Blood Transfusions and the Acquired Immunodeficiency Syndrome

1984 ◽  
Vol 100 (3) ◽  
pp. 461
Author(s):  
JOSEPH HERMAN
Keyword(s):  
Acquired Immunodeficiency Syndrome ◽  
Blood Transfusions ◽  
Acquired Immunodeficiency ◽  
Immunodeficiency Syndrome

Perioperative blood transfusions and cancer recurrence.

1988 ◽  
Vol 6 (8) ◽  
pp. 1348-1354 ◽  
Author(s):  
H S Wu ◽  
A G Little
Keyword(s):  
Natural Killer Cells ◽  
Acquired Immunodeficiency Syndrome ◽  
Cancer Recurrence ◽  
Cancer Surgery ◽  
The Other ◽  
Blood Transfusions ◽  
Suppressor T Lymphocytes ◽  
Acquired Immunodeficiency ◽  
Immunodeficiency Syndrome ◽  
Worse Prognosis

This collective review addresses the issue of transfusion-induced immunosuppression as it relates to patients undergoing cancer surgery. Patients receiving perioperative blood transfusions have a significantly worse prognosis than patients undergoing cancer surgery without a perioperative transfusion. It is thought that this is because transfusions produce a nonspecific immunosuppression by increasing the number and/or activity of suppressor T lymphocytes, decreasing the number of natural killer cells, and inducing anti-idiotypic antibodies. This risk, particularly when considered with the other risks of transfusion such as hepatitis or the acquired immunodeficiency syndrome (AIDS), suggests that criteria for transfusion of these patients should be stringent and related to an unequivocal need for replenishment of RBCs.

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