Electrochemical borylation of carboxylic acids

A simple electrochemically mediated method for the conversion of alkyl carboxylic acids to their borylated congeners is presented. This protocol features an undivided cell setup with inexpensive carbon-based electrodes and exhibits a broad substrate scope and scalability in both flow and batch reactors. The use of this method in challenging contexts is exemplified with a modular formal synthesis of jawsamycin, a natural product harboring five cyclopropane rings.

Electrochemical Borylation of Carboxylic Acids

A simple electrochemically mediated method for the conversion of alkyl carboxylic acids to their borylated congeners is presented. This protocol features an undivided cell setup with inexpensive carbon-based electrodes and exhibits a broad substrate scope and scalability in both flow and batch reactors. The use of this method in challenging contexts is exemplified with a modular formal synthesis of jawsamycin, a natural product harboring five cyclopropane rings.

Electrochemical Borylation of Carboxylic Acids

A simple electrochemically mediated method for the conversion of alkyl carboxylic acids to their borylated congeners is presented. This protocol features an undivided cell setup with inexpensive carbon-based electrodes and exhibits a broad substrate scope and scalability in both flow and batch reactors. The use of this method in challenging contexts is exemplified with a modular formal synthesis of jawsamycin, a natural product harboring five cyclopropane rings.

Organocatalyzed Photoelectrochemical C−H Amination of Arenes

Catalytic C–H/N–H cross-coupling is considered an ideal strategy for accessing anilines and derivatives, but its synthetic execution remains extremely challenging, especially when the exclusion of external oxidants is desired. Report herein is a photoelectrochemical method for the preparation of anilides through C–H/N–H coupling of arenes and carbamates, which employs DDQ as a molecular catalyst. The reactions are conducted in a simple undivided cell with visible-light irradiation and without any need for external chemical oxidants. In addition, the reactions employ arenes as the limiting agent, and are compatible with benzene and halogenated benzenes

Organocatalyzed Photoelectrochemical C−H Amination of Arenes

Catalytic C–H/N–H cross-coupling is considered an ideal strategy for accessing anilines and derivatives, but its synthetic execution remains extremely challenging, especially when the exclusion of external oxidants is desired. Report herein is a photoelectrochemical method for the preparation of anilides through C–H/N–H coupling of arenes and carbamates, which employs DDQ as a molecular catalyst. The reactions are conducted in a simple undivided cell with visible-light irradiation and without any need for external chemical oxidants. In addition, the reactions employ arenes as the limiting agent, and are compatible with benzene and halogenated benzenes

Electrochemical sulfonylation of enamides with sodium sulfinates to access β-amidovinyl sulfones

The electrochemical sulfonylation of enamides with sodium sulfinates in an undivided cell under catalyst- and exogenous redox reagent-free conditions was developed to access a variety of β-amidovinyl sulfones.

Electrochemical Oxidative Cyclization of N-Allylcarboxamides: Efficient Synthesis of Halogenated Oxazolines

Herein, we reported an efficient and sustainable intramolecular electrochemical cyclization of N-allylcarboxamides for the synthesis of various halogenated oxazolines. This method was conducted in a simple undivided cell by employing...

Organocatalytic electrochemical amination of benzylic C–H bonds

An organocatalytic site-selective electrochemical method for the benzylic C–H amination reactions of alkylarenes with azoles through hydrogen evolution has been developed. The protocol proceeds in an undivided cell under mild...

Nickel-Catalyzed Electrochemical Reductive Relay Cross-Coupling of Alkyl Halides with Alkyl Carboxylic Acids

A highly regioselective Ni-catalyzed electrochemical (undivided cell) reductive relay cross-coupling between alkyl carbox-ylic acids and alkyl bromides has been developed. This strategy allows the direct acylation of benzylic C(sp3)–H bonds...