scholarly journals Factors that predict a positive response on gonadotropin-releasing hormone stimulation test for diagnosing central precocious puberty in girls

2013 ◽  
Vol 18 (4) ◽  
pp. 202 ◽  
Author(s):  
Junghwan Suh ◽  
Myung Hyun Choi ◽  
Ah Reum Kwon ◽  
Ye Jin Kim ◽  
Jin Woo Jeong ◽  
...  
Keyword(s):  
Precocious Puberty ◽  
Positive Response ◽  
Central Precocious Puberty ◽  
Gonadotropin Releasing Hormone ◽  
Stimulation Test ◽  
Releasing Hormone ◽  
Hormone Stimulation

A Single-sample, Subcutaneous Gonadotropin-releasing Hormone Test for Central Precocious Puberty

PEDIATRICS ◽  
1996 ◽  
Vol 97 (4) ◽  
pp. 517-519
Author(s):  
Kathryn L. Eckert ◽  
Darrell M. Wilson ◽  
Laura K. Bachrach ◽  
Henry Anhalt ◽  
Reema L. Habiby ◽  
...  
Keyword(s):  
Precocious Puberty ◽  
Central Precocious Puberty ◽  
Gonadotropin Releasing Hormone ◽  
Stimulation Test ◽  
Single Sample ◽  
Releasing Hormone ◽  
Serum Luteinizing Hormone ◽  
Serum Lh ◽  
Laboratory Confirmation ◽  
Multiple Sample

Objective. We compared a rapid, subcutaneous (SQ), single-sample gonadotropin-releasing hormone (GnRH) stimulation test with the standard multiple-sample, intravenous (IV) GnRH stimulation test used in the evaluation of central precocious puberty (CPP). Methods. We evaluated 22 patients presenting with evidence of precocious puberty. GnRH (100 µg) was administered subcutaneously in the clinic setting with single serum luteinizing hormone (LH) measured 40 minutes after injection. A standard IV GnRH stimulation test was performed within 2 weeks, with serum LH obtained at 0, 20, 40, and 60 minutes. LH was assayed by immunochemiluminometric assay. Results. The mean peak LH levels after IV and SQ testing were identical. A significant correlation (r = .88) was found between the LH determined by SQ stimulation and the peak LH determined by IV GnRH testing. CPP was diagnosed (LH, ≥8 IU/L) by both SQ and IV testing in 7 of 22 patients and was excluded by both tests in 14 of 22 patients. A diagnostic discrepancy between peak IV and SQ results was seen in 1 patient. Conclusions. We conclude that mean GnRH-stimulated LH levels from rapid SQ and standard IV testing are indistinguishable and that individual LH levels by each method are strongly correlated. A rapid SQ GnRH test is a valid tool for laboratory confirmation of CPP.

scholarly journals Gonadotropin-releasing Hormone Stimulation Test for Precocious Puberty

2011 ◽  
Vol 31 (4) ◽  
pp. 244-249 ◽  
Author(s):  
Han Kyul Kim ◽  
Seung Jung Kee ◽  
Ji Yeon Seo ◽  
Eun Mi Yang ◽  
Hong Jae Chae ◽  
...  
Keyword(s):  
Precocious Puberty ◽  
Gonadotropin Releasing Hormone ◽  
Stimulation Test ◽  
Releasing Hormone ◽  
Hormone Stimulation
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