Soluble CD147 (BSG) as a Prognostic Marker in Multiple Myeloma

CD147 (basigin, BSG) is a membrane-bound glycoprotein involved in energy metabolism that plays a role in cancer cell survival. Its soluble form is a promising marker of some diseases, but it is otherwise poorly studied. CD147 is overexpressed in multiple myeloma (MM) and is known to affect MM progression, while its genetic variants are associated with MM survival. In the present study, we aimed to assess serum soluble CD147 (sCD147) expression as a potential marker in MM. We found that sCD147 level was higher in MM patients compared to healthy individuals. It was also higher in patients with more advanced disease (ISS III) compared to both patients with less advanced MM and healthy individuals, while its level was observed to drop after positive response to treatment. Patients with high sCD147 were characterized by worse overall survival. sCD147 level did not directly correlate with bone marrow CD147 mRNA expression. In conclusion, this study suggests that serum sCD147 may be a prognostic marker in MM.

Evaluation of Continuous Inhaled Epoprostenol in the Treatment of Acute Respiratory Distress Syndrome, Including Patients With SARS-CoV-2 Infection

Background Acute respiratory distress syndrome (ARDS) management is primarily supportive. Pulmonary vasodilators, such as inhaled epoprostenol (iEPO), have been shown to improve PaO2:FiO2 (PF) and are used as adjunctive therapy. Objective To identify the positive response rate and variables associated with response to iEPO in adults with ARDS. A positive response to iEPO was defined as a 10% improvement in PF within 6 hours. Methods This retrospective study included adults with ARDS treated with iEPO. The primary endpoint was the variables associated with a positive response to iEPO. Secondary endpoints were positive response rate and the change in PF and SpO2:FiO2 within 6 hours. Statistical analysis included multivariable regression. Results Three hundred thirty-one patients were included. As baseline PF increased, the odds of responding to iEPO decreased (odds ratio [OR], 0.752, 95% CI, 0.69-0.819, p < 0.001). Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-related ARDS (OR 0.478, 95% CI, 0.281-0.814, p = 0.007) was associated with decreased odds of a positive response to iEPO. The total population had a 68.3% positive response rate to iEPO. SARS-CoV-2-related ARDS and non-SARS-CoV-2-related ARDS had a 59.5% and 72.7% positive response rate, respectively. iEPO significantly improved PF (71 vs 95, P < 0.001) in the whole population. Conclusion and Relevance iEPO was associated with a positive effect in a majority of moderate-to-severe ARDS patients, including patients with SARS-CoV-2-related ARDS. Lower baseline PF and non-SARS-CoV-2-related ARDS were significantly associated with a positive response to iEPO. The ability to predict which patients will respond to iEPO can facilitate better utilization.

PENGEMBANGAN KOMIK DIGITAL CHLOROPHYL SEBAGAI MEDIA PEMBELAJARAN PEDULI LINGKUNGAN SISWA SMA

The loss of a sense of responsibility that students have towards protecting and preserving nature is also a bad impact of the progress that has occurred in the present era. Therefore, the researchers took the initiative to develop a valid and practical "chlorophyll" digital comic-based learning media to be used in instilling concern for the surrounding environment. The method used in this research is developing research using ADDIE (Analyze, Design, Development, Implementation, and Evaluation) procedures. The development of this digital Chlorophyl comic consists of 12 pages starting from the opening page about the introduction of the main character, problems to solutions that can be done to protect the environment. Chlorophyl digital comics can be said to be valid with an average of 3.58 and have good criteria so that they can be used in the field with a few revisions that have been adapted to suggestions from experts. In addition, based on input from the validator with several notes of improvement and the assessment of student responses to chlorophyll digital comics, it was stated that it was very practical with a positive response of 80.59%. The conclusion obtained is that the digital chlorophyll comic that was developed is said to be valid with a value of 3.5 and stated to be very practical with a positive response of 80.59%. ABSTRAKHilangnya rasa tanggung jawab yang dimiliki para pelajar terhadap menjaga dan melestarikan alam juga menjadi dampak buruk dari kemajuan yang terjadi pada era masa kini. Oleh karena itu, peneliti bernisiatif untuk mengembangkan media pembelajaran berbasis komik digital chlorophyl yang valid dan praktis untuk digunakan dalam menanamkan kepedulian terhadap lingkungan sekitar. Metode yang digunakan dalam penelitian ini adalah penelitian mengembangkan dengan prosedur ADDIE (Analyze, Design, Development, Implementation, and Evaluation). Pengembangan komik digital Chlorophyl ini terdiri atas 12 halaman mulai dari halaman pembuka tentang perkenalana tokoh utama, permasalahan hingga solusi yang bisa dilakukan untuk menjaga lingkungan hidup. Komik digital Chlorophyl dapat dikatakan valid dengan rata-rata yaitu 3,58 dan memiliki kriteria baik sehingga dapat digunakan di lapangan dengan sedikit revisi yang telah disesuaikan dengan saran dari para ahli. Selain itu berdasarkan masukan dari validator dengan beberapa catatan perbaikan dan penilaian angket respon siswa terhadap komik digital chlorophyl dinyatakan sangat praktis dengan respon positif sebanyak 80,59%. Kesimpulan yang didapatkan adalah komik digital chlorophyl yang dikembangkan dikatakan valid dengan nilai 3,5 dan dinyatakan sangat praktis dengan respon positif sebanyak 80,59%.

PENGEMBANGAN MEDIA E-BOOK AUDIO VISUAL MENGGUNAKAN FLIPBOOK MATERI TRIGONOMETRI KELAS XI IPA BERBASIS HYBRID LEARNING

The COVID-19 pandemic that has hit the world since 2019 has resulted in the world of education in Indonesia, which was initially required to conduct online or online learning at home. Until now, the number of Covid cases in Indonesia has decreased. Finally, the education office has implemented a hybrid learning system or offline and online learning. . Solutions for hybrid learning through several applications such as Whatsapp groups, Zoom, Google classroom, Google meet, Quipper and so on. With this application, teachers are required to be creative in delivering hybrid learning, therefore in addition to using this application, researchers use flipbooks to support hybrid learning. The method in this study using ADDIE namely Analysis, Design, Development, Implementation and Evaluation. The purpose of this study is to provide meaningful and fun learning and not boring without giving assignments that are too heavy so that it makes students uncomfortable because there are many assignments and too much material is delivered in a monotonous way. The results from the validation of the expert team were obtained at 86.5%, which means that the e-book is very suitable to be used and received a positive response with a percentage value of 89.5% resulting in a positive response. The conclusion that can be narrowed is that e-learning online learning using Flipbook with trigonometry material for class XI Science is declared effective because students can understand trigonometry material even though the learning is done in a hybrid way. ABSTRAKPandemi covid-19 yang melanda dunia sejak tahun 2019 mengakibatkan dunia pendidikan di Indonesia yang awalnya diharuskan melakukan pembelajaran secara daring atau dalam jaringan yang dilakukan dirumah hingga saat ini kasus covid di Indonesia semakin menaurun akhirnya dinas pendidikan memberlakukan sistem pembelajaran secara hybrid atau pembelajaran luring dan daring. Solusi untuk pembelajaran hybrid melalui beberapa aplikasi seperti Whatsapp grup, Zoom, Google classroom, Google meet, Quipper dan lain sebagainya. Dengan aplikasi tersebut guru dituntut kreatif dalam menyampaikan pembelajaran secara hybrid, oleh karena itu selain menggunakan aplikasi tersebut peneliti menggunakan flipbook untuk penunjang pembelajaran hybrid. Metode pada penelitian ini menggunakan ADDIE yaitu Analisis, Design, Development, Implementasi dan Evaluasi. Tujuan dari penelitian ini untuk memberikan pembelajaran bermakna serta menyenangkan dan tidak membosankan tanpa memberikan tugas yang terlalu berat sehingga membuat peserta didik tidak nyaman karena banyak tugas dan terlalu banyak materi yang disampaikan dengan cara monoton. Hasil dari validasi tim ahli didapat sebesar 86,5% dengan artian e-book sangat layak digunakan dan mendapat respon positif dengan nilai presentase 89,5% menghasilkan respon positif. Kesimpulan yang dapat dikerucutkan adalah pembelajaran daring secara e-learning menggunakan Flipbook dengan materi trigonometri kelas XI IPA dinyatakan efektif karena peserta didik dapat paham materi trigonometri meskipun pembelajaran dilakukan secara hybrid

STATISTICAL OPTIMIZATION AND EVALUATION OF ETHOSOMAL MICONAZOLE NITRATE SUSPENSION

Objective: The objectives of the present study were to optimize and evaluate the ethosomal suspension of miconazole nitrate for the treatment of local and systemic fungal infections. Methods: Miconazole topical formulation is prepared for better patient compliance and to reduce the dose of a drug. Miconazole nitrate ethosomes were prepared by the cold method using factorial designing with Ethanol(X1), IPA(Isopropyl alcohol)(X2), and Lecithin(X3) as Independent variables and % EE(Entrapment efficiency)(Y1) and % DR(drug release at 8th h)(Y2) was selected as responses. Results: The results obtained in the design showed that there was no significant interaction among factors. The lecithin concentration had a positive response on % EE, while ethanol concentration and IPA had a positive effect. For % DR, Ethanol, and IPA showed a positive effect and Lecithin had a negative response. The formulation EM22 (3 ml X1,3 ml X2 and 300 mg of X3) characterized by high % EE(77.3 %) and optimum % DR(94.2%) and formulation EM6 (2 ml X1,2 ml X2 and 100 mg of X3) characterized by high % DR(97.32 %) and optimum % EE (74.8 %). EM22 was incorporated in the gel as it is showing more entrapment efficiency and compared with the marketed product for drug release. Conclusion: From the result, it was concluded that formulated ethosomal suspension and optimized gel have more drug release than marketed formulation so that formulated suspension can be used for the preparation of antifungal gels, creams, ointments for sustained release.

Experience of Parents of Children with Genetically Determined Leukoencephalopathies Regarding the Adapted Health Care Services During the COVID-19 Pandemic

Parents of children with genetically determined leukoencephalopathies play a major role in their children's health care. Because of the COVID-19 pandemic, many health care services were suspended, delayed or delivered remotely with telemedicine. We sought to explore the experience of parents of children with genetically determined leukoencephalopathies during the pandemic given the adapted health care services. We conducted semistructured interviews with 13 parents of 13 affected children. Three main themes were identified using thematic analysis: perceived impact of COVID-19 on health care services, benefits and challenges of telemedicine, and expectations of health care after the pandemic. Parents perceived a loss/delay in health care services while having a positive response to telemedicine. Parents wished telemedicine would remain in their care after the pandemic. This is the first study assessing the impact of COVID-19 on health care services in this population. Our results suggest that parents experience a higher level of stress owing to the shortage of services and the children's vulnerability.

Pengembangan Perangkat Pembelajaran dengan Menggunakan Model Team Based Learning untuk Meningkatkan Hasil Belajar Fisika

This research was conducted at SMA Negeri 1 Telaga Biru and aimed to produce quality physics learning tools using the Team-Based Learning (TBL) learning model. The device was developed using the 4D development model developed by Thiagarajan Semel and Semel. The research results on the device show that the developed device is of high quality. Learning tools are said to be valid for use with slight revisions. This can be seen based on the average validation results with a value of 3.5 and 3.6. The level of effectiveness of learning devices is seen in the increase in student learning outcomes consisting of the cognitive domain at the first meeting until the third meeting, N Gain iRat is 0.46 with n criteria of moderate gain, at tRat is N Gain 0.5, in the attitude domain with an average the percentage of 80.240%, the results of observing student activities for 3 meetings are 80.890% with good criteria and the psychomotor aspect an average percentage of 80.128%, and the practicality of the developed device seen from the observation sheet on the implementation of learning 93.650% and the teacher's response questionnaire and student responses with an average percentage of 81.653% and 79.752%. Get a positive response.

The effect of project management through e-business and garage sales on poverty reduction

Poverty is one of the significant problems, and almost all countries worldwide face poverty issues that negatively impact society. This study is written to investigate the students' knowledge and awareness of poverty and interest level in conducting e-business and garage sales. Also, examine the relationship of knowledge and awareness on students' intention to conduct e-business and garage sales. There were 152 respondents from the same university who participated in this study. The data analyzed using descriptive and inferential statistics performed by SPSS-23 and SmartPLS 3.3.3. The survey showed that the student's knowledge and awareness of poverty are still lacking and need improvement. Half of the respondents said they are not familiar with SDG1, and they were not aware that their university has done an event related to SDG1 and poverty. There were 25% and 85% of students interested in conducting e-business and garage sales that increased their pocket money and reduced poverty rates among university students. Overall, this study's result shows a positive response from all respondents, and most of them have general ideas of poverty. In addition, this study has identified that the variable knowledge and awareness have a significant positive effect on student's intention to conduct e-business and garage sales.

Student Sustainability Disposition: Where Are Students’ Levels?

<p class="Abstrakabstract">Education for sustainability development (ESD) is a way to realize that every individual lives interdependently with each other and their environment. Research has been conducted with survey methods to reveal the level of students’ disposition/attitude to sustainable living, being a basis for the development of appropriate learning. The research sample was 95 students at SMPN Garut. The data in this study is primary data, which is obtained directly from the research subject. The research was conducted by delivering questionnaires to students consisting of 51 closed question items. The results of the study obtained the average of student disposition score from several ESD themes, namely the environment, waste, water, energy, natural disasters, and health respectively is 2.99, 3.15, 3.24, 3.11, 3.08 and 3.33. The average of these all themes is 3.15. Based on this study, the results were obtained that students' sustainability disposition/attitude are at a high level. The positive response given by students shows the attitude of students who support the efforts to realize sustainable development. In this case, there is no guarantee if someone who have good sustainability disposition will have good sustainability practice. Sustainable disposition/attitude must be supported by sustainable behaviors and practices so that sustainable living goals can be achieved. The last, Indonesia government can make the policy and guidelines related to how to do effective sustainability education in Indonesia to support sustainability awareness of students and society.</p>

Efforts to improve the physical quality of the elderly through the healthy living community movement (GERMAS) in Petiga Village

The death rate due to Covid-19 has continued to increase since it was first announced in early March 2020. This community service is carried out with the Healthy Living Community Movement (Germas) approach, one of which is physical activity. The activities were carried out using an educative and persuasive method for 4 months, starting from August to November 2021. This community service includes three types of activities, namely training and yoga assistance for elderly cadres, training in making herbal drinks (loloh) and establishing a tracking path for the elderly in Petiga Village. From a series of programs, the people of Petiga Village gave a positive response. These activities are able to provide benefits in accordance with the health problems of the elderly.