renal cell
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2022 ◽  
Vol 17 (3) ◽  
pp. 439-441
Marco Enoch Lee ◽  
Veronica Chi Ken Wong ◽  
Chuong Bui ◽  
Robert Mansberg

2022 ◽  
Vol 17 (3) ◽  
pp. 619-622
Masashi Endo ◽  
Hiroyuki Fujii ◽  
Akifumi Fujita ◽  
Tatsuya Takayama ◽  
Daisuke Matsubara ◽  

Oral Oncology ◽  
2022 ◽  
Vol 125 ◽  
pp. 105705
Satish Maharaj ◽  
Karan Seegobin ◽  
Kristina Wakeman ◽  
Simone Chang ◽  
Kevin Potts ◽  

2022 ◽  
Vol 9 (1) ◽  
Yasuto Yagi ◽  
Naoko Abeto ◽  
Junichi Shiraishi ◽  
Chieko Miyata ◽  
Satomi Inoue ◽  

AbstractHereditary leiomyomatosis and renal cell carcinoma caused by loss-of-function germline variants of the FH gene can develop into aggressive renal cell carcinoma (RCC). We report the case of a 27-year-old man who died of RCC. Genetic testing revealed a novel pathogenic variant of FH, NM_000143.3:c.1013_1014del (p.Ile338Serfs*3), that was also identified in healthy siblings. Identification of genetic causes in the proband helped us to provide relatives with precise genetic counseling and appropriate surveillance programs.

2022 ◽  
Vol Publish Ahead of Print ◽  
Ajit Paintal ◽  
Melissa Y. Tjota ◽  
Peng Wang ◽  
Carrie Fitzpatrick ◽  
Pankhuri Wanjari ◽  

2022 ◽  
Vol 8 ◽  
Fang-Yu Yen ◽  
Wen-Kuei Chang ◽  
Shih-Pin Lin ◽  
Tzu-Ping Lin ◽  
Kuang-Yi Chang

Whether epidural anesthesia and analgesia (EA) is beneficial for postoperative cancer outcomes remains controversial and we conducted this historical cohort study to evaluate the association between EA and long-term outcomes following surgery for renal cell carcinoma (RCC). We collected patients receiving RCC surgery from 2011 to 2017 and followed up them until February 2020. Patient attributes, surgical factors and pathological features were gathered through electronic medical chart review. The association between EA and recurrence-free and overall survival after surgery was evaluated using Cox regression models with inverse probability of treatment weighting (IPTW) to balance the observed covariates. The median follow-up time for the 725 included patients was 50 months (interquartile range: 25.3–66.5) and 145 of them (20%) received perioperative EA. We demonstrated EA use was associated with better recurrence-free survival [IPTW adjusted hazard ratio (HR): 0.64, 95% confidence interval (CI): 0.49–0.83, p < 0.001] and overall survival [IPTW adjusted HR: 0.66, 95% CI: 0.49–0.89, p = 0.006] in patients receiving surgical resection for RCC. More prospective studies are needed to verify this connection between EA and superior cancer outcomes after RCC surgery.

2022 ◽  
Vol 6 (1) ◽  
Kenta Takayasu ◽  
Koei Muguruma ◽  
Hidefumi Kinoshita

Immune checkpoint inhibitors, which promote or suppress the anti-tumor immune response, are becoming the mainstay of cancer treatment. In 2018, CheckMate 214 study showed a higher response rate with ipilimumab and nivolumab combination therapy compared to conventional therapy for advanced renal cell carcinoma. We report a case of complete response and durable response for two years to ipilimumab and nivolumab combination therapy in a patient with postoperative renal cancer recurrence that caused immune-related adverse events such as interstitial pneumonia and hepatotoxicity.

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