Abstract. Uncertainty, fear to harm the patient, discomfort handling the discussion and lack of time are the most cited barriers to prognostic disclosure. Physicians can be reassured that patients desire the truth about prognosis and can manage the discussion without harm, including the uncertainty of the information, if approached in a sensitive manner. Conversational guides could provide support in preparing such difficult conversations. Communicating ’with realism and hope’ is possible, and anxiety is normal for both patients and clinicians during prognostic disclosure. As a clinician pointed out: ’I had asked a mentor once if it ever got easier. – No. But you get better at it.’