Toxic Alcohol Ingestion: A Case Report and Review of Management Pathways

Isolated perforation of gallbladder following trauma is very rare and is mainly caused due to distended gallbladder as a result of fasting or alcohol ingestion in normal patients. We report a case of gall bladder perforation caused due to squeeze injury.

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Authors' reply to Comment on Distinguishing between toxic alcohol ingestion vs alcoholic ketoacidosis

Clinical Toxicology ◽

10.1080/15563650.2021.1902534 ◽

2021 ◽

pp. 1-1

Author(s):

Emily T. Cohen ◽

Mark K. Su ◽

Rana Biary ◽

Robert S. Hoffman

Keyword(s):

Alcohol Ingestion ◽

Toxic Alcohol ◽

Alcoholic Ketoacidosis

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A Systematic Review of Ethanol and Fomepizole Use in Toxic Alcohol Ingestions

Emergency Medicine International ◽

10.1155/2013/638057 ◽

2013 ◽

Vol 2013 ◽

pp. 1-14 ◽

Cited By ~ 21

Author(s):

Lorri Beatty ◽

Robert Green ◽

Kirk Magee ◽

Peter Zed

Keyword(s):

Systematic Review ◽

Ethylene Glycol ◽

Data Extraction ◽

Alcohol Ingestion ◽

Data Synthesis ◽

Toxic Alcohol ◽

Study Selection ◽

Data Source ◽

Ethylene Glycol Intoxication ◽

Collection Form

Objectives. The optimal antidote for the treatment of ethylene glycol or methanol intoxication is not known. The objective of this systematic review is to describe all available data on the use of ethanol and fomepizole for methanol and ethylene glycol intoxication.Data Source. A systematic search of MEDLINE and EMBASE was conducted.Study Selection. Published studies involving the use of ethanol or fomepizole, or both, in adults who presented within 72 hours of toxic alcohol ingestion were included. Our search yielded a total of 145 studies for our analysis. There were no randomized controlled trials, and no head-to-head trials.Data Extraction. Variables were evaluated for all publications by one independent author using a standardized data collection form.Data Synthesis. 897 patients with toxic alcohol ingestion were identified. 720 (80.3%) were treated with ethanol (505 Me, 215 EG), 146 (16.3%) with fomepizole (81 Me, 65 EG), and 33 (3.7%) with both antidotes (18 Me, 15 EG). Mortality in patients treated with ethanol was 21.8% for Me and 18.1% for EG. In those administered fomepizole, mortality was 17.1% for Me and 4.1% for EG. Adverse events were uncommon.Conclusion. The data supporting the use of one antidote is inconclusive. Further investigation is warranted.

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Methanol and ethylene glycol poisoning: a case study and review of current literature

CJEM ◽

10.1017/s1481803500006035 ◽

2002 ◽

Vol 4 (01) ◽

pp. 34-40 ◽

Cited By ~ 13

Author(s):

William R. Henderson ◽

Jeffrey Brubacher

Keyword(s):

Ethylene Glycol ◽

Fatal Outcome ◽

Clinical Findings ◽

Alcohol Ingestion ◽

Toxic Alcohol ◽

Clinical Toxicity ◽

Ethanol Infusion ◽

Ethylene Glycol Poisoning ◽

Rule Out

ABSTRACTPoisoning is an uncommon but potentially fatal outcome of toxic alcohol ingestion. The toxic alcohols methanol, ethylene glycol and isopropyl alcohol are commonly found in household and commercial products. Because the toxic effects are caused by the metabolites of methanol and ethylene glycol rather than the agents themselves, there is often a substantial delay between ingestion and onset of clinical toxicity. Anion and osmolar gaps are often used for the diagnosis and exclusion of these sometimes subtle overdoses. The pitfalls of using these tests to rule out alcohol ingestion are reviewed. Ethanol infusion is the traditional therapy for such overdoses. In addition to the pathophysiology and clinical findings in poisoning, recent evidence for the use of fomepizole and adjuvant therapies is reviewed.

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