Experience in creation of database (registry) of patients with posttraumatic cicatrical biliary strictures. First results

Aim. To demonstrate the first results of the work on database created to assess long-term results of treatment of patients with posttraumatic biliary strictures and to develop a unified approach to the management of these patients.Materials and methods. “The register of patients with post-traumatic strictures of the bile ducts in Russia and the CIS countries” was created in 2016. It is a software for a computer that provides the opportunity for detailed registration and data analysis of a large number of patients.Results. From 2016 to 2021, the data of 132 patients were entered into the register. Long-term results were traced in 49 (60.5%) patients with the minimum and maximum follow-up periods of 3 and 44 months.Conclusion. The first registry results demonstrate its capabilities in generalization and analysis of treatment data for the patients with cicatrical posttraumatic biliary strictures. It also showed the necessity for wider participation of different specialists in work of database.

Machine Perfusion in Liver Transplantation: A Systematic Review and Meta-Analysis

<b><i>Background:</i></b> Liver transplantation (LTx) is the only treatment option for patients with end-stage liver disease. Novel organ preservation techniques such as hypothermic machine perfusion (HMP) or normothermic machine perfusion (NMP) are under investigation in order to improve organ quality from extended criteria donors and donors after circulatory death. The aim of this study was to systematically review the literature reporting LTx outcomes using NMP or HMP compared to static cold storage (SCS). <b><i>Methods:</i></b> The following data were retrieved: graft primary nonfunction rate, early allograft dysfunction (EAD) rate, biliary complication rate, and 12-month graft and patient survival. A total of 15 studies were included (6 NMP and 9 HMP studies), and meta-analysis was performed only for HMP studies because NMP had considerable differences. <b><i>Results:</i></b> The systematic review showed the potential of NMP to reduce graft injury and lower the liver graft discard rate. The performed quantitative analyses showed that the use of HMP reduces the rate of EAD (odds ratio [OR] 0.51; 95% confidence interval [CI] 0.34–0.76; <i>p</i> = 0.001; <i>I</i>² = 0%) and non-anastomotic biliary strictures (OR 0.34; 95% CI 0.17–0.67; <i>p</i> = 0.002; <i>I</i>² = 0%) compared to SCS. <b><i>Conclusion:</i></b> Our systematic review and meta-analysis revealed that the use of HMP reduces the rate of EAD and non-anastomotic biliary strictures compared to SCS.