Mekanisme Kejadian Dermatitis Kontak Iritan Akibat Paparan Buah Nanas (Ananas Comosus)

Irritant contact dermatitis is the skin's response to contact with various exposures to substances such as biological, chemical and physical. The occurrence of DKI can be influenced by endogenous and exogenous factors. Exogenous factors such as exposure to substances from the surrounding environment and endogenous factors such as skin defense function and the presence of a previous history of dermatitis such as atopic dermatitis. This literature review aims to understand the mechanism of the occurrence of irritant contact dermatitis due to exposure to pineapple(Ananas comosus)especially in workers and prevention. The study was conducted by collecting a number of books, research articles and scientific journals that deal with the mechanism of the occurrence of irritant contact dermatitis due to exposure to pineapple(Ananas comosus). Literature review has been conducted in Julì 2019. Pineapple or Ananas comosus is a member of the bromeliad family and is known to be the cause of irritant dermatitis and stomatitis. Pineapple extraction contains a number of proteolytic enzymes known as bromelain, which are also chemical and physical irritants including citric acid and calcium oxalate. Therefore, pineapple fruit can be one of the causes of irritant contact dermatitis. This mechanism starts from mild exposure to continuously causing barrier distrubsi which causes the activation of cytokines and T lymphocytes that cause symptoms in the form of inflammation and lesions on the skin