Continuity of the value function for deterministic optimal impulse control with terminal state constraint

Deterministic optimal impulse control problem with terminal state constraint is considered. Due to the appearance of the terminal state constraint, the value function might be discontinuous in general. The main contribution of this paper is the introduction of an intrinsic condition under which the value function is proved to be continuous. Then by a Bellman dynamic programming principle, the corresponding Hamilton-Jacobi-Bellman type quasi-variational inequality (QVI, for short) is derived. The value function is proved to be a viscosity solution to such a QVI. The issue of whether the value function is characterized as the unique viscosity solution to this QVI is carefully addressed and the answer is left open challengingly.

Experience in the use of magnetic resonance imaging in the diagnosis of professional myofibrosis

The analysis showed that the absolute prognostic criterion for the initial stage of the disease is muscle edema and the optimal impulse sequence for its visualization - diffuse-weighted image and a post-contrast T1-weighted image for revealing the disturbance of the histo-hematic barrier penetration.

Optimal Impulse Vaccination Approach for an SIR Control Model with Short-Term Immunity

Vaccines are not administered on a continuous basis, but injections are practically introduced at discrete times often separated by an important number of time units, and this differs depending on the nature of the epidemic and its associated vaccine. In addition, especially when it comes to vaccination, most optimization approaches in the literature and those that have been subject to epidemic models have focused on treating problems that led to continuous vaccination schedules but their applicability remains debatable. In search of a more realistic methodology to resolve this issue, a control modeling design, where the control can be characterized analytically and then optimized, can definitely help to find an optimal regimen of pulsed vaccinations. Therefore, we propose a susceptible-infected-removed (SIR) hybrid epidemic model with impulse vaccination control and a compartment that represents the number of vaccinated individuals supposed to not acquire sufficient immunity to become permanently recovered due to the short-term effect of vaccines. A basic reproduction number, when the control is defined as a constant parameter, is calculated. Since we also need to find the optimal values of this impulse control when it is defined as a function of time, we start by stating a general form of an impulse version of Pontryagin’s maximum principle that can be adapted to our case, and then we apply it to our model. Finally, we provide our numerical simulations that are obtained via an impulse progressive-regressive iterative scheme with fixed intervals between impulse times (theoretical example of an impulse at each week), and we conclude with a discussion of our results.