Small-cell Carcinomas of the Urinary Bladder and Prostate: TERT Promoter Mutation Status Differentiates Sites of Malignancy and Provides Evidence of Common Clonality Between Small-cell Carcinoma of the Urinary Bladder and Urothelial Carcinoma

Small cell carcinoma of the urinary bladder is a rare, often fatal, disease. Its presenting symptoms and gross morphology are similar to those of conventional urothelial carcinoma, whereas its prognosis is much poorer with frequent metastasis. Small cell carcinoma of the urinary bladder shares similar histology with its counterparts in other organs; however, its immunoreactivity to conventional neuroendocrine markers is low. Its diagnosis is thus considered permissible on morphologic grounds alone. Multimodal treatments are often employed, although no definite treatment algorithm has been established. For this extremely aggressive malignancy with an as-yet inconclusive etiology, further studies are needed to clarify its molecular pathogenesis to serve as a basis for diagnostic markers and therapeutic targets. The clinical, morphologic, immunoreactive, molecular, and therapeutic features of bladder small cell carcinoma are reviewed, including a detailed discussion on the utility of immunohistochemical markers.

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Comparative study of TERT promoter mutation status within spatially, temporally and morphologically distinct components of urothelial carcinoma

Histopathology ◽

10.1111/his.13318 ◽

2017 ◽

Vol 72 (2) ◽

pp. 354-356 ◽

Cited By ~ 7

Author(s):

Noah A Brown ◽

Madelyn Lew ◽

Helmut C Weigelin ◽

Alon Z Weizer ◽

Jeffrey S Montgomery ◽

...

Keyword(s):

Comparative Study ◽

Urothelial Carcinoma ◽

Tert Promoter Mutation ◽

Promoter Mutation ◽

Mutation Status ◽

Tert Promoter

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What is small cell carcinoma of the urinary bladder? What are the biologic behaviors of this tumor and its relationship to the conventional urothelial carcinoma?

Questions in Daily Urologic Practice ◽

10.1007/978-4-431-72819-1_34 ◽

2009 ◽

pp. 181-184

Keyword(s):

Urinary Bladder ◽

Urothelial Carcinoma ◽

Cell Carcinoma ◽

Small Cell Carcinoma ◽

Small Cell

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Transdifferentiation of Small Cell Carcinoma of the Urinary Bladder from Urothelial Carcinoma after Transurethral Resection of a Bladder Tumor, Intravesical Bacillus Calmette-Guerin Instillation, and Chemotherapy: A Case Report

Case Reports in Oncology ◽

10.1159/000452945 ◽

2016 ◽

Vol 9 (3) ◽

pp. 786-791 ◽

Cited By ~ 2

Author(s):

Kento Morozumi ◽

Shunichi Namiki ◽

Takashi Kudo ◽

Masataka Aizawa ◽

Naomasa Ioritani ◽

...

Keyword(s):

Case Report ◽

Urinary Bladder ◽

Urothelial Carcinoma ◽

Cell Carcinoma ◽

Small Cell Carcinoma ◽

Transurethral Resection ◽

Bladder Tumor ◽

Small Cell ◽

Pathological Examination ◽

Bacillus Calmette Guerin

A 73-year-old male underwent transurethral resection of a bladder tumor in August 2010 and April 2011. Pathological examination revealed urothelial carcinoma. After the surgery, chemotherapy and intravesical Bacillus Calmette-Guerin instillation were performed. In September 2014, he once again underwent transurethral resection of the bladder tumor for recurrence, and was again diagnosed with urothelial carcinoma, pT2, by pathological examination. After neoadjuvant chemotherapy, radical cystectomy for tumor recurrence was performed. Pathological examination at this time revealed small cell carcinoma, pT3N0. It is rare for urothelial carcinoma to change to small cell carcinoma, and the mechanism and cause of this change are still unknown. In this case report, we discuss what causes small cell carcinoma of the urinary bladder and review the literature regarding its origin.

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Metastatic Small Cell Carcinoma of the Urinary Bladder That Recurred in the Vagina 6 Years after Radical Cystectomy: A Case Report

Case Reports in Urology ◽

10.1155/2018/3069294 ◽

2018 ◽

Vol 2018 ◽

pp. 1-5 ◽

Cited By ~ 1

Author(s):

Makoto Isono ◽

Keiichi Ito ◽

Shinsuke Hamada ◽

Masahiro Takahashi ◽

Hidenori Sasa ◽

...

Keyword(s):

Urinary Bladder ◽

Urothelial Carcinoma ◽

Cell Carcinoma ◽

Radical Cystectomy ◽

Small Cell Carcinoma ◽

Transurethral Resection ◽

Small Cell ◽

Pelvic Bone ◽

High Grade ◽

Surgical Specimen

Small cell carcinoma (SCC) of the urinary bladder is highly aggressive and portends a poor outcome. Herein, we report a patient with recurrent SCC of the urinary bladder who experienced an unusually long-term disease-free duration after radical cystectomy. The patient was a 60-year-old woman who had undergone transurethral resection followed by radical cystectomy for muscle-invasive bladder cancer (high-grade urothelial carcinoma with adenocarcinomatous differentiation) 6 years prior; the surgical specimen had a negative surgical margin. She was referred to our hospital because of continuous bleeding from her vagina. Magnetic resonance imaging showed a mass located at the anterior wall of her residual vagina, a biopsy of which confirmed a pathological diagnosis of adenocarcinoma. The vaginal tumor and a section of the sigmoid colon were resected en bloc and were pathologically diagnosed as adenocarcinoma and SCC. We reevaluated the initial transurethral resection specimen and found SCC with foci of adenocarcinoma concomitant with high-grade urothelial carcinoma. Local recurrence and metastasis at the pelvic bone occurred 4 months later; although radiation therapy was performed, she died of the progressive disease.

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