papillae and tubules tend to be lined by a single layer of mitotically inactive bland cells which have pale to clear cytoplasm. Diagnosis may be established by using immunohistochemistry (positive staining with racemase; PAX2; keratins stain positive with fibromyxoid variant), electron microscopy, DNA analysis, and cytological studies. Treatment. Endoscopic resection is the treatment but recurrences including sporadic malignant transformation have been reported. Conclusions. There is no consensus on best treatment. A multicentre study is required to identify the treatment that would reduce the recurrence rate, taking into consideration that intravesical BCG is associated with NAUB.

Clear cell carcinoma of Mullerian origin in the urinary bladder: A rare entity

2021 ◽  
pp. 205141582098766
Author(s):  
Harshit Garg ◽  
Brusabhanu Nayak ◽  
Tripti Nakra ◽  
Prabhjot Singh ◽  
Seema Kaushal
Keyword(s):  
Urinary Bladder ◽  
Cell Carcinoma ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Total Abdominal Hysterectomy ◽  
Abdominal Hysterectomy ◽  
Rare Entity ◽  
Level Of Evidence ◽  
History Of ◽  
Carcinoma Of The Bladder

Mullerian neoplasms of the urinary system are rare but complex tumor-like lesions. The identification of the Mullerian neoplasm is crucial for patient management owing to its etiology, natural history, and prognosis. We present a case of a 42-year-old female with a history of three lower segment cesarean sections presenting with complaints of dysmenorrhea and suprapubic pain with no history of hematuria or any urinary symptoms. Magnetic resonance imaging revealed a 2 cm×2 cm exophytic lesion suspicious of being either a bladder lesion or an endometrial lesion infiltrating the urinary bladder. Cystoscopy and transurethral biopsy of this suspicious bladder tumor revealed a malignant tumor with papillary and tubulocystic architecture. Based on the overall histomorphological and immunohistochemical features, a diagnosis of clear cell carcinoma of Mullerian origin was made, and the patient underwent a total abdominal hysterectomy with bilateral salpingo-oophorectomy and partial cystectomy. The patient was kept on regular surveillance and showed no signs of recurrence at the one-year follow-up. Clear cell carcinoma of the bladder of Mullerian origin is a rare entity and is established on histopathology. Prompt diagnosis and a multidisciplinary approach are indispensable for management. Level of evidence: Level 4.

A Case Report of Pediatric Clear Cell Carcinoma of the Urinary Bladder Associated With Polyomavirus

2018 ◽  
pp. 1 ◽  
Author(s):  
Atif Saleem ◽  
Ryanne A. Brown ◽  
John P. T. Higgins ◽  
Megan L. Troxell ◽  
Christian A. Kunder ◽  
...  
Keyword(s):  
Case Report ◽  
Urinary Bladder ◽  
Cell Carcinoma ◽  
Clear Cell ◽  
Clear Cell Carcinoma

Clear cell adenocarcinoma of the urinary bladder inducing acute renal failure

2002 ◽  
Vol 9 (8) ◽  
pp. 467-469 ◽  
Author(s):  
Yoh Matsuoka ◽  
Tatsuya Machida ◽  
Kaoru Oka ◽  
Kazuhiro Ishizaka
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Urinary Bladder ◽  
Clear Cell ◽  
Clear Cell Adenocarcinoma

scholarly journals Primary clear cell carcinoma of urinary bladder: A case report

2018 ◽  
Vol 16 ◽  
pp. 41-43 ◽  
Author(s):  
Mahmoudreza Moradi ◽  
Shahram Shojaei ◽  
Kaveh Kaseb ◽  
Haress Rezaee
Keyword(s):  
Case Report ◽  
Urinary Bladder ◽  
Cell Carcinoma ◽  
Clear Cell ◽  
Clear Cell Carcinoma

scholarly journals Clear Cell Adenocarcinoma of the Ureter Similar to Clear Cell Renal Cell Carcinoma Histology

2021 ◽  
Vol 2021 ◽  
pp. 1-4
Author(s):  
Kazuhiro Watanabe ◽  
Go Hasegawa ◽  
Yohei Ikeda ◽  
Noboru Hara ◽  
Tsutomu Nishiyama
Keyword(s):  
Renal Cell Carcinoma ◽  
Urothelial Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Clear Cell Adenocarcinoma ◽  
Cell Renal Cell Carcinoma ◽  
Carcinoma Lesion

A 70-year-old woman was referred to our hospital with gross hematuria and diagnosed with right invasive ureteral cancer and bladder urothelial carcinoma in situ. Intravesical BCG therapy and neoadjuvant chemotherapy with carboplatin and gemcitabine were performed at the same time. Subsequently, laparoscopic right nephroureterectomy was performed. Urothelial carcinoma in situ persisted; however, most of the tumor was clear cell carcinoma. The clear cell carcinoma lesion had clear cytoplasm with round nuclei and visible nucleoli in an insular arrangement as is the case with clear cell renal cell carcinoma. No transitional lesion between clear cell adenocarcinoma and urothelial carcinoma was presented. The clear cell carcinoma lesion was GATA3 negative and HNF4α positive; however, the urothelial cancer lesion was GATA3 positive and HNF4α negative. Clear cell carcinoma was diagnosed as clear cell adenocarcinoma similar to clear cell renal cell carcinoma histology.

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