scholarly journals Hydroxyethyl starches in burns

2016 ◽  
Vol 106 (7) ◽  
pp. 646
Author(s):  
Alan David Rogers ◽  
Daan Den Hollander
Keyword(s):  
Hydroxyethyl Starches

The Effects of Hydroxyethyl Starches on Intracellular Calcium in Platelets

2002 ◽  
Vol 95 (4) ◽  
pp. 866-869 ◽  
Author(s):  
Thomas Gamsjäger ◽  
Burkhard Gustorff ◽  
Sibylle A. Kozek-Langenecker
Keyword(s):  
Intracellular Calcium ◽  
Hydroxyethyl Starches

Update of use of hydroxyethyl starches in surgery and trauma

2015 ◽  
Vol 78 ◽  
pp. S54-S59 ◽  
Author(s):  
Richard B. Weiskopf ◽  
Michael F.M. James
Keyword(s):  
Hydroxyethyl Starches

scholarly journals Effects of hydroxyethyl starches on hemostasis

2007 ◽  
Vol 9 (3) ◽  
pp. 173-181 ◽  
Author(s):  
SIBYLLE A. KOZEK-LANGENECKER ◽  
GISELA SCHARBERT
Keyword(s):  
Hydroxyethyl Starches

scholarly journals Hydroxyethyl Starches

2009 ◽  
Vol 111 (1) ◽  
pp. 187-202 ◽  
Author(s):  
Martin Westphal ◽  
Michael F. M. James ◽  
Sibylle Kozek-Langenecker ◽  
Reto Stocker ◽  
Bertrand Guidet ◽  
...  
Keyword(s):  
Tissue Storage ◽  
High Doses ◽  
First And Second Generation ◽  
New Generation ◽  
Clinical Potential ◽  
The Impact ◽  
Hydroxyethyl Starches ◽  
Lower Molar

With the development of a new generation of hydroxyethyl starches (HES), there has been renewed interest in their clinical potential. High doses of first- and second-generation HES were associated with adverse effects on renal function, coagulation, and tissue storage, thereby limiting their clinical applicability. Newer HES products have lower molar substitution and in vivo molecular weight, resulting in more rapid metabolism and clearance. In this review article, the differences between HES generations are highlighted, with particular emphasis on the improved safety profile of the third generation products. These improvements have been achieved with no loss of efficacy, and they contradict the assumption that efficacy of HES solutions is directly linked to plasma concentration. The impact of source material on structure and pharmacokinetics is highlighted, and the role of the carrier solution is critically assessed.

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