An efficient one-pot synthesis of the cis-pyridylimine palladium (II) complexes is reported. The compo- sition and structure were proved by NMR, IR, X-ray, and elemental analysis. The monoamine oxidase inhibition activity of synthesized complexes, including six complexes previously unknown, were inves- tigated on native mouse brains. Some of the synthesized compounds: cis-dichlorido-2,6-dimethyl-N- ((pyridin-2-yl)methylene)anilinepalladium(II), cis-dichlorido-4-nitro-N-((pyridin-2-yl)methylene)- anilinepalladium(II), and cis-dibromido-2,6-di(propan-2-yl)-N-((pyridin-2-yl)methylene)aniline- palladium(II) inhibited monoamine oxidase with moderate activity (IC50: 13.09–17.66 μМ). None of the studied compounds showed cytotoxic activity against HEK-293 cell line (human kidney embryonic cells). Acute systemic toxicity assay, that is conducted by intraperitoneal injection of cis-dichlorido-4- nitro-N-((pyridin-2-yl)methylene)anilinepalladium(II) indicated low toxicity (LD50> 5000 mg / kg) for outbred stocks mice. Bioavailability was assessed by logP’s measurement.
Development and butyrylcholinesterase/monoamine oxidase inhibition potential of PVA-Moringa oleifera developed nanofibers