Small Cell Carcinoma of the Urinary Bladder: A Rare, Aggressive Neuroendocrine Malignancy

2012 ◽  
Vol 136 (11) ◽  
pp. 1451-1459 ◽  
Author(s):  
Xiangrong Zhao ◽  
Ethan A. Flynn
Keyword(s):  
Urinary Bladder ◽  
Urothelial Carcinoma ◽  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Treatment Algorithm ◽  
Small Cell ◽  
Fatal Disease ◽  
Presenting Symptoms ◽  
Immunohistochemical Markers ◽  
Definite Treatment

Small cell carcinoma of the urinary bladder is a rare, often fatal, disease. Its presenting symptoms and gross morphology are similar to those of conventional urothelial carcinoma, whereas its prognosis is much poorer with frequent metastasis. Small cell carcinoma of the urinary bladder shares similar histology with its counterparts in other organs; however, its immunoreactivity to conventional neuroendocrine markers is low. Its diagnosis is thus considered permissible on morphologic grounds alone. Multimodal treatments are often employed, although no definite treatment algorithm has been established. For this extremely aggressive malignancy with an as-yet inconclusive etiology, further studies are needed to clarify its molecular pathogenesis to serve as a basis for diagnostic markers and therapeutic targets. The clinical, morphologic, immunoreactive, molecular, and therapeutic features of bladder small cell carcinoma are reviewed, including a detailed discussion on the utility of immunohistochemical markers.

scholarly journals Molecular Genetic Evidence for a Common Clonal Origin of Urinary Bladder Small Cell Carcinoma and Coexisting Urothelial Carcinoma

2005 ◽  
Vol 166 (5) ◽  
pp. 1533-1539 ◽  
Author(s):  
Liang Cheng ◽  
Timothy D. Jones ◽  
Ryan P. McCarthy ◽  
John N. Eble ◽  
Mingsheng Wang ◽  
...  
Keyword(s):  
Urinary Bladder ◽  
Urothelial Carcinoma ◽  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Molecular Genetic ◽  
Small Cell ◽  
Genetic Evidence ◽  
Clonal Origin ◽  
Molecular Genetic Evidence

Metachronous primary urothelial carcinoma following small cell carcinoma of the urinary bladder

2014 ◽  
Vol 87 (1-2) ◽  
pp. 96-98
Author(s):  
Henry H. I. Yao ◽  
Kevin Chu ◽  
Christopher Hallot ◽  
Jonathan Lewin
Keyword(s):  
Urinary Bladder ◽  
Urothelial Carcinoma ◽  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Small Cell

Distinction of High-Grade Neuroendocrine Carcinoma/Small Cell Carcinoma From Conventional Urothelial Carcinoma of Urinary Bladder

2011 ◽  
Vol 19 (5) ◽  
pp. 395-399 ◽  
Author(s):  
Sherry Thompson ◽  
Maureen Cioffi-Lavina ◽  
Jennifer Chapman-Fredricks ◽  
Carmen Gomez-Fernandez ◽  
Gustavo Fernandez-Castro ◽  
...  
Keyword(s):  
Urinary Bladder ◽  
Urothelial Carcinoma ◽  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Neuroendocrine Carcinoma ◽  
Small Cell ◽  
High Grade

scholarly journals Transdifferentiation of Small Cell Carcinoma of the Urinary Bladder from Urothelial Carcinoma after Transurethral Resection of a Bladder Tumor, Intravesical Bacillus Calmette-Guerin Instillation, and Chemotherapy: A Case Report

2016 ◽  
Vol 9 (3) ◽  
pp. 786-791 ◽  
Author(s):  
Kento Morozumi ◽  
Shunichi Namiki ◽  
Takashi Kudo ◽  
Masataka  Aizawa ◽  
Naomasa  Ioritani ◽  
...  
Keyword(s):  
Case Report ◽  
Urinary Bladder ◽  
Urothelial Carcinoma ◽  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Transurethral Resection ◽  
Bladder Tumor ◽  
Small Cell ◽  
Pathological Examination ◽  
Bacillus Calmette Guerin

A 73-year-old male underwent transurethral resection of a bladder tumor in August 2010 and April 2011. Pathological examination revealed urothelial carcinoma. After the surgery, chemotherapy and intravesical Bacillus Calmette-Guerin instillation were performed. In September 2014, he once again underwent transurethral resection of the bladder tumor for recurrence, and was again diagnosed with urothelial carcinoma, pT2, by pathological examination. After neoadjuvant chemotherapy, radical cystectomy for tumor recurrence was performed. Pathological examination at this time revealed small cell carcinoma, pT3N0. It is rare for urothelial carcinoma to change to small cell carcinoma, and the mechanism and cause of this change are still unknown. In this case report, we discuss what causes small cell carcinoma of the urinary bladder and review the literature regarding its origin.

scholarly journals Metastatic Small Cell Carcinoma of the Urinary Bladder That Recurred in the Vagina 6 Years after Radical Cystectomy: A Case Report

2018 ◽  
Vol 2018 ◽  
pp. 1-5 ◽  
Author(s):  
Makoto Isono ◽  
Keiichi Ito ◽  
Shinsuke Hamada ◽  
Masahiro Takahashi ◽  
Hidenori Sasa ◽  
...  
Keyword(s):  
Urinary Bladder ◽  
Urothelial Carcinoma ◽  
Cell Carcinoma ◽  
Radical Cystectomy ◽  
Small Cell Carcinoma ◽  
Transurethral Resection ◽  
Small Cell ◽  
Pelvic Bone ◽  
High Grade ◽  
Surgical Specimen

Small cell carcinoma (SCC) of the urinary bladder is highly aggressive and portends a poor outcome. Herein, we report a patient with recurrent SCC of the urinary bladder who experienced an unusually long-term disease-free duration after radical cystectomy. The patient was a 60-year-old woman who had undergone transurethral resection followed by radical cystectomy for muscle-invasive bladder cancer (high-grade urothelial carcinoma with adenocarcinomatous differentiation) 6 years prior; the surgical specimen had a negative surgical margin. She was referred to our hospital because of continuous bleeding from her vagina. Magnetic resonance imaging showed a mass located at the anterior wall of her residual vagina, a biopsy of which confirmed a pathological diagnosis of adenocarcinoma. The vaginal tumor and a section of the sigmoid colon were resected en bloc and were pathologically diagnosed as adenocarcinoma and SCC. We reevaluated the initial transurethral resection specimen and found SCC with foci of adenocarcinoma concomitant with high-grade urothelial carcinoma. Local recurrence and metastasis at the pelvic bone occurred 4 months later; although radiation therapy was performed, she died of the progressive disease.

Small Cell Carcinoma of the Urinary Bladder. A Clinicopathologic Study of Five Cases

2003 ◽  
Vol 89 (3) ◽  
pp. 328-330 ◽  
Author(s):  
Ozkan Kanat ◽  
Turkkan Evrensel ◽  
Saduman Balaban Adim ◽  
Ismet Yavascaoglu ◽  
Ender Kurt ◽  
...  
Keyword(s):  
Urinary Bladder ◽  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Transitional Cell ◽  
Small Cell ◽  
Clinical Staging ◽  
Primary Therapy ◽  
Presenting Symptoms ◽  
Clinicopathologic Study ◽  
Carcinoma Of The Bladder

Aims and Background Small cell carcinoma of the bladder (SCCB) is a rare entity characterized clinically by an aggressive behavior with a high incidence of systemic metastases. We report the clinicopathologic findings of five cases. Methods We reviewed five consecutive patients with SCCB treated at our institute. In each case the following clinical data were recorded: age, sex, presenting symptoms, endoscopically determined location of the tumor, clinical staging, node involvement (if any), site of metastases (if any), treatment, follow-up and outcome. Results There were four male and one female patients, age range 42 to 68 years, mean 57.6 years. The clinical presentation was not different from conventional transitional cell carcinoma, with hematuria being the most frequent complaint (four cases). Microscopic examination revealed oat cells in three cases and an intermediate variant in one. At the time of diagnosis the tumors were staged as T3bN2M0, T2N2M0, T4N0M0, T3aN0M0, and T2N0M0. Primary therapy consisted of radical cystectomy alone (one case), transurethral resection (TUR) alone (one case), TUR with chemotherapy (two cases), or TUR with chemotherapy and radiotherapy (one case). Four patients died of progressive disease, with survival from the time of diagnosis ranging from 7 to 16 months (mean, 12.2 months). One patient died of myocardial infarction (unrelated to the primary disease) one month after diagnosis. Conclusion Our study indicates that primary small cell carcinoma of the urinary bladder is as aggressive as its pulmonary counterpart and the overall prognosis of this tumor is very poor.

Undifferentiated Small Cell Carcinoma of the Urinary Bladder

1992 ◽  
Vol 85 (2) ◽  
pp. 189-192 ◽  
Author(s):  
NORMAN A. GROSSL ◽  
ANTIMO G. CANDEL ◽  
HEIDI A. NORDBROCK ◽  
ANDREA C. GROSSL
Keyword(s):  
Urinary Bladder ◽  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Small Cell
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