Mekanisme Kejadian Dermatitis Kontak Iritan Akibat Paparan Buah Nanas (Ananas Comosus)

Irritant contact dermatitis is the skin's response to contact with various exposures to substances such as biological, chemical and physical. The occurrence of DKI can be influenced by endogenous and exogenous factors. Exogenous factors such as exposure to substances from the surrounding environment and endogenous factors such as skin defense function and the presence of a previous history of dermatitis such as atopic dermatitis. This literature review aims to understand the mechanism of the occurrence of irritant contact dermatitis due to exposure to pineapple(Ananas comosus)especially in workers and prevention. The study was conducted by collecting a number of books, research articles and scientific journals that deal with the mechanism of the occurrence of irritant contact dermatitis due to exposure to pineapple(Ananas comosus). Literature review has been conducted in Julì 2019. Pineapple or Ananas comosus is a member of the bromeliad family and is known to be the cause of irritant dermatitis and stomatitis. Pineapple extraction contains a number of proteolytic enzymes known as bromelain, which are also chemical and physical irritants including citric acid and calcium oxalate. Therefore, pineapple fruit can be one of the causes of irritant contact dermatitis. This mechanism starts from mild exposure to continuously causing barrier distrubsi which causes the activation of cytokines and T lymphocytes that cause symptoms in the form of inflammation and lesions on the skin

Causes of irritant contact dermatitis after occupational skin exposure: a systematic review

Purpose Irritant contact dermatitis (ICD) is a major cause of occupational disease. The aim was to review the relation between exposure to occupational irritants and ICD and the prognosis of ICD. Methods Through a systematic search, 1516 titles were identified, and 48 studies were included in the systematic review. Results We found that the evidence for an association between ICD and occupational irritants was strong for wet work, moderate for detergents and non-alcoholic disinfectants, and strong for a combination. The highest quality studies provided limited evidence for an association with use of occlusive gloves without other exposures and moderate evidence with simultaneous exposure to other wet work irritants. The evidence for an association between minor ICD and exposure to metalworking fluids was moderate. Regarding mechanical exposures, the literature was scarce and the evidence limited. We found that the prognosis for complete healing of ICD is poor, but improves after decrease of exposure through change of occupation or work tasks. There was no substantial evidence for an influence of gender, age, or household exposures. Inclusion of atopic dermatitis in the analysis did not alter the risk of ICD. Studies were at risk of bias, mainly due to selection and misclassification of exposure and outcome. This may have attenuated the results. Conclusion This review reports strong evidence for an association between ICD and a combination of exposure to wet work and non-alcoholic disinfectants, moderate for metalworking fluids, limited for mechanical and glove exposure, and a strong evidence for a poor prognosis of ICD.