Significance of the cronobiological factors in a spa treatment of gynaecological patients

In the article the outcomes of the research of efficiency of complex SPA treatment of the patients with chronic inflammatory diseases of organs of the small pelvis in various seasons of the year in conditions of humid subtropics are indicated. The dynamics ofa psycho-emotional condition, vegetative reactivity, condition of the protective-adapting mechanisms of the gomeostasis are investigated, depending on a kind of applied SPA treatment (hydrogen sulfide or iodine bromide)? In cool and warm periods of a year. The recommendations for differentiated rehabilitation treatment of patients with valiants of clinical process of chronic inflammatory diseases of organs of the small pelvis and complications, accompanying them, in conditions of humid subtropics are represented.

Polycentric binding in complexes of trimethylamine-N-oxide with dihalogens

Dihalogens readily interact with trimethylamine-N-oxide under ambient conditions. Stable 1 : 1 adducts were obtained in a case of iodine chloride and iodine bromide. Formally monodentate ligands are bound in a polycentric manner.

Electrophilic ipso-Halocyclization of N-Phenyl-N-triflylpropiolamides Leading to 8-Halo-1-azaspiro[4.5]deca-3,6,9-trien-2-ones

N-Phenyl-N-triflylpropiolamides react with iodine chloride or iodine bromide by an intramolecular electrophilic ipso-halocyclization/nucleophilic halide addition sequence to furnish cyclohexadiene-spiro-γ-lactams. These products can undergo cleavage of the amide bond with primary amines and of the N–Cspiro bond with secondary amines, leading to N-alkyl-2-iodo-3-phenylacrylamides and N-(4-halophenyl)-2-iodo-3-(2-triflylamino)phenylacrylamides, respectively.