Tunable Heteroaromatic Azoline thioethers (HAT) for Cysteine Profiling

Here we report a new series of hydrolytically stable chemotype Heteroaromatic Azoline Thioethers (HAT) to achieve highly selective, rapid, and efficient covalent labeling of cysteine under physiological conditions. Although the...

A novel 18F-labeled clickable substrate for targeted imaging of SNAP-tag expressing cells by PET in vivo

Bioorthogonal covalent labeling with self-labeling enzymes like SNAP-tag bears a high potential for specific targeting of cells for imaging in vitro and in vivo. To this end, fluorescent SNAP substrates...