Successful treatment of venous leg ulcer with platelet-rich fibrin

The autologous platelet-rich blood derivatives have been used in bioregenerative medicine for decades in various indications including the facilitation of wound healing. Leukocyte- and platelet-rich fibrin (PRF) is a second-generation autologous blood-derived product, which can be obtained relatively easily and at low cost. PRF is rich in growth factors and antimicrobial proteins that are released by activated platelets and leukocytes. The authors present a successful treatment of a venous leg ulcer providing a detailed presentation of the PRF method.