Let E represent any of the spaces M u , C ϑ ( ϑ = { b , b p , r } ) , and L q ( 0 < q < ∞ ) of bounded, ϑ -convergent, and q-absolutely summable double sequences, respectively, and E ˜ be the domain of the four-dimensional (4D) infinite sequential band matrix B ( r ˜ , s ˜ , t ˜ , u ˜ ) in the double sequence space E, where r ˜ = ( r m ) m = 0 ∞ , s ˜ = ( s m ) m = 0 ∞ , t ˜ = ( t n ) n = 0 ∞ , and u ˜ = ( u n ) n = 0 ∞ are given sequences of real numbers in the set c ∖ c 0 . In this paper, we investigate the double sequence spaces E ˜ . First, we determine some topological properties and prove several inclusion relations under some strict conditions. Then, we examine α -, β ( ϑ ) -, and γ -duals of E ˜ . Finally, we characterize some new classes of 4D matrix mappings related to our new double sequence spaces and conclude the paper with some significant consequences.