inhibitor specificity
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Abstract 1398: Impact of proteasome inhibitor specificity and efficacy on apoptosis induction by combination with ABT-199

2021 ◽  
Author(s):  
Sandra Weller ◽  
Benjamin Schaefer ◽  
Tobias Beigl ◽  
Kathrin Böpple ◽  
Walter E. Aulitzky ◽  
...  
Keyword(s):  
Proteasome Inhibitor ◽  
Apoptosis Induction ◽  
Inhibitor Specificity

Effect of protease inhibitor specificity on dentin matrix properties

2020 ◽  
Vol 109 ◽  
pp. 103861
Author(s):  
Arwa Bafail ◽  
Marcela Rocha Carrilho ◽  
Anil Kishen ◽  
Anuradha Prakki
Keyword(s):  
Protease Inhibitor ◽  
Inhibitor Specificity ◽  
Matrix Properties ◽  
Dentin Matrix

scholarly journals Methods to validate Hsp90 inhibitor specificity, to identify off-target effects, and to rethink approaches for further clinical development

2018 ◽  
Vol 23 (4) ◽  
pp. 467-482 ◽  
Author(s):  
Len Neckers ◽  
Brian Blagg ◽  
Timothy Haystead ◽  
Jane B. Trepel ◽  
Luke Whitesell ◽  
...  
Keyword(s):  
Hsp90 Inhibitor ◽  
Clinical Development ◽  
Inhibitor Specificity ◽  
Target Effects

scholarly journals X-ray crystal structure of plasmin with tranexamic acid–derived active site inhibitors

2017 ◽  
Vol 1 (12) ◽  
pp. 766-771 ◽  
Author(s):  
Ruby H. P. Law ◽  
Guojie Wu ◽  
Eleanor W. W. Leung ◽  
Koushi Hidaka ◽  
Adam J. Quek ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Tranexamic Acid ◽  
Active Site ◽  
Molecular Basis ◽  
Structural Alignment ◽  
Inhibitor Specificity ◽  
X Ray ◽  
Key Points ◽  
Alignment Analysis

Key Points Plasmin YO inhibitors form extensive interactions with the prime sites, thus anchoring the TXA moiety inside the catalytic pocket. Structural alignment analysis with urokinase and kallikrein gives insights into the molecular basis of the YO inhibitor specificity.

Substrate and inhibitor specificity of kynurenine monooxygenase from Cytophaga hutchinsonii

2017 ◽  
Vol 27 (8) ◽  
pp. 1705-1708 ◽  
Author(s):  
Robert S. Phillips ◽  
Andrew D. Anderson ◽  
Harvey G. Gentry ◽  
Osman F. Güner ◽  
J. Phillip Bowen
Keyword(s):  
Inhibitor Specificity ◽  
Cytophaga Hutchinsonii

scholarly journals Substrate and Inhibitor Specificity of the Plasmodium berghei Equilibrative Nucleoside Transporter Type 1

2016 ◽  
Vol 89 (6) ◽  
pp. 678-685 ◽  
Author(s):  
Avish Arora ◽  
Roman Deniskin ◽  
Yvett Sosa ◽  
Sita Nirupama Nishtala ◽  
Philipp P. Henrich ◽  
...  
Keyword(s):  
Plasmodium Berghei ◽  
Nucleoside Transporter ◽  
Inhibitor Specificity ◽  
Equilibrative Nucleoside Transporter
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