First- and Second-generation Health Condition Affected by Radiation

Research relevance: article presents the incidence of children and grandchildren for 2018–2019 of liquidator workers who took part in cleaning up the contaminated area around the Chernobyl nuclear power plant, as well as residents evacuated from the city of Pripyat and other settlements within a radius of 70 km from the station. The consequences of radiation exposure of Chernobyl accident remain a topical issue. Research objectives: in order to study health status of children and grandchildren of liquidators, outpatient cards and reporting forms no. 15-zdrav “On medical care for people affected by radiation and included in the Kyrgyz State Medical and Dosimetric Register” examined. Research materials and methods: diseases of the endocrine and nervous systems, nutritional disorders, metabolic disorders, mental disorders, diseases of the eye and its adnexa, ear diseases of and mastoid process were studied. Circulatory and respiratory system diseases were analyzed. Research results: animal and cell culture studies show that high doses of ionizing radiation can lead to mutations in offspring. However, there have not been sufficiently large-scale studies on humans that would allow assessing the effect of radiation on the health of offspring. The exposure provokes mutations and incurable diseases, but it is still unclear how it might affect the children affected. It is known that exposure to ionizing radiation increases DNA mutagenesis compared to background values. Conclusions: obtained data substantiate the need for further monitoring of their health, organization of differentiated dispensary observation of this contingent and timely implementation of medical, rehabilitation and preventive measures in order to preserve health of “children and grandchildren of Chernobyl” at all subsequent stages of their life.

Immigrant–Native Wage Gaps at Work: How the Public and Private Sectors Shape Relational Inequality Processes

We investigate how the institutional context of the public and private sectors regulates the association of workplace diversity policies and relational status positions with first- and second-generation immigrants’ wages. Using unique linked employer–employee data combining administrative and survey information of 6,139 employees in 120 German workplaces, we estimate workplace fixed-effects regressions. Workplace processes are institutionally contingent: diversity policies such as mixed teams reduce inequalities in the public sector, and diversity policies such as language courses reinforce existing inequalities in the private sector. In public sector workplaces where natives hold higher relational positions, immigrants’ wages are lower. This group-related dynamic is not detectable in the private sector.

Migrants’ Social Integration and Its Relevance for National Identification: An Empirical Comparison Across Three Social Spheres

A key element of migrants’ well-being is their emotional integration, that is, the extent to which they perceive themselves as members of society and their identification with the country they are living in. To foster this sense of belonging, many integration programs aim to increase the migrants’ social integration, for example, by organizing events for migrants to meet natives in various settings. The validity of this strategy is supported by decades of international research. It remains unclear, however, which aspects of social integration are most relevant for national identification. Multiple theories concerned with contact and group identification support the assumption that contact to natives should foster a sense of belonging and national identification. However, for a contact situation to bear this potential, a certain set of criteria, including aspects like direct personal contact, a similar social status, and the presence of egalitarian norms, needs to be fulfilled. It is expected that these characteristics are more likely to be fulfilled within family and friendship settings than in contact situations within the employment context. Hence, I expect contact to natives within the network of friends and family to be more greatly associated with migrants’ national identification. I analyzed data from a 2013 cooperation between the Institute for Employment Research (IAB) and the German Socio-Economic Panel (SOEP), that is, the IAB-SOEP Migration Sample, as well as the 2014 wave of the SOEP. The subsample used included 2,780 first- and second-generation migrants living in Germany. The results indicate that not all kinds of contact are equally linked to national identification. In contrast to expectations, in neither the cross-sectional models nor the lagged models was living together with native family members significantly linked to national identification. Similarly, the association between having predominantly native co-workers and national identification was insignificant when controlling for migrant-specific characteristics. Only the relation with having predominantly native friends was significant and positive across all models. This as well as a comparison of the associations lead to the conclusion that when it comes to migrants’ national identification native friends might be the most relevant form of contact to natives.

Steinernema Feltiae- Xenorhabdus Bovienii: More Information about this Bactohelminthic Complex from Iran

Background: Entomopathogenic nematodes (EPNs) of the families Steinernematidae and Heterorhabditidae that are symbiotically associated with Xenorhabdus and Photorhabdus bacteria are one of the effective biological control agents of insect pests. Native isolates can probably be more efficacious to control insect pests than exotic ones due to their adaptability to indigenous environmental conditions. Results: In this study, Steinernema feltiae isolate FUM221 was recovered from soil samples collected from the Fandoghloo pasture, Ardabil province, Iran. Morphological investigations of the first and second-generation adults, infective juveniles, and molecular characterizations were given based on ITS and 18S rDNA genes. Besides, molecular analysis based on the 16S rRNA region and phenetic data recognized Xenorhabdus bovienii as its symbiont bacterium. The scanning electron microscopy (SEM) images verified the identification of this isolate.Conclusion: The molecular characterization using two loci and phylogenetic analyses provided more evidence for the classification of this steinernematid and its difference of the same species from other countries. Moreover, molecular and phenetic characterizations of its symbiotic bacterium were provided with low variations compared to other isolates. Herein, the comprehensive taxonomic data of this steinernematid from Iran is presented.

Community multiculturalism and immigrant crime

There is considerable international and local-level variation in immigrant crime. In this article, we propose a theoretical model to better understand that contextual variation. Furthermore, we present the results of our first attempts to empirically assess the validity of the framework, focussing on local-level variation in crime among residents of Turkish or Moroccan origin in the Netherlands. The proposed model connects Berry's acculturation theory to criminological theories, using relevant findings from the immigration acculturation literature as starting points. It theorises that host societies with a ‘multicultural acculturation orientation’ tend to reduce immigrant crime by fostering informal social control and attenuating criminogenic strains. The empirical analyses explore whether local-level variation in multicultural attitudes among the native-Dutch indeed predicts municipal variation in the number of registered suspected crimes among first- and second-generation immigrants, focussing on men of Turkish or Moroccan origin residing in 35 Dutch cities. The empirical analyses are based on a unique database that combines aggregated survey data, which were used to measure natives’ acculturation attitudes, with administrative microdata, including micro-level police data. Evidence is found for a protective effect of local-level multiculturalism for first-generation immigrant crime in particular, especially for immigrant men living in larger local immigrant communities. We also find stronger effects for the more cohesive and societally accepted Turkish-Dutch group than for the more fragmented and excluded Moroccan-Dutch.

A Bibliometric and Visualized Analysis of Cardiac Regeneration Over a 20-Year Period

Background: Recent research has suggested that cardiac regeneration may have the widely applicable potential of treating heart failure (HF). A comprehensive understanding of the development status of this field is conducive to its development. However, no bibliometric analysis has summarized this field properly. We aimed to analyze cardiac regeneration-related literature over 20 years and provide valuable insights.Methods: Publications were collected from the Web of Science Core Collection (WoSCC). Microsoft Excel, VOSviewer, CiteSpace, and alluvial generator were used to analyze and present the data.Results: The collected 11,700 publications showed an annually increasing trend. The United States and Harvard University were the leading force among all the countries and institutions. The majority of articles were published in Circulation Research, and Circulation was the most co-cited journal. According to co-citation analysis, burst detection and alluvial flow map, cardiomyocyte proliferation, stem cells, such as first-and second-generation, extracellular vesicles especially exosomes, direct cardiac reprogramming, macrophages, microRNAs, and inflammation have become more and more popular recently.Conclusions: Cardiac regeneration remains a research hotspot and develops rapidly. How to modify cardiac regeneration endogenously and exogenously may still be the hotspot in the future and should be discussed more deeply.

Real Life Comparison of Afatinib and Erlotinib in Non-small Cell Lung Cancer With Rare EGFR Exon 18 and Exon 20 Mutations: a Turkish Oncology Group (TOG) Study.

Objectives To compare the survival of first- and second-generation tyrosine kinase inhibitors (TKIs) in patients with rare EGFR exon 18 and exon 20 mutation-positive non-small cell lung cancer (NSCLC).Materials and Methods We retrospectively evaluated survival characteristics of 125 patients with EGFR exon 18 and exon 20 mutated NSCLC who received erlotinib or afatinib as first line treatment between 2012 and 2021 from 34 oncology centres. Since exon 20 insertion is associated with TKI resistance, these 18 patients were excluded from the study.Results EGFR exon 18 mutations were seen in 60%, exon 20 mutations in 16%, and complex mutations in 24% of the patients with NSCLC who were evaluated for the study. There were 75 patients in erlotinib treated arm and 50 patients in afatinib arm. Patients treated with erlotinib had progression-free survival time (PFS) of 8.0 months and PFS was 7.0 months in the afatinib arm (p=0.869), while overall survival time (OS) was 20.0 vs 24.8 months, respectively (p=0.190). PFS of exon 18 mutated arm was 7.0 months, exon 20 mutated arm was 4.3 months, and complex mutation positive group was 17.3 months, and this was statistically significant (p=0.036). The longest OS was 32.5 months, seen in the complex mutations group, which was not statistically different than exon 18 and in exon 20 mutated groups (21.0 and 21.2 months, respectively) (p=0.323).Conclusion In this patient group, especially patients with complex mutations are as sensitive to EGFR TKI treatment similar to classical mutations, and in patients with rare exon 18 and exon 20 EGFR mutation both first- and second-generation EGFR-TKIs should be considered, especially as first- and second-line options.