scholarly journals Objective pain sensitivity affects sleep quality in opioid dependent males on methadone maintenance therapy

2014 ◽  
Author(s):  
Zalina Zahari ◽  
Chee Siong Lee ◽  
Soo Choon Tan ◽  
Nasir Mohamad ◽  
Yeong Yeh Lee ◽  
...  
Keyword(s):  
Maintenance Therapy ◽  
Sleep Quality ◽  
Pain Sensitivity ◽  
Methadone Maintenance ◽  
Methadone Maintenance Therapy ◽  
Pain Tolerance ◽  
Opiate Withdrawal ◽  
Tolerance Time ◽  
Male Patients ◽  
The Mean

Aim Pain associated poor sleep quality has been reported among opioid dependent patients on methadone maintenance therapy (MMT) but objective pain data are lacking. This study aimed to investigate the rate of objective pain sensitivity and the relationship between pain sensitivity and sleep quality in this susceptible male population. Methods A total of 168 male patients from MMT clinic in Kelantan, Malaysia were included into the study. Objective pain tolerance to cold pressor test (CPT) was evaluated at 0 hour and at 24 hours after the first CPT. Malay version of the Pittsburgh Sleep Quality Index – PSQI and the subjective opiate withdrawal scale (SOWS) questionnaires were administered to evaluate the quality of sleep and withdrawal symptoms, respectively. Results The mean age of the study participants was 37.22 (SD 6.20) years old. The mean daily methadone dose was 76.64 (SD 37.63) mg/day. The mean averaged SOWS score was 5.43 (SD 6.91). The averaged pain tolerance time ranged from 7 to 300 s with a mean time of 32.16 (SE 2.72) s, slightly below the cut-off score of 37.53 s. More specifically, 78.6% (n = 132) of patients were identified as ‘pain-sensitive’ (averaged pain tolerance time ≤ 37.53 s), and 36 (21.4%) were ‘pain-tolerant’ patients (averaged pain tolerance time > 37.53 s). The mean global PSQI score was 5.47 (SD 2.74). The pain-sensitive patients reported poorer sleep quality with mean (SD) of 5.78 (2.80) compared with pain-tolerant patients with mean (SD) of 4.31 (2.18) (p = 0.005). With analysis of covariance, pain-sensitive patients were found to have higher global PSQI scores (adjusted mean 5.76, 95% CI 5.29; 6.22) than pain-tolerant patients (adjusted mean 4.42, 95% CI 3.52; 5.32) (p = 0.010). Conclusions Many opioid dependent male patients on MMT are pain-sensitive. A poorer sleep quality is associated with objective pain sensitivity. Pain and sleep complaints in this susceptible population should not be overlooked.

scholarly journals Objective pain sensitivity affects sleep quality in opioid dependent males on methadone maintenance therapy

2014 ◽  
Author(s):  
Zalina Zahari ◽  
Chee Siong Lee ◽  
Soo Choon Tan ◽  
Nasir Mohamad ◽  
Yeong Yeh Lee ◽  
...  
Keyword(s):  
Maintenance Therapy ◽  
Sleep Quality ◽  
Pain Sensitivity ◽  
Methadone Maintenance ◽  
Methadone Maintenance Therapy ◽  
Pain Tolerance ◽  
Opiate Withdrawal ◽  
Tolerance Time ◽  
Male Patients ◽  
The Mean

Aim Pain associated poor sleep quality has been reported among opioid dependent patients on methadone maintenance therapy (MMT) but objective pain data are lacking. This study aimed to investigate the rate of objective pain sensitivity and the relationship between pain sensitivity and sleep quality in this susceptible male population. Methods A total of 168 male patients from MMT clinic in Kelantan, Malaysia were included into the study. Objective pain tolerance to cold pressor test (CPT) was evaluated at 0 hour and at 24 hours after the first CPT. Malay version of the Pittsburgh Sleep Quality Index – PSQI and the subjective opiate withdrawal scale (SOWS) questionnaires were administered to evaluate the quality of sleep and withdrawal symptoms, respectively. Results The mean age of the study participants was 37.22 (SD 6.20) years old. The mean daily methadone dose was 76.64 (SD 37.63) mg/day. The mean averaged SOWS score was 5.43 (SD 6.91). The averaged pain tolerance time ranged from 7 to 300 s with a mean time of 32.16 (SE 2.72) s, slightly below the cut-off score of 37.53 s. More specifically, 78.6% (n = 132) of patients were identified as ‘pain-sensitive’ (averaged pain tolerance time ≤ 37.53 s), and 36 (21.4%) were ‘pain-tolerant’ patients (averaged pain tolerance time > 37.53 s). The mean global PSQI score was 5.47 (SD 2.74). The pain-sensitive patients reported poorer sleep quality with mean (SD) of 5.78 (2.80) compared with pain-tolerant patients with mean (SD) of 4.31 (2.18) (p = 0.005). With analysis of covariance, pain-sensitive patients were found to have higher global PSQI scores (adjusted mean 5.76, 95% CI 5.29; 6.22) than pain-tolerant patients (adjusted mean 4.42, 95% CI 3.52; 5.32) (p = 0.010). Conclusions Many opioid dependent male patients on MMT are pain-sensitive. A poorer sleep quality is associated with objective pain sensitivity. Pain and sleep complaints in this susceptible population should not be overlooked.

scholarly journals Depression in male patients on methadone maintenance therapy

2013 ◽  
Vol 5 ◽  
pp. 67-73 ◽  
Author(s):  
Azlin Baharudin ◽  
Noormazita Mislan ◽  
Normala Ibrahim ◽  
Hatta Sidi ◽  
Nik Ruzyanei Nik Jaafar
Keyword(s):  
Maintenance Therapy ◽  
Methadone Maintenance ◽  
Methadone Maintenance Therapy ◽  
Male Patients

scholarly journals Erectile Dysfunction in Methadone Maintenance Therapy

2020 ◽  
Vol 9 (3) ◽  
Author(s):  
Somayeh Motazedian ◽  
Sepehr Entezam ◽  
SeyedShahab Banihashem ◽  
Ghazal Zahed ◽  
Ali Kheradmand
Keyword(s):  
Erectile Dysfunction ◽  
Maintenance Therapy ◽  
Methadone Maintenance ◽  
Pearson Correlation ◽  
Methadone Treatment ◽  
Dose Dependence ◽  
Methadone Maintenance Therapy ◽  
Sexual Disorders ◽  
Cross Sectional ◽  
The Mean

Background: Methadone maintenance therapy (MMT) is one of the most common treatments for drug use complications. Sexual disorders are reported as common side effects of these treatments, the most important of which is erectile dysfunction. Objectives: The present study aimed to evaluate the effects of dose-dependence and duration of methadone treatment on erectile dysfunction in patients undergoing methadone maintenance therapy. Patients and Methods: This cross-sectional study was performed on 192 opioid-dependent men undergoing methadone maintenance treatment at Shariati Hospital in Fasa (Iran) in 2018. Samples were selected by the available sampling method. Each individual was given a demographic questionnaire, methadone consumption questionnaire, and standard erectile dysfunction questionnaire. The one way ANOVA test and, in some cases, Pearson correlation coefficient with chi-square test for qualitative variables were used. Results: Mean age of patients was 41.41 ± 8.41, the mean duration of MMT was 60.53 ± 37.8 months, and the mean therapeutic dose was 83.68 ± 27.07mg. 171 (86.8%) were married, 13 (6.8%) had no erectile dysfunction. While 37 (19.3%) had mild, 78 (19.3%) mild to moderate, 48 (25%) moderate, and 16 (8.3%) had severe erectile dysfunction. The results showed that erectile dysfunction was significantly associated with age and duration of methadone consumption. However, the type of methadone and marital status had no significant association with erectile function. Conclusions: Erectile dysfunction is common in men receiving MMT. The severity of erectile dysfunction is related to the duration of MMT and is not dose-dependent. Therefore, subjects who are on long-term MMT need more frequent erectile dysfunction assessment.

scholarly journals The AC/AG Diplotype for the 118A>G and IVS2 + 691G>C Polymorphisms of OPRM1 Gene is Associated with Sleep Quality Among Opioid-Dependent Patients on Methadone Maintenance Therapy

2016 ◽  
Vol 5 (1) ◽  
pp. 43-54 ◽  
Author(s):  
Zalina Zahari ◽  
Chee Siong Lee ◽  
Muslih Abdulkarim Ibrahim ◽  
Nurfadhlina Musa ◽  
Mohd Azhar Mohd Yasin ◽  
...  
Keyword(s):  
Maintenance Therapy ◽  
Sleep Quality ◽  
Methadone Maintenance ◽  
Methadone Maintenance Therapy ◽  
Oprm1 Gene

scholarly journals Craving for heroin: difference between methadone maintenance therapy patients with and without ADHD

2019 ◽  
Vol 41 (1) ◽  
pp. 83-86
Author(s):  
Maurizio Coppola ◽  
Giuseppe Sacchetto ◽  
Raffaella Mondola
Keyword(s):  
Maintenance Therapy ◽  
Drug Addiction ◽  
Addiction Treatment ◽  
Methadone Maintenance ◽  
Neurodevelopmental Disorder ◽  
Methadone Maintenance Therapy ◽  
Opiate Withdrawal ◽  
Categorical Variables ◽  
Type I ◽  
Treatment Unit

Abstract Introduction Attention deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder persisting in adulthood in 40-60% of cases. Clinical and neuroimaging studies suggest that patients affected by both drug addiction and ADHD show higher rates of craving for drug than patients without ADHD. We designed a pilot open-label study to investigate the effects of ADHD on craving for heroin in methadone maintenance therapy patients. Method Patients were recruited from outpatient facilities in an addiction treatment unit in the municipality of Alba, Italy. They were assessed using the Structured Clinical Interview for DSM-5 (SCID-5), the SCID-5 for Personality Disorders (SCID-5-PD), the Diagnostic Interview for Adult ADHD, second edition (DIVA 2.0), and the Clinical Opiate Withdrawal Scale (COWS). Categorical variables were examined using the chi-square test, and continuous variables, the t-test and Mann-Whitney’s U test for normally and non-normally distributed data, respectively. Data distribution was evaluated using Shapiro-Wilk’s test. Significance was set at p=0.05. Bonferroni correction was applied (0.0063) to avoid type I error. Results A total of 104 patients were included in the study: 14 affected by ADHD (13.5%) and 90 were not affected (86.5%). Patients with ADHD showed higher intensity of craving for heroin than patients without ADHD in the absence of withdrawal symptoms. Conclusion Drug addiction and ADHD share various neurobiological mechanisms that mutually influence the evolution of both disorders. In particular, dopamine dysfunction within various brain circuits may influence impulsivity levels, motivation, inhibitory control, executive functions, and behavior and, consequently, the intensity of craving.

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