scholarly journals Decision letter: Striatal adenosine A2A receptor neurons control active-period sleep via parvalbumin neurons in external globus pallidus

2017 ◽  
Keyword(s):  
Globus Pallidus ◽  
Adenosine A2a Receptor ◽  
Active Period ◽  
A2a Receptor ◽  
Receptor Neurons ◽  
Adenosine A2a ◽  
Parvalbumin Neurons

scholarly journals Striatal adenosine A2A receptor neurons control active-period sleep via parvalbumin neurons in external globus pallidus

eLife ◽  
2017 ◽  
Vol 6 ◽  
Author(s):  
Xiang-Shan Yuan ◽  
Lu Wang ◽  
Hui Dong ◽  
Wei-Min Qu ◽  
Su-Rong Yang ◽  
...  
Keyword(s):  
Globus Pallidus ◽  
Sleep Disturbances ◽  
Nrem Sleep ◽  
Inhibitory Synapses ◽  
Active Period ◽  
Promoting Effect ◽  
A2a Receptors ◽  
A2a Receptor ◽  
Receptor Neurons ◽  
Adenosine A2a

Dysfunction of the striatum is frequently associated with sleep disturbances. However, its role in sleep-wake regulation has been paid little attention even though the striatum densely expresses adenosine A2A receptors (A2ARs), which are essential for adenosine-induced sleep. Here we showed that chemogenetic activation of A2AR neurons in specific subregions of the striatum induced a remarkable increase in non-rapid eye movement (NREM) sleep. Anatomical mapping and immunoelectron microscopy revealed that striatal A2AR neurons innervated the external globus pallidus (GPe) in a topographically organized manner and preferentially formed inhibitory synapses with GPe parvalbumin (PV) neurons. Moreover, lesions of GPe PV neurons abolished the sleep-promoting effect of striatal A2AR neurons. In addition, chemogenetic inhibition of striatal A2AR neurons led to a significant decrease of NREM sleep at active period, but not inactive period of mice. These findings reveal a prominent contribution of striatal A2AR neuron/GPe PV neuron circuit in sleep control.

Adenosine A2A receptor stimulation decreases GAT-1-mediated GABA uptake in the globus pallidus of the rat

2006 ◽  
Vol 51 (1) ◽  
pp. 154-159 ◽  
Author(s):  
Brenda Gonzalez ◽  
Francisco Paz ◽  
Leonor Florán ◽  
Jorge Aceves ◽  
David Erlij ◽  
...  
Keyword(s):  
Globus Pallidus ◽  
Adenosine A2a Receptor ◽  
Gaba Uptake ◽  
Receptor Stimulation ◽  
A2a Receptor ◽  
Adenosine A2a

Striatal adenosine A2A receptor neurons regulate sleep behavior

2017 ◽  
Vol 40 ◽  
pp. e359
Author(s):  
X.-S. Yuan ◽  
L. Wang ◽  
H. Dong ◽  
R.-L. Li ◽  
W.-M. Qu ◽  
...  
Keyword(s):  
Adenosine A2a Receptor ◽  
Sleep Behavior ◽  
A2a Receptor ◽  
Receptor Neurons ◽  
Adenosine A2a

Adenosine A2A Receptor Neurons in the Olfactory Bulb Mediate Odor-Guided Behaviors in Miceg

2021 ◽  
pp. 147590
Author(s):  
Xiao Sun ◽  
Lei Li ◽  
Hu-Yun-Long Zhang ◽  
Wei He ◽  
Dian-Ru Wang ◽  
...  
Keyword(s):  
Olfactory Bulb ◽  
Adenosine A2a Receptor ◽  
A2a Receptor ◽  
Receptor Neurons ◽  
Adenosine A2a
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