PRE- AND POST-MARKETING CONTROL OF DRUG QUALITY AT THE NATIONAL HEALTH LABORATORY, BAMAKO-MALI

Background and Objectives: In a world marked by the spread of counterfeiting and substandard drugs, often without active ingredients or falsified active ingredients, greater vigilance by pharmaceutical regulatory authorities is necessary. The National Health Laboratory (LNS), in accordance with its mission, takes samples throughout the country in order to ensure their quality control. Methods: Samples were taken in certain regions and the district of Bamako and analyzed according to the standards of the United State Pharmacopoeia (USP), British Pharmacopoeia (BP) and International Pharmacopoeia (IP)by identification and assay methods. Products that do not meet the required specifications described by these pharmacopoeias are declared non-compliant. Results: This allowed us to analyze a total of 617 samples with 11 cases of non-compliance for a rate of 2%. The causes of the non-conformities were due to the absence of an active ingredient, an under-dosage of the active ingredient and technical and regulatory defects. Conclusion: After one year of activity, our results showed that out of a total of 617 drug samples collected and analyzed, 606 were compliant with a rate of 98% against 11 cases of non-compliance or 2% (p ≤ 0,05). The causes of the non-compliance were due to the absence of an active ingredient, an under-dosage of the active ingredient and technical and regulatory defects. Peer Review History: Received: 20 November 2021; Revised: 18 December; Accepted: 31 December, Available online: 15 January 2022 Academic Editor: Dr. Asia Selman Abdullah, Pharmacy institute, University of Basrah, Iraq, [email protected] UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file: Reviewer's Comments: Average Peer review marks at initial stage: 5.5/10 Average Peer review marks at publication stage: 7.0/10 Reviewers: Dr. Govind Vyas, Compliance & Regulatory Officer Inva-Tech Pharmaceuticals LLC, New-Jersey, USA, [email protected] Dr. Muhammad Zahid Iqbal, AIMST University, Malaysia, [email protected] Dr. Bilge Ahsen KARA, Ankara Gazi Mustafa Kemal Hospital, Turkey, [email protected] Dr. Mohammad Bayan, Faculty of Pharmacy, Philadelphia University, P.O. Box: 1 Philadelphia University 19392 Jordan, [email protected] Similar Articles: ASSESSMENT OF COMMUNITY PHARMACIST AWARENESS ON ADVERSE DRUG REACTION (ADR) AND PHARMACOVIGILANCE REPORTING SYSTEM IN KHARTOUM LOCALITY, SUDAN THE EFFICIENCY OF INEFFICIENCY: MEDICINE DISTRIBUTION IN SUDAN

COVID-19 PANDEMIC AWARENESS AND ITS IMPACT ON BANGLADESHI PEOPLE: A COMMUNITY BASED SURVEY

Background: The present study has been carried out to find out the people’s perception about the COVID-19 pandemic and the effects of this pandemic on their daily lives. Methods: A Google form was used to create an online survey questionnaire distributed via personal relationships and social media. Data were collected using questionnaires consisting of socio-demographic status of participants, COVID-19 concepts and changes in the participants’ lifestyle. A total of 1088 respondents took part in the survey, and the results were evaluated using several statistical approaches. The results were presented in a variety of tables and graphs. Results: Males made up 53.3% of the participants, while females made up 46.7% who were from villages (29.87%), cities (53.77%), and semi-urban areas (16.36%). Most participants reported that they got information about the COVID-19 pandemic from social media, and they cited 'fever' as an indicator of the sickness. Although the amount of physical interactions with friends and family has not dropped much, working conditions and employment status have significantly altered. The majority of the participants claimed they have no concerns about the COVID-19. Conclusion: For up-to-date information regarding COVID-19, people in Bangladesh from all walks of life rely largely on social media. COVID-19 awareness isn't enough to inhibit the spreading of the virus from community to community. Employees' work schedules have also been drastically altered. To prevent transmission, we should all follow the safety rules strictly. Peer Review History: Received: 4 November 2021; Revised: 17 December; Accepted: 28 December, Available online: 15 January 2022 Academic Editor: Dr. Muhammad Zahid Iqbal, AIMST University, Malaysia, [email protected] UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file: Reviewer's Comments: Average Peer review marks at initial stage: 5.5/10 Average Peer review marks at publication stage: 7.0/10 Reviewers: Dr. Eyassu Mathewos, School of public health, college of health sciences and medicine, Wolaita Soddo university- P.O. Box 158, Wolaita Soddo, Ethiopia. Dr. Barkat Ali Khan, Kampala International University , Uganda, [email protected] Similar Articles: COVID-19: PHARMACOLOGICAL AND THERAPEUTIC APPROACHES COVID-19 IN MEXICO: PREPARING FOR FUTURE PANDEMICS

ACQUIRED NEONATAL SEVERE FACTOR II DEFICIENCY- TWO CASES REPORT

In present study two cases of transient acquired and isolated factor II deficiency associated with severe bleeding are reported. Two infants were involved in severe coagulopathy. The blood clot time (CT) in case 2 was excessively prolonged over 16 hours. One-stage prothrombin time (PT) was remarkable prolonged. Haemostatic markers analysis showed an isolated deficiency of factor II at 2.5% and 4.5% respectively. No inhibitory activity against factor II could be detected. We successfully treated the deficiency with vitamin K1 during 15 days. It was interesting that in the case 2 female baby the cause of vitamin K deficiency might be breast feed problem (nutrition deficiency) and/or poor absorption from bowel. Physiopathological laboratory results and therapeutic aspects of two patients were presented. Peer Review History: Received: 1 November 2021; Revised: 9 December; Accepted: 28 December, Available online: 15 January 2022 Academic Editor: Dr. Sally A. El-Zahaby, Pharos University in Alexandria, Egypt, [email protected] UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file: Reviewer's Comments: Average Peer review marks at initial stage: 6.0/10 Average Peer review marks at publication stage: 7.0/10 Reviewers: Prof. Dr. Hassan A.H. Al-Shamahy, Sana'a University, Yemen, [email protected] Dr. Ogbonna B. Onyebuchi, Nnamdi Azikiwe University, Awka, Nigeria, [email protected]

Seasonal Prediction of Omicron Pandemic

The ongoing coronavirus disease 2019 (COVID-19) pandemic has pushed the world in the face of another huge outbreak. In order to have a better understanding on the fast transmission of Omicron variant, we made seasonal predictions on the development of Omicron pandemic globally, as well as 11 key countries. The results demonstrated that the pandemic has an exponential-like growth rate at the initial stage of the outbreak, and will have small resurgences around April and June in north hemisphere countries and south hemisphere countries, respectively.

Synthesis of porous γ-Fe2O3 from scorodite synthesized using ultrasound irradiation and evaluation of its battery performance

The effect of 200 kHz ultrasound on scorodite synthesis at 70 °C and 3 h reaction conditions was investigated using sulfuric acidic solutions of various pH (3.0, 2.0, 1.5, 1.0, and 0.0). In contrast to the case of only O2 gas flow without ultrasound irradiation, oxidizing radicals generated by ultrasound irradiation promote Fe(II) oxidation in solution and precursor, allowing scorodite to synthesize with high crystallinity (>99%), which relates to low solubility, even in strong acid solution at pH 1.0. During synthesis, particle shape was changed to polyhedral or spindle type depending on the pH of 0.0 to 3.0. The spindle-shaped scorodite was probably formed by the decrease of precursor amount produced in initial stage of the synthesis. Furthermore, porous maghemite obtained by alkali treatment of scorodite showed initial discharge capacities of 146 mAh/g (polyhedron) and 167 mAh/g (spindle), indicating that its potential use as a cathode material for lithium-ion batteries.

Matrix mechanics regulates epithelial defence against cancer by tuning dynamic localization of filamin

In epithelia, normal cells recognize and extrude out newly emerged transformed cells by competition. This process is the most fundamental epithelial defence against cancer, whose occasional failure promotes oncogenesis. However, little is known about what factors determine the success or failure of this defence. Here we report that mechanical stiffening of extracellular matrix attenuates the epithelial defence against HRasV12-transformed cells. Using photoconversion labelling, protein tracking, and loss-of-function mutations, we attribute this attenuation to stiffening-induced perinuclear sequestration of a cytoskeletal protein, filamin. On soft matrix mimicking healthy epithelium, filamin exists as a dynamically single population, which moves to the normal cell-transformed cell interface to initiate the extrusion of transformed cells. However, on stiff matrix mimicking fibrotic epithelium, filamin redistributes into two dynamically distinct populations, including a new perinuclear pool that cannot move to the cell-cell interface. A matrix stiffness-dependent differential between filamin-Cdc42 and filamin-perinuclear cytoskeleton interaction controls this distinctive filamin localization and hence, determines the success or failure of epithelial defence on soft versus stiff matrix. Together, our study reveals how pathological matrix stiffening leads to a failed epithelial defence at the initial stage of oncogenesis.

Application of RFID Technology in Olusegun Oke Library, Ladoke Akintola University of Technology, Ogbomoso: Challenges and Future Prospects

Radio Frequency Identification (RFID) offers tracking capability to locate equipment, supplies and people in real time, and provides efficient and accurate access to library transactions such as book search, security, inventory, borrowing and book return. The paper studied many aspects of the RFID application such as budgeting, purchase process, advantages and limitation of RFID technology, documentation and financial implication, challenges faced in initial stage and remedies. A structured questionnaire using descriptive survey method was designed to collect data. The study employed the method of quantitative research to gather an in-depth understanding of the nature of usage of RFID system among users of Olusegun Oke Library. The findings of the study revealed that RFID is functional and useful in such areas as speedy circulation, easy book identification, security of library materials and other value added services while the major problem to implementation include technological limitations, interference concerns, prohibitive costs and lack of global standards. The study concluded that orientation programme for all users for the RFID enabled is very much important.

Research on the Use of Neural Network for the Prediction of College Students’ Mental Health

A healthy mental status of students plays an important role in getting quality of education. Hence, research on the prediction of college students’ mental health status is of great importance and considered as a hot area of research. In this specific research study, back propagation (BP) algorithm is adopted to learn verities of characteristics of different students from the historical data of the students including: psychological characteristics, basic personal characteristics, and socio-economic characteristics. In the initial stage of the modeling, data preprocessing steps are used to prepare the data to be used by the BP algorithm for building model. The rationales behind the use of BP algorithm are its capability of handling heterogeneity of data and exploring correlations among different characteristics. The proposed model enhances the capability of BP algorithm for risk prediction of psychological problem of the students and achieves higher precision of psychological problem prediction. The results obtained show that the error between the predicted and measured values is 0.88%.

Antioxidant Defense during Recovery of Resurrection Plant Haberlea rhodopensis from Drought- and Freezing-Induced Desiccation

In this study, the contribution of nonenzymatic (ascorbate, glutathione) and enzymatic antioxidants (superoxide dismutase, catalase, glutathione reductase, glutathione S-transferase) in the first hours of recovery of the resurrection plant Haberlea rhodopensis from drought- and freezing-induced desiccation was assessed. The initial stage of recovery after desiccation is critical for plants, but less investigated. To better understand the alterations in the activity of antioxidant enzymes, their isoenzyme patterns were determined. Our results showed that ascorbate content remained high during the first 9 h of rehydration of desiccated plants and declined when the leaves′ water content significantly increased. The glutathione content remained high at the first hour of rehydration and then strongly decreased. The changes in ascorbate and glutathione content during recovery from drought- and freezing-induced desiccation showed great similarity. At the beginning of rehydration (1–5 h), the activities of antioxidant enzymes were significantly increased or remained as in dry plants. During 7–24 h of rehydration, certain differences in the enzymatic responses between the two plant groups were registered. The maintenance of a high antioxidant activity and upregulation of individual enzyme isoforms indicated their essential role in protecting plants from oxidative damage during the onset of recovery.

Performance Evaluation of Solar-Blind Gas-Filled Sensors to Detect Electrical Discharges for Low-Pressure Aircraft Applications

Unpressurized aircraft circuits facilitate the initiation of electrical discharges in wiring systems, with consequent damage to related insulation materials and safety hazards, that can and have already caused severe incidents and accidents. Specific sensors and solutions must be developed to detect these types of faults at a very incipient stage, before further damage occurs. Electrical discharges in air generate the corona effect, which is characterized by emissions of bluish light, which are found in the ultraviolet (UV) and visible spectra. However, due to sunlight interference, the corona effect is very difficult to detect at the very initial stage, so the use of solar-blind sensors can be a possible solution. This work analyzes the feasibility of using inexpensive non-invasive solar-blind sensors in a range of pressures compatible with aircraft environments to detect the electrical discharges at a very incipient stage. Their behavior and sensitivity compared with other alternatives, i.e., an antenna sensor and a CMOS imaging sensor, is also assessed. Experimental results presented in this paper show that the analyzed solar-blind sensors can be applied for the on-line detection of electrical discharges in unpressurized aircraft environments at the very initial stage, thus facilitating and enabling the application of predictive maintenance strategies. They also offer the possibility to be combined with existing electrical protections to expand their capabilities and improve their sensitivity to detect very early discharges, thus allowing the timely identification of their occurrence.