The effect of 5alpha-dihydrotestosterone (DHT) on the level of human prostatic acid phosphatase (hPAP) mRNA was studied using tissue slices from various benign prostatic hyperplastic glands. The absence of DHT in the incubation medium led to a gradual, significant decrease of the hPAP mRNA level. Addition of the hormone induced hPAP mRNA in a time- and dose-dependent manner. The maximal 2-4-fold induction by 10(-9) M DHT was observed after 3-5 h of incubation, and then the hPAP mRNA level was 6-20-fold higher than that in a parallel sample incubated without DHT. The results suggest that DHT is necessary to sustain the expression of hPAP in hyperplastic prostates.
Quite recently two dysplastic lesions have been found in prostatic tissue: atypical hyperplasia (AH), found in the periurethral zone, and prostatic intraepithelial neoplasia (PIN), present in the peripheral zone of the prostate. These lesions are likely to be considered as preneoplastic lesions. Theoretically they could be interpreted as the link between normal prostatic tissue and the cancer. It has also been suggested that BPH possibly contributes to the carcinogenetic process due to the demonstrated modifications occuring in the hyperplastic gland.
A case of benign paraganglioma of the prostatic urethra, incidentally discovered in a hyperplastic gland, is reported. Presurgical mild systemic hypertension, which suggested the paraganglioma secreting activity, became normal in the postoperative follow-up.
Highly concentrated calcitriol and its analogues induce apoptosis of parathyroid cells and regression of the hyperplastic gland--study in rats