Infrascapular granular cell tumor: an unusual entity

Granular cell tumor (GCT) is an uncommon soft tissue tumor of schwannian origin frequent among women and blacks between the second and sixth decades of life. The common location of GCT is the oral cavity, but it can also occur at other sites. Cutaneous lesions constitute about 30% of cases and are characterized by a gradually developing nodular lesion. Due to their subtle clinical appearance and symptomatology, GCTs are often misdiagnosed. We report a case of subcutaneous GCT in the infrascapular region in a 40 year old female which mimicked granular cell dermatofibroma on histopathology. Although a rare entity, Granular cell tumor should be considered in the differential diagnosis of the subcutaneous soft tissue tumours and require histopathological examination along with immunohistochemistry to confirm the diagnosis and differentiate them from other benign and malignant tumors showing granular cell change.

The Unique Simultaneous Occurrence of Granular Cell Tumor, Gastrointestinal Stromal Tumor, and Gastric Adenocarcinoma

Granular cell tumors are generally benign oncocytoid lesions of schwannian origin that are often incidental findings in many locations. Gastrointestinal stromal tumors occur in older adults and express the c-Kit protein (CD117). Both of these tumors have been described in association with many other entities; however, they have never been reported to occur jointly. This report is prompted by the simultaneous appearance of 2 granular cell tumors, a gastrointestinal stromal tumor, and a gastric adenocarcinoma in a 65-year-old woman with a history of breast carcinoma and granular cell tumor. To our knowledge, this is the first case report of these tumors occurring simultaneously.

Blue Nevus of the Endocervix. A Study of Five Cases

The pathologic and immunohistochemical features of 5 cases of blue nevus of the endocervix are presented: 4 of them were studied ultrastructurally. The lesions were incidentaly discovered at microscopic examination and showed pigmented dendritic cells in the cervical stroma. Immunocytochemical examination showed all cases to be positive for S-100 protein. Ultrastructurally they contained melanosomes, were surrounded by a basement membrane, and displayed occasional desmosome-like devices. Histogenesis is discussed, and support for a schwannian origin is presented.