Development of Combined Genetic and Imaging Approaches for Differentiation of Cutaneous Malignant Melanoma and Benign Melanocytic Nevi

2016 ◽  
Vol 9 (3) ◽  
pp. 1-9
Author(s):  
S Abdalla ◽  
N Al-Aama
Keyword(s):  
Malignant Melanoma ◽  
Cutaneous Malignant Melanoma ◽  
Melanocytic Nevi ◽  
Benign Melanocytic Nevi

The alteration of microrna expression profiles in cutaneous malignant melanoma and benign melanocytic nevi

2021 ◽  
Vol 19 (4) ◽  
pp. 27-33
Author(s):  
Seseg Vitalievna Tsyrenzhapova ◽  
Roman Nikolaevich Belonogov ◽  
Ekaterina Yurievna Sergeeva ◽  
Tatyana Gennagievna Ruksha
Keyword(s):  
Malignant Melanoma ◽  
Expression Profiles ◽  
Cutaneous Malignant Melanoma ◽  
Microrna Expression ◽  
Melanocytic Nevi ◽  
Benign Melanocytic Nevi

Expression of Melan-A (MART1) in Benign Melanocytic Nevi and Primary Cutaneous Malignant Melanoma

1998 ◽  
Vol 22 (8) ◽  
pp. 976-982 ◽  
Author(s):  
Klaus J. Busam ◽  
Yao-Tseng Chen ◽  
Lloyd J. Old ◽  
Elisabeth Stockert ◽  
Kristin Iversen ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Cutaneous Malignant Melanoma ◽  
Primary Cutaneous Malignant Melanoma ◽  
Melanocytic Nevi ◽  
Benign Melanocytic Nevi

scholarly journals Evidence for differential expression of Notch receptors and their ligands in melanocytic nevi and cutaneous malignant melanoma

2005 ◽  
Vol 19 (2) ◽  
pp. 246-254 ◽  
Author(s):  
Daniela Massi ◽  
Francesca Tarantini ◽  
Alessandro Franchi ◽  
Milena Paglierani ◽  
Claudia Di Serio ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Differential Expression ◽  
Cutaneous Malignant Melanoma ◽  
Melanocytic Nevi ◽  
Notch Receptors

scholarly journals Immunohistochemical Study of Pepsinogen C Expression in Cutaneous Malignant Melanoma: Association with Clinicopathological Parameters

2001 ◽  
Vol 16 (4) ◽  
pp. 240-244 ◽  
Author(s):  
I. Quintela ◽  
F. Vizoso1 ◽  
C. Serra ◽  
L.O. González1 ◽  
R. Fernández1 ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Tumor Stage ◽  
Cutaneous Malignant Melanoma ◽  
Clinicopathological Parameters ◽  
Benign Lesions ◽  
Melanocytic Nevi ◽  
Pepsinogen C ◽  
Level Of Invasion ◽  
Positive Immunostaining ◽  
Malignant Cutaneous Melanoma

Background The aim of this study was to evaluate the pepsinogen C expression in malignant cutaneous melanomas and analyze its possible relationship to clinical and pathological parameters. Pepsinogen C is an aspartyl proteinase primarily involved in the digestion of proteins in the stomach and represents one of the main androgen-inducible proteins in breast cancer cells. Method Tumoral pepsinogen C expression was retrospectively analyzed in 35 paraffin-embedded tissues from patients with primary malignant cutaneous melanoma and in 10 samples from 10 benign lesions (4 dermal melanocytic nevi, 4 compound melanocytic nevi and 2 dysplastic melanocytic nevi), using immunohistochemical methods. Results The benign lesions were consistently negative for pepsinogen C, whereas 20 of the 35 malignant melanomas (57%) showed positive immunostaining for pepsinogen C. The percentage of pepsinogen C-positive tumors was significantly higher in men than in women (p=0.01) and in epithelioid melanomas than in fusocellular or mixed type melanomas (p=0.003). In addition, the percentage of pepsinogen-C positive tumors was positively and significantly correlated with lesion thickness (p=0.003), Clark's level of invasion (p=0.028) and tumor stage (p<0.001). Conclusion Pepsinogen C could be a new prognosticator of unfavorable outcome in cutaneous malignant melanoma.

Epidemiologic evidence for the role of melanocytic nevi as risk markers and direct precursors of cutaneous malignant melanoma

1992 ◽  
Vol 26 (6) ◽  
pp. 920-926 ◽  
Author(s):  
Sabine Krüger ◽  
Claus Garbe ◽  
Petra Büttner ◽  
Rudolf Stadler ◽  
Irene Guggenmoos-Holzmann ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Cutaneous Malignant Melanoma ◽  
Risk Markers ◽  
Melanocytic Nevi ◽  
Epidemiologic Evidence
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