New enterprises for products in prepackages with fixed content always use sampling inspection to make sure the accuracy of the net quantity of their products according to JJF 1070-2005 “Rules of Metrological Testing for Net Quantity of Products in Prepackages with Fixed Content”, but this sampling inspection plan is expensive. The theoretical basis of the variable sampling plan in JJF 1070 was analyzed first. Then based on ISO 3951-1, the variable acceptance standard, a new sampling plan for products in prepackages with fixed content was developed, and it’s operation characteristic curve was drawn. Taking one company in Jinhua city of Zhejiang province of China as an example, a comparative analysis for the practical application of these two sampling plans was carried out. Under the premise that the sampling plan’s discrimination power was unchanged, the results showed that the acceptance effects of two sampling plans waere almost the same, while the reduction of sample size for the new one was 44%, the inspection time and cost were all reduced.