scholarly journals Partial exchange transfusion in a patient with homozygous sickle cell disease undergoing heart surgery with cardiopulmonary bypass: a case report

Medwave ◽  
2012 ◽  
Vol 12 (10) ◽  
pp. e5554-e5554
Author(s):  
Deyvis Cruz
Keyword(s):  
Case Report ◽  
Cardiopulmonary Bypass ◽  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Exchange Transfusion ◽  
Heart Surgery ◽  
Cell Disease ◽  
Homozygous Sickle Cell Disease

Cardiac Surgery and Sickle Cell Disease

2008 ◽  
Vol 16 (6) ◽  
pp. 479-482 ◽  
Author(s):  
Khaled E Al-Ebrahim
Keyword(s):  
Cardiac Surgery ◽  
Sickle Cell Disease ◽  
Surgical Technique ◽  
Sickle Cell ◽  
Exchange Transfusion ◽  
Heart Surgery ◽  
Open Heart Surgery ◽  
Open Heart ◽  
Cell Disease ◽  
Homozygous Sickle Cell Disease

Three patients with homozygous sickle cell disease underwent successful open heart surgery for multivalvular lesions. Details of the surgical technique and the necessary precautions are described. Exchange transfusion was implemented in all cases. Crucial issues in cardiac surgical management to avoid or at least minimize vasoocclusive crisis and associated complications are discussed.

scholarly journals Perioperative Endocarditis Management in a Patient with Homozygous Sickle Cell Disease

2019 ◽  
Vol 08 (01) ◽  
pp. e1-e4 ◽  
Author(s):  
Malgorzata Gozdzik ◽  
Sergio Mariotti ◽  
Michele Genoni ◽  
Alicja Zientara
Keyword(s):  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Heart Surgery ◽  
Open Heart Surgery ◽  
Cell Disease ◽  
Coagulase Negative Staphylococci ◽  
Right Heart ◽  
Double Valve Replacement ◽  
Increased Risk ◽  
Homozygous Sickle Cell Disease

Background Homozygous sickle cell disease (SCD) compounded with bacterial endocarditis makes open-heart surgery a multidisciplinary challenge. Case description A 45-year-old African male patient with homozygous SCD presented with right heart decompensation, tricuspid regurgitation, and endocarditis of the aortic valve. Blood coulters were positive for coagulase-negative staphylococci. An emergent double valve replacement was successfully performed involving a multidisciplinary team. Conclusion Homozygous SCD is associated with an increased risk of preoperative vaso-occlusive complications. Surgery with cardiopulmonary bypass can be performed, if hypothermia, hypoxia, acidosis, or low-flows are being avoided. Due to the lack of data, the adequate approach is still intuitive and requires standardization.

scholarly journals The additional genetic diagnosis of homozygous sickle cell disease in a patient with Waardenburg-Shah syndrome: a case report

2019 ◽  
Vol 13 (1) ◽  
Author(s):  
Angela E. Rankine-Mullings ◽  
Graham Serjeant ◽  
Zachary Ramsay ◽  
Neil A. Hanchard ◽  
Monika Asnani
Keyword(s):  
Case Report ◽  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Genetic Diagnosis ◽  
Cell Disease ◽  
Homozygous Sickle Cell Disease

scholarly journals eComment: Cardiopulmonary bypass without exchange transfusion in sickle cell disease – An update

2010 ◽  
Vol 10 (1) ◽  
pp. 68-69 ◽  
Author(s):  
Frank Edwin ◽  
Ernest Aniteye ◽  
Martin Tamatey ◽  
Kwabena Frimpong-Boateng
Keyword(s):  
Cardiopulmonary Bypass ◽  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Exchange Transfusion ◽  
Cell Disease

Exchange Transfusion Before Cardiopulmonary Bypass in Sickle Cell Disease

2010 ◽  
Vol 90 (1) ◽  
pp. 323-324 ◽  
Author(s):  
Karl A. Bocchieri ◽  
S. Jacob Scheinerman ◽  
L. Michael Graver
Keyword(s):  
Cardiopulmonary Bypass ◽  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Exchange Transfusion ◽  
Cell Disease

scholarly journals Perioperative Management of Sickle Cell Disease in Paediatric Cardiac Surgery

2007 ◽  
Vol 35 (5) ◽  
pp. 792-795 ◽  
Author(s):  
K. Bhatt ◽  
S. Cherian ◽  
R. Agarwal ◽  
S. Jose ◽  
K. M. Cherian
Keyword(s):  
Cardiopulmonary Bypass ◽  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Exchange Transfusion ◽  
Septal Defect ◽  
Cell Disease ◽  
Total Blood ◽  
Surgical Closure ◽  
Cold Cardioplegia ◽  
Haemoglobin S

In sickle cell disease, cardiopulmonary bypass may induce red cell sickling. Partial exchange transfusion reduces the circulating haemoglobin S level. We report the management of a child with sickle cell disease who required surgical closure of a ventricular septal defect. Preoperative exchange transfusion of 50% of the total blood volume was performed with fresh packed red cells over three days. Further exchange transfusion was performed as cardiopulmonary bypass commenced. The haemoglobin S level was reduced from 76% to 37%. The blood removed from the patient during the exchanges was processed allowing storage and re-infusion of the patient's plasma and platelets. Combined preoperative and intraoperative exchange transfusions, instead of a single stage 50% volume exchange, was effective and potentially avoids larger haemodynamic effects. Cardiopulmonary bypass was conducted at normothermia and cold cardioplegia was avoided (fibrillatory arrest was used during the surgical repair).

scholarly journals Acute chest syndrome in sickle cell disease/HBE patient, A case report

2021 ◽  
Author(s):  
Ibrahim Khamees ◽  
mohamed yassin ◽  
Waail Rozi
Keyword(s):  
Case Report ◽  
Sickle Cell Disease ◽  
Rare Disease ◽  
Sickle Cell ◽  
Male Patient ◽  
Exchange Transfusion ◽  
Acute Chest Syndrome ◽  
Cell Disease ◽  
Hemoglobin E ◽  
Benign Condition

Hemoglobin S (HBS) and hemoglobin E (HBE) are common hemoglobinopathies, but combined heterozygosity of HBS and HBE (HBSE) is relatively a rare disease. Most reports suggest that HBSE is generally benign condition. In this report we describe a 17-year-old male patient presenting with acute chest syndrome treated with exchange transfusion.

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