membrane cofactor protein
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2021 ◽  
pp. 239936932110626
Author(s):  
Marina Almenara Tejederas ◽  
Laura De la Torre Corona ◽  
Fabiola Alonso García ◽  
María Ángeles Rodríguez Pérez ◽  
Rocío Cabrera Pérez ◽  
...  

The most frequent cause of atypical hemolytic uremic syndrome (aHUS) is defective regulation of complement activation because of genetic anomalies. We present the case of 53-year-old man with a kidney transplant and stabilized kidney function (creatinine 2.5 mg/dL; proteinuria 0.4 g/24 h) with mycophenolate/tacrolimus/prednisone who was diagnosed of Thrombotic Microangiopathy (TMA). This diagnosis was associated with creatinine and proteinuria rise (3 mg/dL; 2.4 g/24 h) and a new monoclonal IgA/lambda component. Renal biopsy showed membranoproliferative glomerulonephritis; a pathogenic variant in the Membrane cofactor protein (MCP) gene with a polymorphism ggaac, typically associated to secondary aHUS, was identified. We suspected that immunoglobulin could be acting as a trigger for TMA in a genetically susceptible patient, so “clone-directed” therapy with bortezomib and dexamethasone was initiated.



2021 ◽  
Vol 72 ◽  
pp. 126-134
Author(s):  
M Kathryn Liszewski ◽  
John P Atkinson




3 Biotech ◽  
2020 ◽  
Vol 10 (3) ◽  
Author(s):  
Heasun Lee ◽  
In-sul Hwang ◽  
Bala Murali Krishna Vasamsetti ◽  
Harikrishna Reddy Rallabandi ◽  
Mi-Ryung Park ◽  
...  


2020 ◽  
Author(s):  


2019 ◽  
Vol 19 ◽  
pp. 100652
Author(s):  
Maria G. Detsika ◽  
Eleni D. Myrtsi ◽  
Sofia D. Koulocheri ◽  
Serkos A. Haroutounian ◽  
Elias A. Lianos ◽  
...  


2019 ◽  
Vol 51 (6) ◽  
pp. 2043-2050
Author(s):  
Imran Ullah ◽  
Ran Lee ◽  
Keon Bong Oh ◽  
Youngim Kim ◽  
Jae-Seok Woo ◽  
...  


2018 ◽  
pp. 271-281
Author(s):  
M. Kathryn Liszewski ◽  
John P. Atkinson


2017 ◽  
Vol 32 (3) ◽  
pp. 73-79 ◽  
Author(s):  
Gunsup Lee ◽  
Sang Hyoun Park ◽  
Haesun Lee ◽  
Soo-Jeong Ji ◽  
Joo Yung Lee ◽  
...  


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