The Unique Simultaneous Occurrence of Granular Cell Tumor, Gastrointestinal Stromal Tumor, and Gastric Adenocarcinoma

2005 ◽  
Vol 129 (5) ◽  
pp. e121-e123
Author(s):  
Joseph L. Sailors ◽  
Samuel W. French
Keyword(s):  
Gastrointestinal Stromal Tumor ◽  
Gastric Adenocarcinoma ◽  
Granular Cell Tumor ◽  
Granular Cell ◽  
Cell Tumor ◽  
Stromal Tumor ◽  
Simultaneous Occurrence ◽  
First Case ◽  
History Of ◽  
Schwannian Origin

Abstract Granular cell tumors are generally benign oncocytoid lesions of schwannian origin that are often incidental findings in many locations. Gastrointestinal stromal tumors occur in older adults and express the c-Kit protein (CD117). Both of these tumors have been described in association with many other entities; however, they have never been reported to occur jointly. This report is prompted by the simultaneous appearance of 2 granular cell tumors, a gastrointestinal stromal tumor, and a gastric adenocarcinoma in a 65-year-old woman with a history of breast carcinoma and granular cell tumor. To our knowledge, this is the first case report of these tumors occurring simultaneously.

scholarly journals Concomitant Gastrointestinal Stromal Tumor of the Stomach and Gastric Adenocarcinoma in a Patient with Billroth 2 Resection

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Federico Sista ◽  
Valentina Abruzzese ◽  
Mario Schietroma ◽  
Gianfranco Amicucci
Keyword(s):  
Gastrointestinal Stromal Tumor ◽  
Gastric Adenocarcinoma ◽  
Gastric Resection ◽  
Stromal Tumor ◽  
Simultaneous Occurrence ◽  
Review Of The Literature ◽  
Billroth Ii ◽  
First Case ◽  
Mesenchymal Neoplasm ◽  
S 100

Background. With this study we focus on the etiopathogenesis and on the therapy of the simultaneous occurrence of Gastric gastrointestinal stromal tumor (gGIST) and adenocarcinoma of the stomach in a patient with Billroth II gastric resection (BIIGR). We report the first case of this event and a review of the literature.Methods. A 70-year-old man with a BIIGR, affected by adenocarcinoma of the stomach, was successfully treated with total gastrectomy. The histological examination showed a gastric adenocarcinoma with a synchronous GIST sized 2 cm and S-100, CD117, and CD34 positive. The mutation of PDGFR gene was detected.Discussion. This tumor is a rare mesenchymal neoplasm of the gastrointestinal tract. Few cases of synchronous gastric adenocarcinoma and GIST are observed in the literature and no case in patients with BIIGR. Various hypotheses have been proposed to explain this occurrence. It is frequently attributed to Metallothioneins genes mutations or embryological abnormalities, but this has not been proven yet. We suggest a hypothesis about the etiopathogenesis of this event in a BIIGR patient.Conclusion. GIST may occur synchronously with gastric adenocarcinoma. This simultaneous occurrence needs more studies to be proven. The study of Cajal cells’ proliferation signalling is crucial to demonstrate our hypotesis.

Colocalized Granular Cell Tumor and Infiltrating Ductal Carcinoma of the Breast

2002 ◽  
Vol 126 (6) ◽  
pp. 731-733 ◽  
Author(s):  
Hikmat Al-Ahmadie ◽  
Per-Olof Hasselgren ◽  
Rawia Yassin ◽  
George Mutema
Keyword(s):  
Invasive Ductal Carcinoma ◽  
Granular Cell Tumor ◽  
Ductal Carcinoma ◽  
Granular Cell ◽  
Cell Tumor ◽  
Palpable Mass ◽  
First Case ◽  
History Of ◽  
Well Differentiated ◽  
The Right

Abstract A 57-year-old woman presented with a 2-year history of a palpable mass in the upper inner quadrant of the right breast. A 1.1-cm, poorly circumscribed, firm tumor nodule was noted, consisting of 2 histologically distinct lesions in the same location, with some areas showing purely well-differentiated invasive ductal carcinoma and others composed of granular cell tumor. In 1 area, the 2 tumors collided and infiltrated each other. The invasive ductal carcinoma was admixed with ductal carcinoma in situ of solid and cribriform types. To our knowledge, this is the first case report demonstrating colocalization of these 2 neoplasms, which raises questions regarding causal relationship. We also review the literature on granular cell tumor of the breast.

scholarly journals Subsequent Development of Desmoid Tumor after a Resected Gastrointestinal Stromal Tumor

2018 ◽  
Vol 2018 ◽  
pp. 1-5
Author(s):  
Areen Abdulelah Murshid ◽  
Hatim Q. Al-Maghraby
Keyword(s):  
Gastrointestinal Stromal Tumor ◽  
Desmoid Tumor ◽  
Case Reports ◽  
Previous History ◽  
Subsequent Development ◽  
Stromal Tumor ◽  
Desmoid Tumors ◽  
Mesenchymal Tumors ◽  
First Case ◽  
History Of

Desmoid tumors (deep fibromatosis) of the mesentery are rare mesenchymal tumors. They are often misdiagnosed, especially with a previous history of resection for gastrointestinal stromal tumor (GIST). Immunohistochemistry can help differentiate between these two tumors. In this article, we present a case we had encountered: a Desmoid tumor developing in a patient with a history of GIST 3 years ago. It is the first case of GIST with subsequent development of Desmoid tumor to be reported in Saudi Arabia. We discuss the two entities of Desmoid tumor and GIST by comparing their definitions, clinical presentations, histological features, immunohistochemistry stains, molecular pathogenesis, prognosis, and treatment. We also discuss the relationship between GIST and the subsequent development of Desmoid tumors and compare our case with case reports in literature.

scholarly journals Preoperative diagnosis of a mediastinal granular cell tumor by EUS-FNA : A case report and review of the literature

CytoJournal ◽  
2005 ◽  
Vol 2 ◽  
pp. 8 ◽  
Author(s):  
Sarah M Bean ◽  
Mohamad A Eloubeidi ◽  
Isam A Eltoum ◽  
Robert J Cerfolio ◽  
Darshana N Jhala
Keyword(s):  
Case Report ◽  
Preoperative Diagnosis ◽  
Granular Cell Tumor ◽  
English Literature ◽  
Granular Cell ◽  
Needle Aspiration ◽  
Cell Tumor ◽  
Prior History ◽  
Cell Block ◽  
First Case

We report the first case of a posterior mediastinal granular cell tumor initially diagnosed on cytologic material obtained via endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) in a 51-year-old male with a prior history of colon cancer. Aspirates obtained were cellular and composed of polygonal cells with abundant granular cytoplasm and small, round dark nuclei. An immunoperoxidase stain performed on the cell block for antibodies to S-100 protein showed strong, diffuse staining of the cytoplasmic granules. Electron microscopy performed on the cell block revealed numerous cytoplasmic lysosomes. This is the first case report in the English literature of a definitive preoperative diagnosis of a mediastinal granular cell tumor utilizing material obtained via EUS-FNA.

scholarly journals A Rare Case of a Metastatic Malignant Abrikossoff Tumor

2021 ◽  
pp. 1868-1875
Author(s):  
Mohamed Tayeb Salaouatchi ◽  
Sandra De Breucker ◽  
Héloise Rouvière ◽  
Véronique Lesage ◽  
Laureen Jeanne Armande Rocq ◽  
...  
Keyword(s):  
Granular Cell Tumor ◽  
Soft Tissues ◽  
Granular Cell ◽  
Cell Tumor ◽  
Benign Tumors ◽  
Large Size ◽  
Positron Emission ◽  
History Of ◽  
Malignant Granular Cell Tumor ◽  
Malignant And Benign Tumors

Abrikossoff tumor, also called granular cell tumor (GCT), is a neoplasm of the soft tissues which is most commonly a solitary, painless, and benign tumor. However, 2% of Abrikossoff tumors can be malignant. We report here the case of a 75-year-old male who presented a local recurrence of Abrikossoff tumor of the left thigh. The anatomopathological analysis concluded to a malignant GCT, and the F-18 fluorodeoxyglucose positron emission tomography showed multiple lesions in the lymph nodes and bones. The potential conversion to malignancy should alert practitioners because of the extremely poor prognosis. The diagnosis of malignant granular cell tumor should be based on a bundle of clinical and histological features and not solely on histologic features because of the challenging distinction between malignant and benign tumors due to the lack of well-defined criteria for the diagnosis of malignancy. Large size and recurrence are the most important clinical features predicting malignant behavior. Patients with a history of Abrikossoff tumor should be followed closely to monitor recurrence and malignant transformation. The apparent originality of our observation – which could lie in the evolution of a GCT tumor, initially considered as benign, to a malignant form – has to be challenged regarding the issue of classifying some cases according to the classical “benign” and “malignant” dichotomy.

scholarly journals Granular Cell Tumor Presenting as a Tracheal Mass in a 17-year-old Female

2008 ◽  
Vol 23 (1) ◽  
pp. 39-40
Author(s):  
Jose M. Carnate ◽  
Audie G. Silva
Keyword(s):  
Tumor Cells ◽  
Granular Cell Tumor ◽  
S100 Protein ◽  
Granular Cell ◽  
Surgical Excision ◽  
Cell Tumor ◽  
Granular Cytoplasm ◽  
History Of ◽  
Infiltrative Growth Pattern ◽  
One Year

Granular cell tumors involving the trachea are rare. We present the case of a seventeen year old female with a one year history of gradually worsening dyspnea necessitating a tracheotomy. A suprastomal intraluminal tracheal mass was excised. Histologic sections (Figure 1) show a poorly circumscribed neoplasm infiltrating through the tracheal cartilage. It is composed of polygonal to somewhat elongated tumor cells that have small, dark nuclei. The cytoplasm is ample, eosinophilic and strikingly granular in quality. The cell borders are ill-defined creating a `syncytial’ pattern of dark nuclei scattered in a sea of granular cytoplasm. The diagnosis was a granular cell tumor. Immunohistochemistry (Figure 2) revealed strong, diffuse cytoplasmic positivity for S100 protein, attesting to its neural crest histogenesis. The infiltrative growth pattern may momentarily raise the question of malignancy but this is dispelled by awareness that infiltration is the natural history for all granular cell tumors, benign or malignant. Histologically, malignancy is diagnosed if three or more of the following are present: necrosis, spindling of tumor cells, vesicular nuclei with large nucleoli, greater than 2 mitoses per ten high power fields, high nucleus-to-cytoplasm ratio and nuclear pleomorphism. None was present in our case. Surgical excision remains the mainstay of treatment.

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